Publications by authors named "Donald Lo"

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The eyes of the beholder: Perceived barriers to successful drug repurposing.
Zsuzsanna Ida Petykó, Dalma Hosszú, Marcell Csanádi, Kristóf Gyöngyösi, George Dennis Obeng, Donald C Lo

Br J Pharmacol· January 2026

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Computational drug repurposing: approaches, evaluation of in silico resources and case studies.
Ziaurrehman Tanoli, Adrià Fernández-Torras, Umut Onur Özcan, Aleksandr Kushnir, Kristen Michelle Nader, Brinton Seashore-Ludlow, Andrea Polo, Alfredo Budillon, Donald C Lo

Nat Rev Drug Discov· July 2025

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Adeno-Associated Virus Gene Therapy Development: Early Planning and Regulatory Considerations to Advance the Platform Vector Gene Therapy Program.
Richa Madan Lomash, Jean Dehdashti, Oleg A Shchelochkov, Randy J Chandler, Lina Li, Jennifer L Sloan, Donald C Lo

Hum Gene Ther· March 2025

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Reliable business case for repurposing of existing medicines requires key changes in government policies.
Samuel J de Visser, Sibren van den Berg, Arend Mosterd, Donald C Lo

Drug Discov Today· September 2024

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Editorial: Impacts of public-private collaborative research on Alzheimer's disease: the case of the innovative medicines initiative.
Elisabetta Vaudano, Jean Georges, Martin Hofmann-Apitius, Donald Lo

Front Neurol· November 2023

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An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics.
Shayan G Borhani, Max Z Levine, Lauren H Krumpe, Jennifer Wilson, Curtis J Henrich, Donald C Lo

N Biotechnol· September 2023

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An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics.
Shayan G Borhani, Max Z Levine, Lauren H Krumpe, Jennifer Wilson, Curtis J Henrich, Donald Lo

bioRxiv· December 2022

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High-Throughput Platform for Novel Reaction Discovery.
Xiao Lu, Zhiji Luo, Ruili Huang, Donald C Lo, Wenwei Huang

Chemistry· September 2022

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Preclinical target validation for non-addictive therapeutics development for pain.
Richard Hargreaves, Karen Akinsanya, Seena K Ajit, Neel T Dhruv, Jamie Driscoll, Donald C Lo

Expert Opin Ther Targets· September 2022

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A call to action for translational sciences in COVID-19 and future pandemics.
Kanny K Wan, Danielle Davis, Taylor N Lee, Stephanie L Ford-Scheimer, Antonio L Andreu, Florence Bietrix, Carlos M Morel, Donald C Lo, Christine M Cutillo

Nat Rev Drug Discov· March 2022

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Drug combination therapy for emerging viral diseases.
Zeenat A Shyr, Yu-Shan Cheng, Donald C Lo, Wei Zheng

Drug Discov Today· October 2021

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Viral Proteases as Targets for Coronavirus Disease 2019 Drug Development.
Wei Zhu, Zeenat Shyr, Donald C Lo, Wei Zheng

J Pharmacol Exp Ther· August 2021

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The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules.
Kirill Gorshkov, Catherine Z Chen, Robert Bostwick, Lynn Rasmussen, Bruce Nguyen Tran, Juan Carlos de la Torre, Donald C Lo

ACS Infect Dis· June 2021

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Biological activity-based modeling identifies antiviral leads against SARS-CoV-2.
Ruili Huang, Miao Xu, Hu Zhu, Catherine Z Chen, Wei Zhu, Donald Lo

Nat Biotechnol· June 2021

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Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.
Khalida Shamim, Miao Xu, Xin Hu, Emily M Lee, Xiao Lu, Donald C Lo

Bioorg Med Chem Lett· May 2021

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Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.
Catherine Z Chen, Paul Shinn, Zina Itkin, Richard T Eastman, Robert Bostwick, Donald C Lo

Front Pharmacol· January 2021

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RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery.
Wei Zhu, Catherine Z Chen, Kirill Gorshkov, Miao Xu, Donald C Lo

SLAS Discov· December 2020

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The Platform Vector Gene Therapies Project: Increasing the Efficiency of Adeno-Associated Virus Gene Therapy Clinical Trial Startup.
Philip J Brooks, Elizabeth A Ottinger, Deanna Portero, Richa Madan Lomash, Asaf Alimardanov, Donald C Lo

Hum Gene Ther· October 2020

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Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.
Catherine Z Chen, Paul Shinn, Zina Itkin, Richard T Eastman, Robert Bostwick, Donald C Lo

bioRxiv· August 2020

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Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2.
Ruili Huang, Miao Xu, Hu Zhu, Catherine Z Chen, Emily M Lee, Donald Lo

bioRxiv· July 2020

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An OpenData portal to share COVID-19 drug repurposing data in real time.
Kyle R Brimacombe, Tongan Zhao, Richard T Eastman, Xin Hu, Ke Wang, Bolormaa Baljinnyam, Donald C Lo

bioRxiv· June 2020

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The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators.
Kirill Gorshkov, Catherine Z Chen, Robert Bostwick, Lynn Rasmussen, Miao Xu, Donald C Lo

bioRxiv· May 2020

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MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling.
Divya Venkatesh, Nicholas A O'Brien, Fereshteh Zandkarimi, David R Tong, Michael E Stokes, Donald C Lo, Angelo D'Alessandro

Genes Dev· April 2020

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Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery.
Ling F Ye, Eduard Reznik, Joshua M Korn, Fallon Lin, Guizhi Yang, Alice Loo, Donald C Lo

Oncotarget· January 2020

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Tumoricidal stem cell therapy enables killing in novel hybrid models of heterogeneous glioblastoma.
Andrew B Satterlee, Denise E Dunn, Donald C Lo, Simon Khagi, Shawn Hingtgen

Neuro Oncol· December 2019

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