Publications by authors named "Edward Spooner"

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Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Wonsuk Chang, Michael D Altman, Charles A Lesburg, Samanthi A Perera, Jennifer A Piesvaux, Edward Spooner

J Med Chem· April 2022

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Identification of Kinases Responsible for p53-Dependent Autophagy.
Stephanie L Celano, Lisette P Yco, Matthew G Kortus, Abigail R Solitro, Hakan Gunaydin, Edward Spooner

iScience· May 2019

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A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit.
Johnny Kopinja, Raquel S Sevilla, Diane Levitan, David Dai, Amy Vanko, Edward Spooner

Sci Rep· October 2017

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Inhibiting aurora kinases reduces tumor growth and suppresses tumor recurrence after chemotherapy in patient-derived triple-negative breast cancer xenografts.
Angela Romanelli, Anderson Clark, Franck Assayag, Sophie Chateau-Joubert, Marie-France Poupon, Edward Spooner

Mol Cancer Ther· December 2012

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Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.
Ganesh M Shankar, Malcolm A Leissring, Anthony Adame, Xiaoyan Sun, Edward Spooner

Neurobiol Dis· November 2009

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Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice.
Timothy J Seabrook, Katelyn Thomas, Liying Jiang, Jeanne Bloom, Edward Spooner

Neurobiol Aging· June 2007

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Multiple endocrine neoplasia 2A due to a unique C609S RET mutation presents with pheochromocytoma and reduced penetrance of medullary thyroid carcinoma.
William B Kinlaw, Sarah M Scott, Robert A Maue, Vincent A Memoli, Robert D Harris, Edward T Spooner

Clin Endocrinol (Oxf)· December 2005

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Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.
Igor Klyubin, Dominic M Walsh, Cynthia A Lemere, William K Cullen, Ganesh M Shankar, Edward T Spooner

Nat Med· May 2005

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Species-specific immune response to immunization with human versus rodent A beta peptide.
Timothy J Seabrook, Jeanne K Bloom, Melitza Iglesias, Edward T Spooner, Dominic M Walsh

Neurobiol Aging· October 2004

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Differences in the immune response to long term Abeta vaccination in C57BL/6 and B6D2F1 mice.
Timothy J Seabrook, Melitza Iglesias, Jeanne K Bloom, Edward T Spooner, Cynthia A Lemere

Vaccine· September 2004

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Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet.
Cynthia A Lemere, Amy Beierschmitt, Melitza Iglesias, Edward T Spooner, Jeanne K Bloom

Am J Pathol· July 2004

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Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.
Cynthia A Lemere, Edward T Spooner, John LaFrancois, Brian Malester, Chica Mori

Neurobiol Dis· October 2003

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Amyloid-beta immunization in Alzheimer's disease transgenic mouse models and wildtype mice.
Cynthia A Lemere, Edward T Spooner, Jodi F Leverone, Chica Mori, Melitza Iglesias

Neurochem Res· July 2003

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Abeta1-15 is less immunogenic than Abeta1-40/42 for intranasal immunization of wild-type mice but may be effective for "boosting".
Jodi F Leverone, Edward T Spooner, Herman K Lehman, John D Clements, Cynthia A Lemere

Vaccine· May 2003

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Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants.
Cynthia A Lemere, Edward T Spooner, Jodi F Leverone, Chica Mori, John D Clements

Neurobiol Aging· March 2003

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The generation and characterization of potentially therapeutic Abeta antibodies in mice: differences according to strain and immunization protocol.
Edward T Spooner, Roanak V Desai, Chica Mori, Jodi F Leverone, Cynthia A Lemere

Vaccine· December 2002

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Intraneuronal Abeta42 accumulation in Down syndrome brain.
Chica Mori, Edward T Spooner, Krystyna E Wisniewsk, Thomas M Wisniewski, Haruyasu Yamaguch

Amyloid· June 2002

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