Publications by authors named "Douglas Hansen"

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High-throughput reprogramming of an NRPS condensation domain.
Ines B Folger, Natália F Frota, Angelos Pistofidis, David L Niquille, Douglas A Hansen

Nat Chem Biol· June 2024

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Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases.
Aaron A Koch, Jennifer J Schmidt, Andrew N Lowell, Douglas A Hansen, Katherine M Coburn

Angew Chem Int Ed Engl· August 2020

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Evolution of a highly active and enantiospecific metalloenzyme from short peptides.
Sabine Studer, Douglas A Hansen, Zbigniew L Pianowski, Peer R E Mittl, Aaron Debon

Science· December 2018

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Nonribosomal biosynthesis of backbone-modified peptides.
David L Niquille, Douglas A Hansen, Takahiro Mori, David Fercher, Hajo Kries

Nat Chem· March 2018

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A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst.
Aaron A Koch, Douglas A Hansen, Vikram V Shende, Lawrence R Furan, K N Houk

J Am Chem Soc· September 2017

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Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides.
Douglas A Hansen, Aaron A Koch, David H Sherman

J Am Chem Soc· September 2017

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Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Mashal M Almutairi, Maxim S Svetlov, Douglas A Hansen, Nelli F Khabibullina, Dorota Klepacki

Nucleic Acids Res· September 2017

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Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.
Irina Koryakina, Christian Kasey, John B McArthur, Andrew N Lowell, Joseph A Chemler, Douglas A Hansen

ACS Chem Biol· January 2017

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Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides.
Mashal M Almutairi, Sung Ryeol Park, Simon Rose, Douglas A Hansen, Nora Vázquez-Laslop

Proc Natl Acad Sci U S A· October 2015

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Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination.
Joseph A Chemler, Ashootosh Tripathi, Douglas A Hansen, Mark O'Neil-Johnson, Russell B Williams

J Am Chem Soc· August 2015

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Substrate controlled divergence in polyketide synthase catalysis.
Douglas A Hansen, Aaron A Koch, David H Sherman

J Am Chem Soc· March 2015

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Structure of a modular polyketide synthase.
Somnath Dutta, Jonathan R Whicher, Douglas A Hansen, Wendi A Hale, Joseph A Chemler

Nature· June 2014

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Structural rearrangements of a polyketide synthase module during its catalytic cycle.
Jonathan R Whicher, Somnath Dutta, Douglas A Hansen, Wendi A Hale, Joseph A Chemler

Nature· June 2014

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Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation.
Solymar Negretti, Alison R H Narayan, Karoline C Chiou, Petrea M Kells, Jessica L Stachowski, Douglas A Hansen

J Am Chem Soc· April 2014

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Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis.
Jonathan R Whicher, Sarah S Smaga, Douglas A Hansen, William C Brown, William H Gerwick

Chem Biol· November 2013

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Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin.
Douglas A Hansen, Christopher M Rath, Eli B Eisman, Alison R H Narayan, Jeffrey D Kittendorf

J Am Chem Soc· July 2013

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Electrochemical characterization of a bioceramic material: The shell of the Eastern oyster Crassostrea virginica.
Yuhchae Yoon, Andrew S Mount, Karolyn M Hansen, Douglas C Hansen

Bioelectrochemistry· June 2011

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Triple molecular target approach to selective melanoma cytotoxicity.
Edward B Skibo, Akmal Jamil, Brittany Austin, Douglas Hansen, Armand Ghodousi

Org Biomol Chem· April 2010

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Dynamic microcantilever sensors for discerning biomolecular interactions.
Fang Tian, Karolyn M Hansen, Thomas L Ferrell, Thomas Thundat, Douglas C Hansen

Anal Chem· March 2005

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Measurement and modeling of optical performance of wire grids and liquid-crystal displays utilizing grid polarizers.
Tatiana Sergan, Marina Lavrentovich, Jack Kelly, Eric Gardner, Douglas Hansen

J Opt Soc Am A Opt Image Sci Vis· September 2002

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