Publications by authors named "Edgar Otto"

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A renal biopsy-anchored multi-marker signature involving AOPEP SNP-driven splicing, miR-27b-3p and glycated albumin for stratifying renal damage in type 2 diabetes.
Francesca Conserva, Francesco Pesce, Claudia Cinefra, Tommaso Maria Marvulli, Ighli Di Bari, Edgar Otto

Diabetes Res Clin Pract· November 2025

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Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney.
Blue B Lake, Ricardo Melo Ferreira, Jens Hansen, Rajasree Menon, Jeannine Basta, Edgar A Otto

bioRxiv· November 2025

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Decreased parietal epithelial cell density is linked to podocyte depletion and predictors of kidney disease progression in human kidneys.
Jenna T Ference-Salo, Christopher L O'Connor, Rajasree Menon, Edgar A Otto, Meghan Dailey

Am J Physiol Renal Physiol· November 2025

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Corrigendum to "A renal biopsy-anchored multi-marker signature involving AOPEP SNP-driven splicing, miR-27b-3p and glycated albumin for stratifying renal damage in type 2 diabetes". [DIAB 229 (2025) 112460].
Francesca Conserva, Francesco Pesce, Claudia Cinefra, Tommaso Maria Marvulli, Ighli Di Bari, Edgar Otto

Diabetes Res Clin Pract· November 2025

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Liquid Biopsy-Multiomics Link Adhesion Pathway Dysregulation to Kidney Injury Severity.
Nanditha Anandakrishnan, Zhengzi Yi, Zeguo Sun, Tong Liu, Jonathan Haydak, Edgar A Otto

Kidney Int Rep· October 2025

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A Human Glomerular Disease Atlas defines the APOL1-JAK-STAT feed forward loop in focal segmental glomerulosclerosis.
Phillip J McCown, Charlotte Boys, Somenath Datta, Viji Nair, Edgar Otto

medRxiv· September 2025

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The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure.
Matthew Cusick, Viji Nair, Damian Fermin, John Hartman, Jeffrey A Beamish, Edgar Otto

JCI Insight· June 2025

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Parallel multiOMIC analysis reveals glutamine deprivation enhances directed differentiation of renal organoids.
Iman Sarami, Katherine E Hekman, Ashwani Kumar Gupta, Justin M Snider, David Ivancic, Edgar A Otto

bioRxiv· March 2025

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Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas.
Mario Acera-Mateos, Xian Adiconis, Jessica-Kanglin Li, Domenica Marchese, Ginevra Caratù, Edgar A Otto

bioRxiv· March 2025

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Not all controls are made equal: Definition of human kidney reference samples by single cell gene expression profiles.
Rajasree Menon, Paul L Kimmel, Edgar A Otto, Lalita Subramanian, Celine C Berthier

medRxiv· March 2025

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Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury.
Madison C McElliott, Asha C Telang, Jenna T Ference-Salo, Anas Al-Suraimi, Mahboob Chowdhury, Edgar A Otto

Am J Physiol Renal Physiol· January 2025

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Association of Urinary Epidermal Growth Factor, Fatty Acid-Binding Protein 3, and Vascular Cell Adhesion Molecule 1 Levels with the Progression of Early Diabetic Kidney Disease.
Felix Keller, Sara Denicolò, Johannes Leierer, Maren Kruus, Andreas Heinzel, Edgar Otto

Kidney Blood Press Res· December 2024

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Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease.
Abigail C Lay, Van Du T Tran, Viji Nair, Virginie Betin, Jennifer A Hurcombe, Edgar Otto

Nat Commun· November 2024

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Attenuated kidney oxidative metabolism in young adults with type 1 diabetes.
Ye Ji Choi, Gabriel Richard, Guanshi Zhang, Jeffrey B Hodgin, Dawit S Demeke, Edgar A Otto

J Clin Invest· October 2024

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Plasma Proteins Associated with Chronic Histopathologic Lesions on Kidney Biopsy.
Taesoo Kim, Aditya L Surapaneni, Insa M Schmidt, Michael T Eadon, Sahir Kalim, Edgar A Otto

J Am Soc Nephrol· July 2024

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Integrated multiomics implicates dysregulation of ECM and cell adhesion pathways as drivers of severe COVID-associated kidney injury.
Nanditha Anandakrishnan, Zhengzi Yi, Zeguo Sun, Tong Liu, Jonathan Haydak, Edgar A Otto

medRxiv· March 2024

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Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease.
Jeffrey A Beamish, Asha C Telang, Madison C McElliott, Anas Al-Suraimi, Mahboob Chowdhury, Edgar A Otto

Kidney Int· February 2024

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Sodium glucose co-transporter 2 inhibition increases epidermal growth factor expression and improves outcomes in patients with type 2 diabetes.
Taha Sen, Wenjun Ju, Viji Nair, Patricia Ladd, Rajasree Menon, Edgar A Otto

Kidney Int· October 2023

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Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients.
Kumar Sharma, Guanshi Zhang, Jens Hansen, Petter Bjornstad, Hak Joo Lee, Edgar A Otto

J Clin Invest· October 2023

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Pax Protein Depletion in Proximal Tubules Triggers Conserved Mechanisms of Resistance to Acute Ischemic Kidney Injury and Prevents Transition to Chronic Kidney Disease.
Jeffrey A Beamish, Asha C Telang, Madison C McElliott, Anas Al-Suraimi, Mahboob Chowdhury, Edgar A Otto

bioRxiv· October 2023

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Defining the molecular correlate of arteriolar hyalinosis in kidney disease progression by integration of single cell transcriptomic analysis and pathology scoring.
Rajasree Menon, Edgar A Otto, Laura Barisoni, Ricardo Melo Ferreira, Christine P Limonte

medRxiv· August 2023

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An atlas of healthy and injured cell states and niches in the human kidney.
Blue B Lake, Rajasree Menon, Seth Winfree, Qiwen Hu, Ricardo Melo Ferreira, Edgar A Otto

Nature· July 2023

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Role of endogenous adenine in kidney failure and mortality with diabetes.
Kumar Sharma, Guanshi Zhang, Jens Hansen, Petter Bjornstad, Hak Joo Lee, Edgar Otto

medRxiv· June 2023

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Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis.
Laura H Mariani, Sean Eddy, Fadhl M AlAkwaa, Phillip J McCown, Jennifer L Harder, Edgar A Otto

Kidney Int· March 2023

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SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes.
Jennifer A Schaub, Fadhl M AlAkwaa, Phillip J McCown, Abhijit S Naik, Viji Nair, Edgar A Otto

J Clin Invest· March 2023

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