Publications by authors named "Gordon J Lockbaum"

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Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement.
Brian A Sparling, Hyelee Lee, Mary-Margaret Zablocki, Maureen M Lynes, Simina Grigoriu, Gordon J Lockbaum

ACS Med Chem Lett· November 2025

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Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9.
Matthew H Daniels, Jennifer Castro, Young-Tae Lee, Deepali Gotur, Kevin E Knockenhauer, Gordon J Lockbaum

J Med Chem· May 2025

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Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.
Gordon J Lockbaum, Maureen M Lynes, Sophie A Shen, Julie Liu, Nicholas Holt

Commun Biol· April 2025

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HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues.
Gordon J Lockbaum, Linah N Rusere, Mina Henes, Klajdi Kosovrasti, Desaboini Nageswara Rao

Eur J Med Chem· September 2023

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Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance.
Ean Spielvogel, Sook-Kyung Lee, Shuntai Zhou, Gordon J Lockbaum, Mina Henes

Elife· March 2023

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Dual Inhibitors of Main Protease (M) and Cathepsin L as Potent Antivirals against SARS-CoV2.
Santanu Mondal, Yongzhi Chen, Gordon J Lockbaum, Sudeshna Sen, Sauradip Chaudhuri

J Am Chem Soc· November 2022

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Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Ala M Shaqra, Sarah N Zvornicanin, Qiu Yu J Huang, Gordon J Lockbaum, Mark Knapp

Nat Commun· June 2022

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Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.
Gordon J Lockbaum, Mina Henes, Jeong Min Lee, Jennifer Timm, Ellen A Nalivaika

Biochemistry· October 2021

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Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
Ashley N Matthew, Florian Leidner, Gordon J Lockbaum, Mina Henes, Jacqueto Zephyr

Chem Rev· March 2021

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Inhibiting HTLV-1 Protease: A Viable Antiviral Target.
Gordon J Lockbaum, Mina Henes, Nathaniel Talledge, Linah N Rusere, Klajdi Kosovrasti

ACS Chem Biol· March 2021

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Unique structural solution from a V3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Wayne D Harshbarger, Derrick Deming, Gordon J Lockbaum, Nattapol Attatippaholkun, Maliwan Kamkaew

Nat Commun· January 2021

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Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188.
Gordon J Lockbaum, Archie C Reyes, Jeong Min Lee, Ronak Tilvawala, Ellen A Nalivaika

Viruses· January 2021

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Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere.
Linah N Rusere, Gordon J Lockbaum, Mina Henes, Sook-Kyung Lee, Ean Spielvogel

J Med Chem· August 2020

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Optimizing the refinement of merohedrally twinned P6 HIV-1 protease-inhibitor cocrystal structures.
Gordon J Lockbaum, Florian Leidner, William E Royer, Nese Kurt Yilmaz, Celia A Schiffer

Acta Crystallogr D Struct Biol· March 2020

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Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors.
Ashley N Matthew, Jacqueto Zephyr, Desaboini Nageswara Rao, Mina Henes, Wasih Kamran, Gordon J Lockbaum

mBio· March 2020

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Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Mina Henes, Gordon J Lockbaum, Klajdi Kosovrasti, Florian Leidner, Gily S Nachum

ACS Chem Biol· November 2019

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Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Mina Henes, Klajdi Kosovrasti, Gordon J Lockbaum, Florian Leidner, Gily S Nachum

Biochemistry· September 2019

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HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope.
Linah N Rusere, Gordon J Lockbaum, Sook-Kyung Lee, Mina Henes, Klajdi Kosovrasti

J Med Chem· September 2019

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Correction to Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
Gordon J Lockbaum, Florian Leidner, Linah N Rusere, Mina Henes, Klajdi Kosovrasti

ACS Infect Dis· June 2019

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Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
Gordon J Lockbaum, Florian Leidner, Linah N Rusere, Mina Henes, Klajdi Kosovrasti

ACS Infect Dis· February 2019

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Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants.
Linah N Rusere, Ashley N Matthew, Gordon J Lockbaum, Muhammad Jahangir, Alicia Newton

ACS Med Chem Lett· July 2018

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