Publications by authors named "Dorian M Cheff"

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Arsenic exposure and increased -reactive protein are independently associated with lower erythrocyte glutathione peroxidase activity in Bangladeshi children.
Dorian M Cheff, Helena Skröder, Evana Akhtar, Qing Cheng, Matthew D Hall

Redox Biochem Chem· December 2023

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Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4.
Dorian M Cheff, Qing Cheng, Hui Guo, Jameson Travers, Carleen Klumpp-Thomas

Redox Biol· July 2023

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The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1.
Dorian M Cheff, Chuying Huang, Karoline C Scholzen, Radosveta Gencheva, Michael H Ronzetti

Redox Biol· June 2023

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Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities.
Dorian M Cheff, Alysson R Muotri, Brent R Stockwell, Edward E Schmidt, Qitao Ran

Orphanet J Rare Dis· October 2021

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Discovery and Optimization of 2-1λ-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
Jason M Rohde, Surendra Karavadhi, Rajan Pragani, Li Liu, Yuhong Fang, Dorian M Cheff

J Med Chem· April 2021

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Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
Ganesha Rai, Daniel J Urban, Bryan T Mott, Xin Hu, Shyh-Ming Yang, Dorian M Cheff

J Med Chem· October 2020

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Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences.
Jacob S Roth, Tobie D Lee, Dorian M Cheff, Maya L Gosztyla, Rosita R Asawa

SLAS Discov· June 2020

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Predictive models for estimating cytotoxicity on the basis of chemical structures.
Hongmao Sun, Yuhong Wang, Dorian M Cheff, Matthew D Hall, Min Shen

Bioorg Med Chem· May 2020

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Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
Olivia W Lee, Shelley Austin, Madison Gamma, Dorian M Cheff, Tobie D Lee

SLAS Discov· January 2020

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Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling.
Amanda Balboni Iniguez, Gabriela Alexe, Emily Jue Wang, Giovanni Roti, Sarvagna Patel, Dorian M Cheff

Cancer Cell· December 2018

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Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
Sara E Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R Brimacombe, Mark J Henderson, Caitlin Lynch, Dorian M Cheff

ACS Cent Sci· December 2018

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Correction to A Drug of Such Damned Nature. Challenges and Opportunities in Translational Platinum Drug Research.
Dorian M Cheff, Matthew D Hall

J Med Chem· October 2018

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High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.
Nathan P Coussens, Stephen C Kales, Mark J Henderson, Olivia W Lee, Kurumi Y Horiuchi, Dorian M Cheff

J Biol Chem· August 2018

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Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
Jason M Rohde, Kyle R Brimacombe, Li Liu, Michael E Pacold, Adam Yasgar, Dorian M Cheff

Bioorg Med Chem· May 2018

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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Ganesha Rai, Kyle R Brimacombe, Bryan T Mott, Daniel J Urban, Xin Hu, Dorian M Cheff

J Med Chem· November 2017

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Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.
Daniel J Urban, Natalia J Martinez, Mindy I Davis, Kyle R Brimacombe, Dorian M Cheff

Sci Rep· October 2017

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A Drug of Such Damned Nature.1 Challenges and Opportunities in Translational Platinum Drug Research.
Dorian M Cheff, Matthew D Hall

J Med Chem· June 2017

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