Publications by authors named "Donald E Slaughter"

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Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
Christopher D Cox, Paul J Coleman, Michael J Breslin, David B Whitman, Robert M Garbaccio, Donald E Slaughter

J Med Chem· July 2008

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Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.
Robert M Garbaccio, Edward S Tasber, Lou Anne Neilson, Paul J Coleman, Mark E Fraley, Donald E Slaughter

Bioorg Med Chem Lett· October 2007

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Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.
Christopher D Cox, Maricel Torrent, Michael J Breslin, Brenda J Mariano, David B Whitman, Donald E Slaughter

Bioorg Med Chem Lett· June 2006

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Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.
Robert M Garbaccio, Mark E Fraley, Edward S Tasber, Christy M Olson, William F Hoffman, Donald E Slaughter

Bioorg Med Chem Lett· April 2006

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Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.
Ping Lu, Michael L Schrag, Donald E Slaughter, Conrad E Raab, Magang Shou

Drug Metab Dispos· November 2003

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Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I(Ks)-blocking class III antiarrhythmic agents.
John W Butcher, Nigel J Liverton, David A Claremon, Roger M Freidinger, Nancy K Jurkiewicz, Donald E Slaughter

Bioorg Med Chem Lett· March 2003

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