Publications by authors named "Ebbe Boedtkjer"

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Ketone bodies for hemodynamic support in acute pulmonary embolism: a randomized, blinded, controlled animal study.
Mads Dam Lyhne, Nigopan Gopalasingam, Kristoffer Berg-Hansen, Simone Juel Dragsbaek, Casper Homilius, Ebbe Boedtkjer

Intensive Care Med Exp· December 2025

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Loss of Na,HCO -Cotransporter NBCn1 Inhibits Net Acid Extrusion in the Atria and Causes Hypertension-Associated Cardiac Hypertrophy.
María S Espejo, Alejandro Orlowski, Trine M Sørensen, Vladimir V Matchkov, Ernesto A Aiello, Ebbe Boedtkjer

Acta Physiol (Oxf)· August 2025

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Dual-tracer autoradiographic analysis of glucose metabolism and hypoxia in orthotopic and PDX tumor models.
Morten Busk, Martin K Thomsen, Jens Overgaard, Martin F Berthelsen, Henrik Hager, Ebbe Boedtkjer

Acta Oncol· August 2025

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Lactate orchestrates metabolic hemodynamic adaptations through a unique combination of venocontraction, artery relaxation, and positive inotropy.
Casper Homilius, Jacob M Seefeldt, Jakob Hansen, Roni Nielsen, Frank V de Paoli, Ebbe Boedtkjer

Acta Physiol (Oxf)· May 2025

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Introducing a special issue: Acid-base regulation and sensing in health and disease.
Stine Falsig Pedersen, Ebbe Boedtkjer

Acta Physiol (Oxf)· April 2025

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Butyrate increases cardiac output and causes vasorelaxation in a healthy porcine model.
Lasse Juul Christensen, Alexander Møller Larsen, Casper Homilius, Nigopan Gopalasingam, Niels Moeslund, Ebbe Boedtkjer

Life Sci· February 2025

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Na/H-exchange inhibition by cariporide is compensated via Na,HCO-cotransport and has no net growth consequences for ErbB2-driven breast carcinomas.
Pernille Aaen, Kristoffer B Kristensen, Arththy Antony, Steen H Hansen, Claus Cornett, Ebbe Boedtkjer

Biochim Biophys Acta Mol Basis Dis· October 2024

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The electroneutral Na-HCO cotransporter NBCn1 (SLC4A7) modulates colonic enterocyte pH, proliferation, and migration.
Min Jiang, Azam Salari, Christian Stock, Katerina Nikolovska, Ebbe Boedtkjer

Am J Physiol Cell Physiol· June 2024

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Short-Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties.
Jacob Marthinsen Seefeldt, Casper Homilius, Jakob Hansen, Thomas Ravn Lassen, Nichlas Riise Jespersen, Ebbe Boedtkjer

J Am Heart Assoc· May 2024

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Antibodies toward Na,HCO-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer.
Trine V Axelsen, Claus Olesen, Danish Khan, Ali Mohammadi, Elena V Bouzinova, Ebbe Boedtkjer

Br J Cancer· April 2024

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Strengthening the basics: acids and bases influence vascular structure and function, tissue perfusion, blood pressure, and human cardiovascular disease.
Ebbe Boedtkjer, Tarannum Ara

Pflugers Arch· April 2024

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Enantiomer-Specific Cardiovascular Effects of the Ketone Body 3-Hydroxybutyrate.
Nigopan Gopalasingam, Niels Moeslund, Kristian Hylleberg Christensen, Kristoffer Berg-Hansen, Jacob Seefeldt, Ebbe Boedtkjer

J Am Heart Assoc· April 2024

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Carnosine facilitates lysosomal release of inhibitors of T cell surveillance.
Pawel Swietach, Marja Jäättelä, Shari Pillon-Thomas, Ebbe Boedtkjer

Cell Metab· March 2024

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How protons pave the way to aggressive cancers.
Pawel Swietach, Ebbe Boedtkjer, Stine Falsig Pedersen

Nat Rev Cancer· December 2023

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Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility.
Casper Homilius, Jacob Marthinsen Seefeldt, Julie Sørensen Axelsen, Tina Myhre Pedersen, Trine Monberg Sørensen, Ebbe Boedtkjer

Basic Res Cardiol· September 2023

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Stimulation of the Hydroxycarboxylic Acid Receptor 2 With the Ketone Body 3-Hydroxybutyrate and Niacin in Patients With Chronic Heart Failure: Hemodynamic and Metabolic Effects.
Nigopan Gopalasingam, Kristian Hylleberg Christensen, Kristoffer Berg Hansen, Roni Nielsen, Mogens Johannsen, Ebbe Boedtkjer

J Am Heart Assoc· June 2023

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Hemodynamic Effects of Ketone Bodies in Patients With Pulmonary Hypertension.
Roni Nielsen, Kristian Hylleberg Christensen, Nigopan Gopalasingam, Kristoffer Berg-Hansen, Jacob Seefeldt, Ebbe Boedtkjer

J Am Heart Assoc· May 2023

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Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer.
Soojung Lee, Nicolai J Toft, Trine V Axelsen, Maria Sofia Espejo, Tina M Pedersen, Ebbe Boedtkjer

Breast Cancer Res· April 2023

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Amplified Ca dynamics and accelerated cell proliferation in breast cancer tissue during purinergic stimulation.
Mikkel B Henningsen, Kezia McWhan, Vibeke S Dam, Marco Mele, Katrine R Hauerslev, Ebbe Boedtkjer

Int J Cancer· October 2022

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Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival.
Rasmus A Sloth, Trine V Axelsen, Maria Sofia Espejo, Nicolai J Toft, Ninna C S Voss, Ebbe Boedtkjer

Br J Cancer· October 2022

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Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression.
Ebbe Boedtkjer

Rev Physiol Biochem Pharmacol· April 2022

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The solution to bicarbonate.
Ebbe Boedtkjer, Christian Aalkjaer

Am J Physiol Heart Circ Physiol· April 2022

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Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival.
Nicolai J Toft, Trine V Axelsen, Helene L Pedersen, Marco Mele, Mark Burton, Ebbe Boedtkjer

Elife· July 2021

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NBCn1 Increases NH Reabsorption Across Thick Ascending Limbs, the Capacity for Urinary NH Excretion, and Early Recovery from Metabolic Acidosis.
Jeppe S M Olsen, Samuel Svendsen, Peder Berg, Vibeke S Dam, Mads V Sorensen, Ebbe Boedtkjer

J Am Soc Nephrol· April 2021

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Vaginal, Cervical and Uterine pH in Women with Normal and Abnormal Vaginal Microbiota.
Malene Risager Lykke, Naja Becher, Thor Haahr, Ebbe Boedtkjer, Jørgen Skov Jensen

Pathogens· January 2021

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