Publications by authors named "Dmitry B Veprintsev"

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Water molecules in the cannabinoid receptor 2 binding site crucially impact the discovery of novel ligands.
Magdalena M Scharf, Morgan Scott-Dennis, Leire Borrega-Roman, Franziska N Z Giese, Darya Plevako, Dmitry B Veprintsev

Eur J Med Chem· December 2025

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Biased Signaling and Its Role in the Genesis of Short- and Long-Acting β-Adrenoceptor Agonists.
Ngan T N Phan, Leire Borrega-Roman, Bradley L Hoare, Clare R Harwood, Natalie Geary, Dmitry B Veprintsev

Biochemistry· August 2025

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Multiple intramolecular triggers converge to preferential G protein coupling in the CBR.
Adrian Morales-Pastor, Tamara Miljuš, Miguel Dieguez-Eceolaza, Tomasz Maciej Stępniewski, Vicente Ledesma-Martin, Dmitry B Veprintsev

Nat Commun· June 2025

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Profiling Allosteric Modulators of CBR with an Allosteric Fluoroprobe.
Miroslav Kosar, Themiya Perera, Rudolf L Z Ganzoni, Roman C Sarott, Leire Borrega-Roman, Dmitry B Veprintsev

Angew Chem Int Ed Engl· May 2025

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A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay.
Leire Borrega-Roman, Bradley L Hoare, Miroslav Kosar, Roman C Sarott, Kacper J Patej, Dmitry B Veprintsev

Front Pharmacol· April 2025

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Agonist efficacy at the βAR is driven by the faster association rate of the G protein.
Clare R Harwood, David A Sykes, Theo Redfern-Nichols, Owen Underwood, Colin Nicholson, Dmitry B Veprintsev

Front Pharmacol· March 2025

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Structural basis of THC analog activity at the Cannabinoid 1 receptor.
Thor S Thorsen, Yashraj Kulkarni, David A Sykes, Andreas Bøggild, Taner Drace, Dmitry B Veprintsev

Nat Commun· January 2025

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A Modified Cell-Penetrating Peptide Enhances Insulin and Oxytocin Delivery across an RPMI 2650 Nasal Epithelial Cell Barrier In Vitro.
Sara Wong, Alexander D Brown, Abigail B Abrahams, An Nisaa Nurzak, Hoda M Eltaher, Dmitry B Veprintsev

Pharmaceutics· September 2024

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Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f.
Anastasiia Gusach, Yang Lee, Armin Nikpour Khoshgrudi, Elizaveta Mukhaleva, Ning Ma, Dmitry B Veprintsev

Nat Commun· August 2024

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Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.
Johannes Aebi, Kenneth Atz, Simon M Ametamey, Jörg Benz, Julie Blaising, Dmitry B Veprintsev

Chimia (Aarau)· August 2024

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Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CBR).
Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Dmitry B Veprintsev

J Med Chem· July 2024

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Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists.
Miroslav Kosar, Roman C Sarott, David A Sykes, Alexander E G Viray, Rosa Maria Vitale, Dmitry B Veprintsev

ACS Cent Sci· May 2024

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Mechano-sensitivity of β2-adrenoceptors enhances constitutive activation of cAMP generation that is inhibited by inverse agonists.
Sean A Cullum, Simon Platt, Natasha Dale, Oliver C Isaac, Edward S Wragg, Dmitry B Veprintsev

Commun Biol· April 2024

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ThermoBRET: A Ligand-Engagement Nanoscale Thermostability Assay Applied to GPCRs.
Bradley L Hoare, David N Tippett, Amandeep Kaur, Sean A Cullum, Tamara Miljuš, Dmitry B Veprintsev

Chembiochem· January 2024

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Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors.
Morgan Scott-Dennis, Fikri A Rafani, Yicheng Yi, Themiya Perera, Clare R Harwood, Dmitry B Veprintsev

Front Pharmacol· August 2023

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Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells.
Miroslav Kosar, David A Sykes, Alexander E G Viray, Rosa Maria Vitale, Roman C Sarott, Dmitry B Veprintsev

J Am Chem Soc· July 2023

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Kinetic analysis of endogenous β -adrenoceptor-mediated cAMP GloSensor™ responses in HEK293 cells.
Sean A Cullum, Dmitry B Veprintsev, Stephen J Hill

Br J Pharmacol· May 2023

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Combined docking and machine learning identify key molecular determinants of ligand pharmacological activity on β2 adrenoceptor.
Mireia Jiménez-Rosés, Bradley Angus Morgan, Maria Jimenez Sigstad, Thuy Duong Zoe Tran, Rohini Srivastava, Dmitry B Veprintsev

Pharmacol Res Perspect· October 2022

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Michaelis-Menten Quantification of Ligand Signaling Bias Applied to the Promiscuous Vasopressin V2 Receptor.
Franziska Marie Heydenreich, Bianca Plouffe, Aurélien Rizk, Dalibor Milić, Joris Zhou, Dmitry B Veprintsev

Mol Pharmacol· September 2022

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Exploring the kinetic selectivity of drugs targeting the β -adrenoceptor.
David A Sykes, Mireia Jiménez-Rosés, John Reilly, Robin A Fairhurst, Steven J Charlton, Dmitry B Veprintsev

Pharmacol Res Perspect· August 2022

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Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe.
Thais Gazzi, Benjamin Brennecke, Kenneth Atz, Claudia Korn, David Sykes, Dmitry B Veprintsev

Chem Sci· May 2022

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GPCR activation mechanisms across classes and macro/microscales.
Alexander S Hauser, Albert J Kooistra, Christian Munk, Franziska M Heydenreich, Dmitry B Veprintsev

Nat Struct Mol Biol· November 2021

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GPCR Activation States Induced by Nanobodies and Mini-G Proteins Compared by NMR Spectroscopy.
Philip Rößler, Daniel Mayer, Ching-Ju Tsai, Dmitry B Veprintsev, Gebhard F X Schertler

Molecules· December 2020

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Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells.
Leigh A Stoddart, Nicholas D Kindon, Omolade Otun, Clare R Harwood, Foteini Patera, Dmitry B Veprintsev

Commun Biol· November 2020

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Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells.
Roman C Sarott, Matthias V Westphal, Patrick Pfaff, Claudia Korn, David A Sykes, Dmitry B Veprintsev

J Am Chem Soc· October 2020

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