Publications by authors named "Edith Sim"

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Fusarium verticillioides NAT1 (FDB2) N-malonyltransferase is structurally, functionally and phylogenetically distinct from its N-acetyltransferase (NAT) homologues.
Eleni-Pavlina Karagianni, Evanthia Kontomina, Edward D Lowe, Konstantinos Athanasopoulos, Georgia Papanikolaou, Robert B Sim, Edith Sim

FEBS J· May 2023

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Intrinsic chemical reactivity of activated human complement component C3: A historical glimpse into research during 1979-1980 on the covalent binding properties of C3, C4 and alpha-2 macroglobulin.
Robert Sim, Trevor M Twose, Edith Sim, K B M Reid

Immunobiology· July 2022

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Comparative analysis of xenobiotic metabolising N-acetyltransferases from ten non-human primates as in vitro models of human homologues.
Theodora Tsirka, Maria Konstantopoulou, Audrey Sabbagh, Brigitte Crouau-Roy, Ali Ryan, Edith Sim

Sci Rep· June 2018

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Recent progress in N-acetyltransferase research: 7th international workshop on N-acetyltransferases (NAT): workshop report.
Jutta Lichter, Klaus Golka, Edith Sim, Brunhilde Blömeke

Arch Toxicol· July 2017

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Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.
Ali Ryan, Elena Polycarpou, Nathan A Lack, Dimitrios Evangelopoulos, Christian Sieg, Edith Sim

Br J Pharmacol· July 2017

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Drug metabolism and antibiotic resistance in micro-organisms.
Edith Sim, Ali Ryan

Br J Pharmacol· July 2017

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Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.
Paul Fineran, Emyr Lloyd-Evans, Nathan A Lack, Nick Platt, Lianne C Davis, Simon Clark, Edith Sim

Wellcome Open Res· November 2016

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Identification of novel members of the bacterial azoreductase family in Pseudomonas aeruginosa.
Vincenzo Crescente, Sinead M Holland, Sapna Kashyap, Elena Polycarpou, Edith Sim

Biochem J· March 2016

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Identification of NAD(P)H quinone oxidoreductase activity in azoreductases from P. aeruginosa: azoreductases and NAD(P)H quinone oxidoreductases belong to the same FMN-dependent superfamily of enzymes.
Ali Ryan, Elise Kaplan, Jean-Christophe Nebel, Elena Polycarpou, Vincenzo Crescente, Edith Sim

PLoS One· October 2015

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Homologues of xenobiotic metabolizing N-acetyltransferases in plant-associated fungi: Novel functions for an old enzyme family.
Eleni P Karagianni, Evanthia Kontomina, Britton Davis, Barbara Kotseli, Theodora Tsirka, Edith Sim

Sci Rep· August 2015

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From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2.
Nicola Laurieri, Julien Dairou, James E Egleton, Lesley A Stanley, Angela J Russell, Edith Sim

PLoS One· January 2015

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Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis.
Dimitrios Evangelopoulos, Antima Gupta, Nathan A Lack, Arundhati Maitra, Annemieke M C ten Bokum, Edith Sim

Tuberculosis (Edinb)· December 2014

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Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding.
Nicola Laurieri, Akane Kawamura, Isaac M Westwood, Amy Varney, Elizabeth Morris, Edith Sim

BMC Pharmacol Toxicol· November 2014

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Exploration of piperidinols as potential antitubercular agents.
Areej Abuhammad, Elizabeth Fullam, Sanjib Bhakta, Angela J Russell, Garrett M Morris, Edith Sim

Molecules· October 2014

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Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1.
James E Egleton, Cyrille C Thinnes, Peter T Seden, Nicola Laurieri, Siu Po Lee, Edith Sim

Bioorg Med Chem· June 2014

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A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1.
Nicola Laurieri, James E Egleton, Amy Varney, Cyrille C Thinnes, Camilo E Quevedo, Edith Sim

PLoS One· March 2014

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Mechanism-based inhibition of HsaD: a C-C bond hydrolase essential for survival of Mycobacterium tuberculosis in macrophage.
Ali Ryan, Sebastian Keany, Olga Eleftheriadou, Romain Ballet, Hung-Yuan Cheng, Edith Sim

FEMS Microbiol Lett· January 2014

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Activation of nitrofurazone by azoreductases: multiple activities in one enzyme.
Ali Ryan, Elise Kaplan, Nicola Laurieri, Edward Lowe, Edith Sim

Sci Rep· August 2013

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Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity.
Areej Abuhammad, Edward D Lowe, Michael A McDonough, Patrick D Shaw Stewart, Stefan A Kolek, Edith Sim

Acta Crystallogr D Biol Crystallogr· August 2013

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Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.
Areej Abuhammad, Elizabeth Fullam, Edward D Lowe, David Staunton, Akane Kawamura, Edith Sim

PLoS One· June 2013

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Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.
Elizabeth Fullam, James Talbot, Areej Abuhammed, Isaac Westwood, Stephen G Davies, Edith Sim

Bioorg Med Chem Lett· May 2013

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Arylamine N-acetyltransferases--from drug metabolism and pharmacogenetics to identification of novel targets for pharmacological intervention.
Edith Sim, Giannoulis Fakis, Nicola Laurieri, Sotiria Boukouvala

Adv Pharmacol· November 2012

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Gene expression profiling of primary male breast cancers reveals two unique subgroups and identifies N-acetyltransferase-1 (NAT1) as a novel prognostic biomarker.
Ida Johansson, Cecilia Nilsson, Pontus Berglund, Martin Lauss, Markus Ringnér, Edith Sim

Breast Cancer Res· February 2012

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Improvement of the expression and purification of Mycobacterium tuberculosis arylamine N-acetyltransferase (TBNAT) a potential target for novel anti-tubercular agents.
Areej Abuhammad, Nathan Lack, Judith Schweichler, David Staunton, Robert B Sim, Edith Sim

Protein Expr Purif· December 2011

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Characterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium smegmatis.
Dimitrios Evangelopoulos, Nora Cronin, Tina Daviter, Edith Sim, Nicholas H Keep

FEBS J· December 2011

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