Publications by authors named "Doug Speed"

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Predicted protein 3D structures provide essential insights into the genetic architecture underlying phenotypic diversity in maize.
Shuai Wang, Merritt Khaipho-Burch, Lynn C Johnson, Zachary R Miller, Peter J Bradbury, Doug Speed

Genome Res· December 2025

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Recent Statistical Innovations in Human Genetics.
David J Balding, Doug Speed

Ann Hum Genet· September 2025

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LDAK-KVIK performs fast and powerful mixed-model association analysis of quantitative and binary phenotypes.
Jasper P Hof, Doug Speed

Nat Genet· September 2025

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Association Between Polygenic Risk Scores and Treatment Response to Antidepressants, Benzodiazepines, and Antihistamines in Anxiety and Depression.
Amelie Markant, Fara Tabrizi, Hampus Grönvall, Doug Speed, Fredrik Åhs

Biol Psychiatry Glob Open Sci· May 2025

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Genome-wide association meta-analyses of drug-resistant epilepsy.
Costin Leu, Andreja Avbersek, Remi Stevelink, Helena Martins Custodio, Siwei Chen, Doug Speed

EBioMedicine· May 2025

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Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.
Albert Henry, Xiaodong Mo, Chris Finan, Mark D Chaffin, Doug Speed

Nat Genet· April 2025

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Heritability and polygenic load for comorbid anxiety and depression.
Fara Tabrizi, Jörgen Rosén, Hampus Grönvall, Victor Rahimzadeh William-Olsson, Erik Arner, Doug Speed

Transl Psychiatry· March 2025

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Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy.
Sean L Zheng, Albert Henry, Douglas Cannie, Michael Lee, David Miller, Doug Speed

Nat Genet· December 2024

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The heritability of fitness in a wild annual plant population with hierarchical size structure.
Daniel J Schoen, Doug Speed

Evolution· October 2024

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Using the Bayesian variational spike and slab model in a genome-wide association study for finding associated loci with bipolar disorder.
Maryam Kazemi Naeini, Mahdi Akbarzadeh, Iraj Kazemi, Doug Speed, Sayed Mohsen Hosseini

Ann Hum Genet· May 2024

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Estimating disease heritability from complex pedigrees allowing for ascertainment and covariates.
Doug Speed, David M Evans

Am J Hum Genet· April 2024

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Using polygenic risk scores to investigate the evolution of smoking and mental health outcomes in UK biobank participants.
Lloyd Balbuena, Evyn Peters, Doug Speed

Acta Psychiatr Scand· November 2023

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Participation bias in the UK Biobank distorts genetic associations and downstream analyses.
Tabea Schoeler, Doug Speed, Eleonora Porcu, Nicola Pirastu, Jean-Baptiste Pingault

Nat Hum Behav· July 2023

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Genetic liability to bipolar disorder and body mass index: A bidirectional two-sample Mendelian randomization study.
Lars Meinertz Byg, Maria Speed, Doug Speed, Søren Dinesen Østergaard

Bipolar Disord· February 2023

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LDAK-GBAT: Fast and powerful gene-based association testing using summary statistics.
Takiy-Eddine Berrandou, David Balding, Doug Speed

Am J Hum Genet· January 2023

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Heritability of insidious uveitis in Appaloosa horses.
Nicole B Kingsley, Lynne Sandmeyer, Elaine M Norton, Doug Speed, Ann Dwyer

Anim Genet· December 2022

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Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis.
Cooper Alastair Grace, Kátia Silene Sousa Carvalho, Mayara Ingrid Sousa Lima, Vladimir Costa Silva, João Luís Reis-Cunha, Doug Speed

mBio· December 2022

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Graph pangenome captures missing heritability and empowers tomato breeding.
Yao Zhou, Zhiyang Zhang, Zhigui Bao, Hongbo Li, Yaqing Lyu, Doug Speed

Nature· June 2022

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The Effects of Common Genetic Variation in 96 Genes Involved in Thyroid Hormone Regulation on TSH and FT4 Concentrations.
Rosalie B T M Sterenborg, Tessel E Galesloot, Alexander Teumer, Romana T Netea-Maier, Doug Speed

J Clin Endocrinol Metab· May 2022

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SNP-based heritability and selection analyses: Improved models and new results.
Doug Speed, Anubhav Kaphle, David J Balding

Bioessays· May 2022

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Genome-wide association, prediction and heritability in bacteria with application to .
Sudaraka Mallawaarachchi, Gerry Tonkin-Hill, Nicholas J Croucher, Paul Turner, Doug Speed

NAR Genom Bioinform· March 2022

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Bipolar disorder and cannabis use: A bidirectional two-sample Mendelian randomization study.
Oskar Hougaard Jefsen, Maria Speed, Doug Speed, Søren Dinesen Østergaard

Addict Biol· November 2021

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Signatures of TSPAN8 variants associated with human metabolic regulation and diseases.
Tisham De, Angela Goncalves, Doug Speed, Philippe Froguel,

iScience· August 2021

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Improved genetic prediction of complex traits from individual-level data or summary statistics.
Qianqian Zhang, Florian Privé, Bjarni Vilhjálmsson, Doug Speed

Nat Commun· July 2021

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