Publications by authors named "Edward Fon"

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Basic Science and Pathogenesis.
Latiyah Tc Timothy, Vladislav Novikov, Kellly Summers, Thomas M Durcan, Edward A Fon

Alzheimers Dement· December 2025

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α-Synuclein purification significantly impacts seed amplification assay performance and consistency.
Zaid A M Al-Azzawi, Nicholas R G Silver, Surabhi Mehra, Simeng Niu, Christopher Situ, Edward A Fon

Acta Neuropathol Commun· November 2025

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Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils.
Benoît Vanderperre, Amitha Muraleedharan, Marie-France Dorion, Frédérique Larroquette, Esther Del Cid Pellitero, Edward A Fon

Commun Biol· October 2025

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Neural networks reveal novel gene signatures in Parkinson disease from single-nuclei transcriptomes.
Michael R Fiorini, Jialun Li, Edward A Fon, Sali M K Farhan, Rhalena A Thomas

NPJ Parkinsons Dis· October 2025

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Substrate recognition by the human mitochondrial processing peptidase and its processing of PINK1.
Andrew N Bayne, Danielle M Simons, Naoto Soya, Karl Grenier, Gergely L Lukacs, Edward A Fon

J Biol Chem· October 2025

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Ensemblex: an accuracy-weighted ensemble genetic demultiplexing framework for population-scale scRNAseq sample pooling.
Michael R Fiorini, Saeid Amiri, Allison A Dilliott, Cristine M Yde Ohki, Lukasz Smigielski, Edward A Fon

Genome Biol· July 2025

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Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligase.
Fabienne C Fiesel, Bernardo A Bustillos, Jens O Watzlawik, Carol X Q Chen, Martin H Berryer, Edward A Fon

Autophagy· July 2025

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Cell biology: Mitochondrial protease degrades unoccupied translocases upon import stress.
Mohamed A Eldeeb, Michael Shahid, Edward A Fon

Curr Biol· April 2025

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LRRK2 rare-variant per-domain genetic burden in Parkinson's Disease: association confined to the kinase domain.
Sitki Cem Parlar, Konstantin Senkevich, Eric Yu, Jennifer A Ruskey, Jamil Ahmad, Edward A Fon

NPJ Parkinsons Dis· April 2025

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Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease.
Alex I Wiesman, Victoria Madge, Edward A Fon, Alain Dagher, D Louis Collins

Brain· March 2025

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AMPK-dependent Parkin activation suppresses macrophage antigen presentation to promote tumor progression.
Xinyu Wang, Yiyi Li, Yan Li, Xiumei Wang, Hongrui Song, Edward A Fon

Sci Adv· March 2025

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Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Claudia Tredup, Suzanne Ackloo, Hartmut Beck, Peter J Brown, Alex N Bullock, Edward A Fon

RSC Med Chem· February 2025

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Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils.
Stephanie Tullo, Janice Sung Hyun Park, Daniel Gallino, Megan Park, Kristie Mar, Edward A Fon

Commun Biol· February 2025

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Cell type transcriptomics reveal shared genetic mechanisms in Alzheimer's and Parkinson's disease.
Anwesha Bhattacharya, Edward A Fon, Alain Dagher, Yasser Iturria-Medina, Jo Anne Stratton

bioRxiv· February 2025

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Disease-modifying therapies for Parkinson disease: lessons from multiple sclerosis.
Lorraine V Kalia, Angelica Asis, Nathalie Arbour, Amit Bar-Or, Riley Bove, Edward A Fon

Nat Rev Neurol· December 2024

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Modeling Parkinson's disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines.
Armin Bayati, Riham Ayoubi, Adriana Aguila, Cornelia E Zorca, Ghislaine Deyab, Edward A Fon

Nat Neurosci· December 2024

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Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA).
Howard Chertkow, Natalie Phillips, Kenneth Rockwood, Nicole Anderson, Melissa K Andrew, Edward Fon

J Alzheimers Dis· December 2024

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Correction: The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.
Jace Jones-Tabah, Kathy He, Nathan Karpilovsky, Konstantin Senkevich, Ghislaine Deyab, Edward A Fon

Mol Neurodegener· December 2024

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The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.
Jace Jones-Tabah, Kathy He, Nathan Karpilovsky, Konstantin Senkevich, Ghislaine Deyab, Edward A Fon

Mol Neurodegener· November 2024

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Advancing Parkinson's Disease Research in Canada: The Canadian Open Parkinson Network (C-OPN) Cohort.
Marisa Cressatti, Gabriel D Pinilla-Monsalve, Mathieu Blais, Catherine P Normandeau, Clotilde Degroot, Edward A Fon

J Parkinsons Dis· October 2024

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ScRNAbox: empowering single-cell RNA sequencing on high performance computing systems.
Rhalena A Thomas, Michael R Fiorini, Saeid Amiri, Edward A Fon, Sali M K Farhan

BMC Bioinformatics· October 2024

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CelltypeR: A flow cytometry pipeline to characterize single cells from brain organoids.
Rhalena A Thomas, Julien Sirois, Shuming Li, Alexandre Gestin, Ghislaine Deyab, Edward A Fon

iScience· September 2024

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Activation of parkin by a molecular glue.
Véronique Sauvé, Eric Stefan, Nathalie Croteau, Thomas Goiran, Rayan Fakih, Edward A Fon

Nat Commun· September 2024

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Mitochondrial import stress and PINK1-mediated mitophagy: the role of the PINK1-TOMM-TIMM23 supercomplex.
Mohamed A Eldeeb, Armaan Fallahi, Andrea Soumbasis, Andrew N Bayne, Jean-François Trempe, Edward A Fon

Autophagy· August 2024

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