Publications by authors named "Eiichi Fuse"

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Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human.
Jun Hosogi, Rui Ohashi, Hiroshi Maeda, Satoshi Tashiro, Eiichi Fuse

Drug Metab Pharmacokinet· October 2017

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Quantitative investigation of the brain-to-cerebrospinal fluid unbound drug concentration ratio under steady-state conditions in rats using a pharmacokinetic model and scaling factors for active efflux transporters.
Hiroshi Kodaira, Hiroyuki Kusuhara, Eiichi Fuse, Junko Ushiki, Yuichi Sugiyama

Drug Metab Dispos· June 2014

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Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate.
Hiroshi Kodaira, Hiroyuki Kusuhara, Takuya Fujita, Junko Ushiki, Eiichi Fuse

J Pharmacol Exp Ther· December 2011

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Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.
Hiroshi Kodaira, Hiroyuki Kusuhara, Junko Ushiki, Eiichi Fuse, Yuichi Sugiyama

J Pharmacol Exp Ther· June 2010

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Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors.
Hiroshi Ishida, Shoichi Isami, Tsutomu Matsumura, Hiroshi Umehara, Yoshinori Yamashita, Eiichi Fuse

Bioorg Med Chem Lett· October 2008

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P-glycoprotein limits the brain penetration of olopatadine hydrochloride, H1-receptor antagonist.
Nobuhito Mimura, Yoshinori Nagata, Takashi Kuwabara, Nobuo Kubo, Eiichi Fuse

Drug Metab Pharmacokinet· May 2008

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Synthetic study of VLA-4/VCAM-1 inhibitors: synthesis and structure-activity relationship of piperazinylphenylalanine derivatives.
Osamu Saku, Kiminori Ohta, Eri Arai, Yuji Nomoto, Hiroko Miura, Eiichi Fuse

Bioorg Med Chem Lett· February 2008

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Effect of benidipine on simvastatin metabolism in human liver microsomes.
Yuka Sugiyama, Nobuhito Mimura, Takashi Kuwabara, Hiroyuki Kobayashi, Junko Ushiki, Eiichi Fuse

Drug Metab Pharmacokinet· June 2007

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Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid.
Harunobu Tahara, Hiroyuki Kusuhara, Kazuya Maeda, Hermann Koepsell, Eiichi Fuse

Drug Metab Dispos· May 2006

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Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists.
Harunobu Tahara, Hiroyuki Kusuhara, Michihiro Chida, Eiichi Fuse, Yuichi Sugiyama

J Pharmacol Exp Ther· March 2006

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A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters.
Harunobu Tahara, Hiroyuki Kusuhara, Hitoshi Endou, Hermann Koepsell, Tomoki Imaoka, Eiichi Fuse

J Pharmacol Exp Ther· October 2005

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Inhibitory effect of the 4-aminotetrahydroquinoline derivatives, selective chemoattractant receptor-homologous molecule expressed on T helper 2 cell antagonists, on eosinophil migration induced by prostaglandin D2.
Hideki Mimura, Toshihide Ikemura, Osamu Kotera, Masatsugu Sawada, Satoshi Tashiro, Eiichi Fuse

J Pharmacol Exp Ther· July 2005

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P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion.
Harunobu Tahara, Hiroyuki Kusuhara, Eiichi Fuse, Yuichi Sugiyama

Drug Metab Dispos· July 2005

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Review of UCN-01 development: a lesson in the importance of clinical pharmacology.
Eiichi Fuse, Takashi Kuwabara, Alex Sparreboom, Edward A Sausville, William D Figg

J Clin Pharmacol· April 2005

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Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney.
Harunobu Tahara, Masayuki Shono, Hiroyuki Kusuhara, Hajime Kinoshita, Eiichi Fuse

Pharm Res· April 2005

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The contribution of cytochrome P450 to the metabolism of tegafur in human liver.
Jiro Kajita, Eiichi Fuse, Takashi Kuwabara, Hiroyuki Kobayashi

Drug Metab Pharmacokinet· March 2005

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Clinical pharmacology and pharmacogenetics of flavopiridol 1-h i.v. infusion in patients with refractory neoplasms.
Suoping Zhai, Edward A Sausville, Adrian M Senderowicz, Yuichi Ando, Donna Headlee, Eiichi Fuse

Anticancer Drugs· February 2003

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Effects of olopatadine, a new antiallergic agent, on human liver microsomal cytochrome P450 activities.
Jiro Kajita, Keiko Inano, Eiichi Fuse, Takashi Kuwabara, Hiroyuki Kobayashi

Drug Metab Dispos· December 2002

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Thalidomide metabolism by the CYP2C subfamily.
Yuichi Ando, Eiichi Fuse, William D Figg

Clin Cancer Res· June 2002

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