Publications by authors named "Dmitry Prokopenko"

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Analyzing associations and higher-order effects in multi-omics data with double machine learning.
Julian Hecker, Dmitry Prokopenko, Georg Hahn, Sanghun Lee, Sharon M Lutz

bioRxiv· December 2025

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Sex differences in the impact of genetic and clinical risk factors for Alzheimer's disease in midlife.
Kyoko Konishi, Dylan S Spets, Paris Fisher, Sarah Aroner, Sarah M Sant, Dmitry Prokopenko

J Alzheimers Dis· October 2025

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Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease.
Isabel Castanho, Pourya Naderi Yeganeh, Carles A Boix, Sarah L Morgan, Hansruedi Mathys, Dmitry Prokopenko

Mol Neurodegener· October 2025

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FBAT DAP-G: fine-mapping of genetic associations in family-based studies using the Deterministic Approximation of Posteriors algorithm.
Julian Hecker, Dmitry Prokopenko, Sanghun Lee, Sharon M Lutz, Rudolph E Tanzi

Bioinform Adv· October 2025

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The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease by impairing microglial function.
Dominika J Pilat, Hoang Le, Dmitry Prokopenko, Chih-Chung Jerry Lin, William A Eimer

Neuron· October 2025

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Matching Heterogeneous Cohorts by Projected Principal Components Reveals Two Novel Alzheimer's Disease-Associated Genes in the Hispanic Population.
Julian Daniel Sunday Willett, Mohamad Waqas, Serhiy Naumenko, Kristina Mullin, Julian Hecker, Dmitry Prokopenko

medRxiv· September 2025

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Uncovering Ethnicity-Specific Recessive Loci for Alzheimer's Disease in 89 Dominican Families Using Family-Based WGS Analysis.
Sanghun Lee, Julian Hecker, Badri N Vardarajan, Rachel S Kelly, Nicole Prince, Dmitry Prokopenko

Genet Epidemiol· July 2025

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A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer's disease.
Maria Celeste Gauron, Dmitry Prokopenko, Sanghun Lee, Sarah A Wolfe, Julian Hecker

Sci Signal· July 2025

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Context-dependent regulatory variants in Alzheimer's disease.
Ziheng Chen, Yaxuan Liu, Ashley R Brown, Heather H Sestili, Easwaran Ramamurthy, Dmitry Prokopenko

bioRxiv· July 2025

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Associations of APOE variants with sphingomyelin and cholesterol metabolites across the life-course in diverse populations.
Sanghun Lee, Rachel S Kelly, Yulu Chen, Mohammad Waqas, Kevin M Mendez, Dmitry Prokopenko

Metabolomics· May 2025

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Annexin A6 membrane repair protein protects against amyloid-induced dystrophic neurites and tau phosphorylation in Alzheimer's disease model mice.
Katherine R Sadleir, Karen P Gomez, Abigail E Edwards, Armana J Patel, Makenna L Ley, Dmitry Prokopenko

Acta Neuropathol· May 2025

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Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer's disease using a recessive mode of inheritance.
Maria Celeste Gauron, Dmitry Prokopenko, Sanghun Lee, Sarah A Wolfe, Julian Hecker

medRxiv· May 2025

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On the analysis of metabolite quantitative trait loci: Impact of different data transformations and study designs.
Sanghun Lee, Rachel S Kelly, Kevin M Mendez, Dmitry Prokopenko, Georg Hahn

Sci Adv· April 2025

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Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice.
Xiaoye Ma, Dmitry Prokopenko, Ni Wang, Tomonori Aikawa, Younjung Choi

Neurobiol Dis· March 2025

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Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.
Julian Daniel Sunday Willett, Mohammad Waqas, Younjung Choi, Tiffany Ngai, Kristina Mullin, Dmitry Prokopenko

Alzheimers Dement· February 2025

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Polygenic hazard score models for the prediction of Alzheimer's free survival using the lasso for Cox's proportional hazards model.
Georg Hahn, Dmitry Prokopenko, Julian Hecker, Sharon M Lutz, Kristina Mullin

Genet Epidemiol· January 2025

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Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer's disease.
Isabel Castanho, Pourya Naderi Yeganeh, Carles A Boix, Sarah L Morgan, Hansruedi Mathys, Dmitry Prokopenko

bioRxiv· January 2025

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Assessing polyomic risk to predict Alzheimer's disease using a machine learning model.
Tiffany Ngai, Julian Willett, Mohammad Waqas, Lucas H Fishbein, Younjung Choi, Dmitry Prokopenko

Alzheimers Dement· December 2024

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Identification of 16 novel Alzheimer's disease susceptibility loci using multi-ancestry meta-analyses of clinical Alzheimer's disease and AD-by-proxy cases from four whole genome sequencing datasets.
Julian Daniel Sunday Willett, Mohammad Waqas, Younjung Choi, Tiffany Ngai, Kristina Mullin, Dmitry Prokopenko

medRxiv· September 2024

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Single-cell multiregion dissection of Alzheimer's disease.
Hansruedi Mathys, Carles A Boix, Leyla Anne Akay, Ziting Xia, Jose Davila-Velderrain, Dmitry Prokopenko

Nature· August 2024

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Association of with Coronary Artery Calcium Differs by Sex and Cigarette Smoking.
Kirsten Voorhies, Kendra Young, Fang-Chi Hsu, Nicholette D Palmer, Merry-Lynn N McDonald, Dmitry Prokopenko

J Cardiovasc Dev Dis· June 2024

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On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries.
Sanghun Lee, Julian Hecker, Georg Hahn, Kristina Mullin, , Dmitry Prokopenko

Alzheimers Dement· May 2024

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Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
Nick Shrine, Anna L Guyatt, A Mesut Erzurumluoglu, Victoria E Jackson, Brian D Hobbs, Dmitry Prokopenko

Nat Genet· May 2024

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Prediction of disease-free survival for precision medicine using cooperative learning on multi-omic data.
Georg Hahn, Dmitry Prokopenko, Julian Hecker, Sharon M Lutz, Kristina Mullin

Brief Bioinform· May 2024

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Examining the Effect of Genes on Depression as Mediated by Smoking and Modified by Sex.
Kirsten Voorhies, Julian Hecker, Sanghun Lee, Georg Hahn, Dmitry Prokopenko

Genes (Basel)· April 2024

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