Publications by authors named "Surendra Karavadhi"

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Discovery of novel and selective GPR17 antagonists as pharmacological tools for developing new therapeutic strategies in diabetes and obesity.
Hu Zhu, Jason M Conley, Surendra Karavadhi, Justin E LaVigne, Val J Watts

Eur J Med Chem· October 2025

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An electrophilic fragment screening for the development of small molecules targeting caspase-2.
Matthew E Cuellar, Mu Yang, Surendra Karavadhi, Ya-Qin Zhang, Hu Zhu

Eur J Med Chem· November 2023

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Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen.
Victor Clausse, Yuhong Fang, Dingyin Tao, Harichandra D Tagad, Hongmao Sun, Surendra Karavadhi

ACS Pharmacol Transl Sci· October 2022

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Virtual Screening for the Discovery of Microbiome β-Glucuronidase Inhibitors to Alleviate Cancer Drug Toxicity.
Anup P Challa, Xin Hu, Ya-Qin Zhang, Jeffrey Hymes, Bret D Wallace, Surendra Karavadhi

J Chem Inf Model· April 2022

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Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors.
Li Liu, Manshu Tang, Rajan Pragani, Frank G Whitby, Ya-Qin Zhang, Surendra Karavadhi

J Med Chem· September 2021

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Discovery and Optimization of 2-1λ-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
Jason M Rohde, Surendra Karavadhi, Rajan Pragani, Li Liu, Yuhong Fang

J Med Chem· April 2021

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Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
Sara E Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R Brimacombe, Mark J Henderson, Caitlin Lynch, Surendra Karavadhi

ACS Cent Sci· December 2018

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Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.
Daniel J Urban, Natalia J Martinez, Mindy I Davis, Kyle R Brimacombe, Dorian M Cheff, Surendra Karavadhi

Sci Rep· October 2017

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Reversal of the importance of steric and electronic effects in the base-promoted α-silylation of sulfides.
Karavadhi Surendra, Rajender Vemula, Yifeng Han, E J Corey

Org Lett· April 2015

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Diiodoindium(III) cation, InI₂⁺, a potent yneophile. Generation and application to cationic cyclization by selective π-activation of C≡C.
Karavadhi Surendra, E J Corey

J Am Chem Soc· August 2014

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Useful catalytic enantioselective cationic double annulation reactions initiated at an internal π-bond: method and applications.
Karavadhi Surendra, Goreti Rajendar, E J Corey

J Am Chem Soc· January 2014

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Highly enantioselective proton-initiated polycyclization of polyenes.
Karavadhi Surendra, E J Corey

J Am Chem Soc· July 2012

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Selective formation of six-membered oxa- and carbocycles by the In(III)-activated ring closure of acetylenic substrates.
Wen-Wei Qiu, Karavadhi Surendra, Liang Yin, E J Corey

Org Lett· November 2011

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A powerful new construction of complex chiral polycycles by an indium(III)-catalyzed cationic cascade.
Karavadhi Surendra, Wenwei Qiu, E J Corey

J Am Chem Soc· June 2011

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A short enantioselective total synthesis of the fundamental pentacyclic triterpene lupeol.
Karavadhi Surendra, E J Corey

J Am Chem Soc· October 2009

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Rapid and enantioselective synthetic approaches to germanicol and other pentacyclic triterpenes.
Karavadhi Surendra, E J Corey

J Am Chem Soc· July 2008

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