Publications by authors named "Edith M Hessel"

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The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport.
Ashleigh Howes, Clare Rogerson, Nikolai Belyaev, Tina Karagyozova, Radu Rapiteanu, Edith M Hessel

Am J Respir Cell Mol Biol· September 2024

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In situ targeted base editing of bacteria in the mouse gut.
Andreas K Brödel, Loïc H Charpenay, Matthieu Galtier, Fabien J Fuche, Rémi Terrasse, Edith M Hessel

Nature· August 2024

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Genome-wide association study of susceptibility to hospitalised respiratory infections.
Alexander T Williams, Nick Shrine, Hardeep Naghra-van Gijzel, Joanna C Betts, Jing Chen, Edith M Hessel

Wellcome Open Res· November 2023

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Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.
Neil A Miller, Rebecca H Graves, Chris D Edwards, Augustin Amour, Ed Taylor, Edith M Hessel

Clin Pharmacokinet· February 2022

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PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation.
Sorif Uddin, Augustin Amour, David J Lewis, Chris D Edwards, Matthew G Williamson, Edith M Hessel

BMC Immunol· December 2021

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Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures.
Sabine Wronski, Soren Beinke, Helena Obernolte, Nikolai N Belyaev, Ken A Saunders, Edith M Hessel

Am J Respir Cell Mol Biol· November 2021

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Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.
Kenneth Down, Augustin Amour, Niall A Anderson, Nick Barton, Sebastien Campos, Edith M Hessel

J Med Chem· September 2021

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An Inhaled PI3Kδ Inhibitor Improves Recovery in Acutely Exacerbating COPD Patients: A Randomized Trial.
Anthony Cahn, J Nicole Hamblin, Jon Robertson, Malcolm Begg, Emily Jarvis, Edith M Hessel

Int J Chron Obstruct Pulmon Dis· August 2021

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Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials.
Malcolm Begg, J Nicole Hamblin, Emily Jarvis, Glyn Bradley, Stephen Mark, Edith M Hessel

Int J Chron Obstruct Pulmon Dis· August 2021

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Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study.
William A Fahy, Farshid Homayoun-Valiani, Anthony Cahn, Jon Robertson, Alison Templeton, Edith M Hessel

Int J Chron Obstruct Pulmon Dis· August 2021

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Predicting Re-Exacerbation Timing and Understanding Prolonged Exacerbations: An Analysis of Patients with COPD in the ECLIPSE Cohort.
Wilhelmine H Meeraus, Hana Mullerova, Céline El Baou, Marion Fahey, Edith M Hessel

Int J Chron Obstruct Pulmon Dis· June 2021

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Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages.
Ashley R Ambrose, Susanne Dechantsreiter, Rajesh Shah, M Angeles Montero, Anne Marie Quinn, Edith M Hessel

Biophys J· December 2020

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Intranasal Bifidobacterium longum protects against viral-induced lung inflammation and injury in a murine model of lethal influenza infection.
David Groeger, Elisa Schiavi, Ray Grant, Magdalena Kurnik-Łucka, David Michalovich, Edith M Hessel

EBioMedicine· October 2020

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Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface.
Radu Rapiteanu, Tina Karagyozova, Natalie Zimmermann, Kuljit Singh, Gareth Wayne, Edith M Hessel

Eur Respir J· May 2020

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Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations.
Aarti Patel, Robert Wilson, Andrew W Harrell, Kunal S Taskar, Maxine Taylor, Edith M Hessel

Drug Metab Dispos· April 2020

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Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.
Helena Aegerter, Justina Kulikauskaite, Stefania Crotta, Harshil Patel, Gavin Kelly, Edith M Hessel

Nat Immunol· February 2020

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Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target.
Zoë A Henley, Augustin Amour, Nick Barton, Marcus Bantscheff, Giovanna Bergamini, Edith M Hessel

J Med Chem· January 2020

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An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects.
Andrew W Harrell, Robert Wilson, Yau Lun Man, Kylie Riddell, Emily Jarvis, Edith M Hessel

Drug Metab Dispos· December 2019

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Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.
David Michalovich, Noelia Rodriguez-Perez, Sylwia Smolinska, Michal Pirozynski, David Mayhew, Edith M Hessel

Nat Commun· December 2019

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Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage.
Braulio Henrique Freire Lima, Pedro Elias Marques, Lindisley Ferreira Gomides, Matheus Silvério Mattos, Lucas Kraemer, Edith M Hessel

Sci Rep· December 2019

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Use of autologous Technetium-labelled neutrophils to quantify lung neutrophil clearance in COPD.
Nicola Tregay, Malcolm Begg, Anthony Cahn, Neda Farahi, Kathryn Povey, Edith M Hessel

Thorax· July 2019

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Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase Inhibitor.
Malcolm Begg, Chris D Edwards, J Nicole Hamblin, Eleni Pefani, Robert Wilson, Edith M Hessel

J Pharmacol Exp Ther· June 2019

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Safety, Tolerability, and Pharmacokinetics of a New Formulation of Nemiralisib Administered via a Dry Powder Inhaler to Healthy Individuals.
Robert Wilson, Alison Templeton, Claudia Leemereise, Rhena Eames, Edward Banham-Hall, Edith M Hessel

Clin Ther· June 2019

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Airway host-microbiome interactions in chronic obstructive pulmonary disease.
Zhang Wang, Barbara Maschera, Simon Lea, Umme Kolsum, David Michalovich, Edith M Hessel

Respir Res· June 2019

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A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma.
Sanjeev Khindri, Anthony Cahn, Malcolm Begg, Mickael Montembault, Claudia Leemereise, Edith M Hessel

J Pharmacol Exp Ther· December 2018

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