Publications by authors named "Dustin Dovala"

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A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1.
Antonin Tutter, Dennis Buckley, Andrei A Golosov, Xiaolei Ma, Wei Shu, Dustin Dovala

Nat Chem Biol· November 2025

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Sulfinyl Aziridines as Stereoselective Covalent Destabilizing Degraders of the Oncogenic Transcription Factor MYC.
Hannah T Rosen, Kelvin Li, Christian E Stieger, Erin L Li, Brynne Currier, Dustin Dovala

Angew Chem Int Ed Engl· November 2025

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Structural Analysis of Inhibitor Binding to the Feline Enteric Coronavirus (FECV) Main Protease.
Arooma Maryam, Stephanie A Moquin, Dustin Dovala, Jagroop Kaur, Nese Kurt Yilmaz

Viruses· November 2025

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Targeted Transcriptional Repression by Induced Proximity.
Christian E Stieger, Xinru Chen, Dustin Dovala, Fabian Wu, Nicolas Pizzato

bioRxiv· October 2025

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Cooperativity and Communication between the Active Sites of the Dimeric SARS-CoV-2 Main Protease.
Sarah N Zvornicanin, Ala M Shaqra, Julia Flynn, Lauren E Intravaia, Heidi Carias Martinez, Dustin Dovala

bioRxiv· July 2025

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Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50.
Sarah N Zvornicanin, Ala M Shaqra, Julia Flynn, Heidi Carias Martinez, Weiping Jia, Dustin Dovala

mBio· May 2025

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Sulfinyl Aziridines as Stereoselective Covalent Destabilizing Degraders of the Oncogenic Transcription Factor MYC.
Hannah T Rosen, Kelvin Li, Erin L Li, Brynne Currier, Scott M Brittain, Dustin Dovala

bioRxiv· February 2025

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Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness.
David T Barkan, Keira Garland, Lei Zhang, Richard T Eastman, Matthew Hesse, Dustin Dovala

J Med Chem· October 2024

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A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.
Pamela Y Ting, Sneha Borikar, John Ryan Kerrigan, Noel M Thomsen, Eamon Aghania, Dustin Dovala

Science· July 2024

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Ophiobolin A Covalently Targets Mitochondrial Complex IV Leading to Metabolic Collapse in Cancer Cells.
Flor A Gowans, Danny Q Thach, Zhouyang Zhu, Yangzhi Wang, Belen E Altamirano Poblano, Dustin Dovala

ACS Chem Biol· June 2024

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Contributions of Hyperactive Mutations in M from SARS-CoV-2 to Drug Resistance.
Julia M Flynn, Sarah N Zvornicanin, Tenzin Tsepal, Ala M Shaqra, Nese Kurt Yilmaz, Dustin Dovala

ACS Infect Dis· April 2024

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Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Xiaolei Ma, Barbara Leon, Elizabeth Ornelas, Dustin Dovala, Laura Tandeske

Sci Rep· December 2023

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Correction to "Rational Chemical Design of Molecular Glue Degraders".
Ethan S Toriki, James W Papatzimas, Kaila Nishikawa, Dustin Dovala, Andreas O Frank

ACS Cent Sci· August 2023

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Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease.
Julia M Flynn, Qiu Yu J Huang, Sarah N Zvornicanin, Gila Schneider-Nachum, Ala M Shaqra, Dustin Dovala

ACS Infect Dis· July 2023

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Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors.
Patrick Moon, Charlotte M Zammit, Qian Shao, Dustin Dovala, Lydia Boike

Chembiochem· June 2023

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Rational Chemical Design of Molecular Glue Degraders.
Ethan S Toriki, James W Papatzimas, Kaila Nishikawa, Dustin Dovala, Andreas O Frank

ACS Cent Sci· May 2023

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Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB.
Elizabeth A King, Yoojin Cho, Nathan S Hsu, Dustin Dovala, Jeffrey M McKenna

Cell Chem Biol· April 2023

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Targeted Protein Degradation through E2 Recruitment.
Nafsika Forte, Dustin Dovala, Matthew J Hesse, Jeffrey M McKenna, John A Tallarico

ACS Chem Biol· April 2023

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Ophiobolin A Covalently Targets Complex IV Leading to Mitochondrial Metabolic Collapse in Cancer Cells.
Flor A Gowans, Danny Q Thach, Yangzhi Wang, Belen E Altamirano Poblano, Dustin Dovala

bioRxiv· March 2023

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Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses.
Sarah N Zvornicanin, Ala M Shaqra, Qiuyu J Huang, Elizabeth Ornelas, Mallika Moghe, Dustin Dovala

Viruses· March 2023

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An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4.
Angel Gonzalez-Valero, Audrey G Reeves, Annika C S Page, Patrick J Moon, Edward Miller, Dustin Dovala

J Am Chem Soc· December 2022

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Comprehensive fitness landscape of SARS-CoV-2 M reveals insights into viral resistance mechanisms.
Julia M Flynn, Neha Samant, Gily Schneider-Nachum, David T Barkan, Nese Kurt Yilmaz, Dustin Dovala

Elife· June 2022

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Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Ala M Shaqra, Sarah N Zvornicanin, Qiu Yu J Huang, Gordon J Lockbaum, Mark Knapp, Dustin Dovala

Nat Commun· June 2022

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Deubiquitinase-targeting chimeras for targeted protein stabilization.
Nathaniel J Henning, Lydia Boike, Jessica N Spradlin, Carl C Ward, Gang Liu, Dustin Dovala

Nat Chem Biol· April 2022

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De novo Design of SARS-CoV-2 Main Protease Inhibitors.
Christian Fischer, Nynke A Vepřek, Zisis Peitsinis, Klaus-Peter Rühmann, Chao Yang, Dustin Dovala

Synlett· August 2021

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