Publications by authors named "Dominik Jacob"

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extrapolation of intrinsic clearance based on data from human hepatocyte spheroids - a case study with the low-clearance drug xevinapant.
Dominik Jacob, Ulrike Gradhand, Christine K Maurer, Holger Scheible, Christian Stelz

Xenobiotica· November 2025

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Evaluation of small interfering RNA-dependent knockdowns of drug-metabolizing enzymes in multiwell array culture of primary human hepatocyte spheroids for estimation of fraction metabolized.
Lena Brücker, Dominik Jacob, Lena C Preiss, Yi Zhong, Felix Geist

Drug Metab Dispos· April 2025

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Binding and/or hydrolysis of purine-based nucleotides is not required for IM30 ring formation.
Carmen Siebenaller, Lukas Schlösser, Benedikt Junglas, Martina Schmidt-Dengler, Dominik Jacob

FEBS Lett· July 2021

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Hakai is required for stabilization of core components of the mA mRNA methylation machinery.
Praveen Bawankar, Tina Lence, Chiara Paolantoni, Irmgard U Haussmann, Migle Kazlauskiene, Dominik Jacob

Nat Commun· June 2021

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Bacterial tRNA 2'-O-methylation is dynamically regulated under stress conditions and modulates innate immune response.
Adeline Galvanin, Lea-Marie Vogt, Antonia Grober, Isabel Freund, Lilia Ayadi, Dominik Jacob

Nucleic Acids Res· December 2020

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Absolute Quantification of Noncoding RNA by Microscale Thermophoresis.
Dominik Jacob, Kathrin Thüring, Aurellia Galliot, Virginie Marchand, Adeline Galvanin

Angew Chem Int Ed Engl· July 2019

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Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the mA machinery component Wtap/Fl(2)d.
Philip Knuckles, Tina Lence, Irmgard U Haussmann, Dominik Jacob, Nastasja Kreim

Genes Dev· March 2018

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Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs.
Carine Legrand, Francesca Tuorto, Mark Hartmann, Reinhard Liebers, Dominik Jacob

Genome Res· September 2017

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Sleep disturbances in myotonic dystrophy type 2.
Paul Shepard, Erek M Lam, Erik K St Louis, Jacob Dominik

Eur Neurol· July 2013

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Chronic cough as the presenting symptom of hydrocephalus.
Selmin Karatayli-Ozgursoy, Jacob Dominik, Benjamin Eidelman, Juan C Guarderas

South Med J· June 2010

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Leflunomide-associated progressive multifocal leukoencephalopathy.
Megan Rahmlow, Elizabeth A Shuster, Jacob Dominik, H Gordon Deen, Dennis W Dickson

Arch Neurol· November 2008

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