Publications by authors named "Edith Monteagudo"

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Orthosteric inhibition of MutSβ ATPase function: First disclosure of MSH3-bound small molecule inhibitors.
Gareth N Brace, Karsten Tillack, Peter D Johnson, Markus Ritzefeld, Sabine Schaertl, Edith Monteagudo

Bioorg Med Chem Lett· December 2025

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Post-translational modifications of huntingtin's N17 region: implications for self-association and membrane binding.
Mariana Gallo, Raffaele Ingenito, Marco Finotto, Sara Di Marino, Daniel Cicero, Edith Monteagudo

Biochim Biophys Acta Mol Basis Dis· November 2025

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Elucidation of multiple high-resolution states of human MutSβ by cryo-EM reveals interplay between ATP/ADP binding and heteroduplex DNA recognition.
Jung-Hoon Lee, Maren Thomsen, Herwin Daub, Gabriel Thieulin-Pardo, Stefan Steinbacher, Edith Monteagudo

Nucleic Acids Res· June 2025

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A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA.
Jonas Aretz, Gayathri Jeyasankar, Anna Salerno-Kochan, Maren Thomsen, Gabriel Thieulin-Pardo, Edith Monteagudo

Nat Commun· May 2025

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Optimization of Single Relaxin B-Chain Peptide Leads to the Identification of R2R01, a Potent, Long-Acting RXFP1 Agonist for Cardiovascular and Renal Diseases.
Sergio Mallart, Raffaele Ingenito, Paola Magotti, Alberto Bresciani, Annalise Di Marco, Edith Monteagudo

J Med Chem· February 2025

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Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.
Longbin Liu, Karine Malagu, Alan F Haughan, Vinod Khetarpal, Andrew J Stott, Edith Monteagudo

J Med Chem· September 2023

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The Urine Metabolome of R6/2 and zQ175DN Huntington's Disease Mouse Models.
Roberto Speziale, Camilla Montesano, Giulia Di Pietro, Daniel Oscar Cicero, Vincenzo Summa, Edith Monteagudo

Metabolites· August 2023

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Fatty acid acylated peptide therapeutics: discovery of omega-n oxidation of the lipid chain as a novel metabolic pathway in preclinical species.
Simone Esposito, Alain Krick, Olivier Pasquier, Fabrice Bonche, Raffaele Ingenito, Edith Monteagudo

J Pharm Biomed Anal· April 2023

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Design and Evaluation of [F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates.
Longbin Liu, Peter D Johnson, Michael E Prime, Vinod Khetarpal, Christopher J Brown, Edith Monteagudo

J Med Chem· January 2023

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Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.
Stephane Illiano, Bruno Poirier, Claire Minoletti, Olivier Pasquier, Laurence Riva, Edith Monteagudo

Sci Rep· November 2022

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Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators.
Leda Ivanova Bencheva, Lorena Donnici, Luca Ferrante, Adolfo Prandi, Roberta Sinisi, Edith Monteagudo

Bioorg Med Chem Lett· October 2022

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Identification and in vitro characterization of a new series of potent and highly selective G9a inhibitors as novel anti-fibroadipogenic agents.
Pietro Randazzo, Roberta Sinisi, Davide Gornati, Stefania Bertuolo, Leda Bencheva, Edith Monteagudo

Bioorg Med Chem Lett· September 2022

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Oligomerization, albumin binding and catabolism of therapeutic peptides in the subcutaneous compartment: An investigation on lipidated GLP-1 analogs.
Mariana Gallo, Domitilla Vanni, Simone Esposito, Nadine Alaimo, Federica Orvieto, Edith Monteagudo

J Pharm Biomed Anal· February 2022

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Turnover rate of coenzyme A in mouse brain and liver.
Laura Orsatti, Maria Vittoria Orsale, Pamela di Pasquale, Andrea Vecchi, Fabrizio Colaceci, Edith Monteagudo

PLoS One· October 2021

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Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease.
Laura Orsatti, Thomas Stiehl, Katharina Dischinger, Roberto Speziale, Pamela Di Pasquale, Edith Monteagudo

Cell Rep Med· October 2021

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[C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins.
Longbin Liu, Peter D Johnson, Michael E Prime, Vinod Khetarpal, Matthew R Lee, Edith Monteagudo

J Med Chem· August 2021

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Personalized Metabolic Profile by Synergic Use of NMR and HRMS.
Greta Petrella, Camilla Montesano, Sara Lentini, Giorgia Ciufolini, Domitilla Vanni, Edith Monteagudo

Molecules· July 2021

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Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases.
Sergio Mallart, Raffaele Ingenito, Elisabetta Bianchi, Alberto Bresciani, Simone Esposito, Edith Monteagudo

J Med Chem· February 2021

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Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration.
Giulio Auciello, Annalise Di Marco, Odalys Gonzalez Paz, Savina Malancona, Steven Harper, Edith Monteagudo

J Med Chem· December 2020

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Comparison of different protein precipitation and solid-phase extraction protocols for the study of the catabolism of peptide drugs by LC-HRMS.
Simone Esposito, Domitilla Vanni, Sergio Menta, Laura Orsatti, Edith Monteagudo

J Pept Sci· September 2020

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Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand.
Longbin Liu, Michael E Prime, Matt R Lee, Vinod Khetarpal, Christopher J Brown, Edith Monteagudo

J Med Chem· August 2020

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5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein.
Savina Malancona, Mattia Mori, Paola Fezzardi, Marisabella Santoriello, Andreina Basta, Edith Monteagudo

ACS Med Chem Lett· May 2020

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Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System.
Annalise Di Marco, Domenico Vignone, Odalys Gonzalez Paz, Ivan Fini, Maria Rosaria Battista, Edith Monteagudo

Cells· April 2020

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Synthesis and Biological Evaluation of RGD⁻Cryptophycin Conjugates for Targeted Drug Delivery.
Adina Borbély, Eduard Figueras, Ana Martins, Simone Esposito, Giulio Auciello, Edith Monteagudo

Pharmaceutics· April 2019

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Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides.
Alberto Bresciani, Jesus M Ontoria, Ilaria Biancofiore, Antonella Cellucci, Alina Ciammaichella, Edith Monteagudo

ACS Med Chem Lett· April 2019

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