Publications by authors named "Eileen Jaffe"

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Manipulation of a cation-π sandwich reveals conformational flexibility in phenylalanine hydroxylase.
Emilia C Arturo, George W Merkel, Michael R Hansen, Sophia Lisowski, Deeanne Almeida, Eileen K Jaffe

Biochimie· April 2021

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Porphobilinogen synthase: An equilibrium of different assemblies in human health.
Eileen K Jaffe

Prog Mol Biol Transl Sci· December 2020

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Wrangling Shape-Shifting Morpheeins to Tackle Disease and Approach Drug Discovery.
Eileen K Jaffe

Front Mol Biosci· November 2020

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Biophysical characterization of full-length human phenylalanine hydroxylase provides a deeper understanding of its quaternary structure equilibrium.
Emilia C Arturo, Kushol Gupta, Michael R Hansen, Elias Borne, Eileen K Jaffe

J Biol Chem· June 2019

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Simulations of the regulatory ACT domain of human phenylalanine hydroxylase (PAH) unveil its mechanism of phenylalanine binding.
Yunhui Ge, Elias Borne, Shannon Stewart, Michael R Hansen, Emilia C Arturo, Eileen K Jaffe

J Biol Chem· December 2018

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New protein structures provide an updated understanding of phenylketonuria.
Eileen K Jaffe

Mol Genet Metab· August 2017

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The Remarkable Character of Porphobilinogen Synthase.
Eileen K Jaffe

Acc Chem Res· November 2016

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First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer.
Emilia C Arturo, Kushol Gupta, Annie Héroux, Linda Stith, Penelope J Cross, Eileen K Jaffe

Proc Natl Acad Sci U S A· March 2016

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Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization.
Ursula D Ramirez, Anna S Nikonova, Hanqing Liu, Anna Pecherskaya, Sarah H Lawrence, Eileen K Jaffe

BMC Cancer· May 2015

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wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs.
Christian S Lentz, Victoria S Halls, Jeffrey S Hannam, Silke Strassel, Sarah H Lawrence, Eileen K Jaffe

J Med Chem· March 2014

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Impact of quaternary structure dynamics on allosteric drug discovery.
Eileen K Jaffe

Curr Top Med Chem· September 2013

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A new model for allosteric regulation of phenylalanine hydroxylase: implications for disease and therapeutics.
Eileen K Jaffe, Linda Stith, Sarah H Lawrence, Mark Andrake, Roland L Dunbrack

Arch Biochem Biophys· February 2013

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Environmental contaminants perturb fragile protein assemblies and inhibit normal protein function.
Sarah H Lawrence, Trevor Selwood, Eileen K Jaffe

Curr Chem Biol· January 2013

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Facile Synthesis of Mutagen X (MX): 3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one.
Venkata Velvadapu, Mark E McDonnell, Eileen K Jaffe, Allen B Reitz

Tetrahedron Lett· June 2012

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The morpheein model of allostery: evaluating proteins as potential morpheeins.
Eileen K Jaffe, Sarah H Lawrence

Methods Mol Biol· May 2012

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Allostery and the dynamic oligomerization of porphobilinogen synthase.
Eileen K Jaffe, Sarah H Lawrence

Arch Biochem Biophys· March 2012

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Dynamic dissociating homo-oligomers and the control of protein function.
Trevor Selwood, Eileen K Jaffe

Arch Biochem Biophys· March 2012

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Diverse clinical compounds alter the quaternary structure and inhibit the activity of an essential enzyme.
Sarah H Lawrence, Trevor Selwood, Eileen K Jaffe

ChemMedChem· June 2011

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Crystal structure of Toxoplasma gondii porphobilinogen synthase: insights on octameric structure and porphobilinogen formation.
Eileen K Jaffe, Dhanasekaran Shanmugam, Anna Gardberg, Shellie Dieterich, Banumathi Sankaran

J Biol Chem· April 2011

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Docking to large allosteric binding sites on protein surfaces.
Ursula D Ramirez, Faina Myachina, Linda Stith, Eileen K Jaffe

Adv Exp Med Biol· February 2011

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Plastid-associated porphobilinogen synthase from Toxoplasma gondii: kinetic and structural properties validate therapeutic potential.
Dhanasekaran Shanmugam, Bo Wu, Ursula Ramirez, Eileen K Jaffe, David S Roos

J Biol Chem· July 2010

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Pseudomonas aeruginosa porphobilinogen synthase assembly state regulators: hit discovery and initial SAR studies.
Allen B Reitz, Ursula D Ramirez, Linda Stith, Yanming Du, Garry R Smith, Eileen K Jaffe

ARKIVOC· June 2010

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MORPHEEINS - A NEW PATHWAY FOR ALLOSTERIC DRUG DISCOVERY.
Eileen K Jaffe

Open Conf Proc J· January 2010

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Allosteric inhibition of human porphobilinogen synthase.
Sarah H Lawrence, Ursula D Ramirez, Trevor Selwood, Linda Stith, Eileen K Jaffe

J Biol Chem· December 2009

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Probing the oligomeric assemblies of pea porphobilinogen synthase by analytical ultracentrifugation.
Bashkim Kokona, Daniel J Rigotti, Andrew S Wasson, Sarah H Lawrence, Eileen K Jaffe

Biochemistry· October 2008

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