Publications by authors named "Elena Dale"

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Preclinical evaluation of stereopure antisense oligonucleotides for allele-selective lowering of mutant .
Naoki Iwamoto, Yuanjing Liu, Maria Frank-Kamenetsky, Abbie Maguire, Wei Chou Tseng, Elena Dale

Mol Ther Nucleic Acids· September 2024

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Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists.
Christopher G Thomson, Kelly Boss, Amy Calhoun, Cary Fridrich, Kevin M Gardinier, Elena Dale

ACS Med Chem Lett· December 2023

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Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS.
Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam, Elena Dale

Nucleic Acids Res· June 2022

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Preclinical evaluation of WVE-004, aninvestigational stereopure oligonucleotide forthe treatment of -associated ALS or FTD.
Yuanjing Liu, Amy Andreucci, Naoki Iwamoto, Yuan Yin, Hailin Yang, Elena Dale

Mol Ther Nucleic Acids· June 2022

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Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.
Allen T Hopper, Martin Juhl, Jorrit Hornberg, Lassina Badolo, John Paul Kilburn, Elena Dale

J Med Chem· April 2021

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The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT receptor expressing interneurons: An in vitro study in rat hippocampus slices.
Elena Dale, Morten Grunnet, Alan L Pehrson, Kristen Frederiksen, Peter H Larsen

Brain Res· June 2018

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Impact of Vortioxetine on Synaptic Integration in Prefrontal-Subcortical Circuits: Comparisons with Escitalopram.
Shreaya Chakroborty, Thomas R Geisbush, Elena Dale, Alan L Pehrson, Connie Sánchez

Front Pharmacol· October 2017

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In vivo and in vitro effects of vortioxetine on molecules associated with neuroplasticity.
Pirathiv Kugathasan, Jessica Waller, Ligia Westrich, Aicha Abdourahman, Joseph A Tamm, Elena Dale

J Psychopharmacol· March 2017

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Inhibition of the potassium channel K3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury.
Roland G W Staal, Tanzilya Khayrullina, Hong Zhang, Scott Davis, Shaun M Fallon, Elena Dale

Eur J Pharmacol· January 2017

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Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review.
Kristian Gaarn du Jardin, Heidi Kaastrup Müller, Betina Elfving, Elena Dale, Gregers Wegener

Prog Neuropsychopharmacol Biol Psychiatry· November 2016

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KCa 3.1-a microglial target ready for drug repurposing?
Elena Dale, Roland G W Staal, Claudia Eder, Thomas Möller

Glia· October 2016

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Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.
Thomas Möller, Frédérique Bard, Anindya Bhattacharya, Knut Biber, Brian Campbell, Elena Dale

Glia· October 2016

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Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer's disease.
Peter Koppensteiner, Fabrizio Trinchese, Mauro Fà, Daniela Puzzo, Walter Gulisano, Elena Dale

Sci Rep· September 2016

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Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function.
Elena Dale, Alan L Pehrson, Theepica Jeyarajah, Yan Li, Steven C Leiser

CNS Spectr· April 2016

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A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression.
Yan Li, Alan L Pehrson, Jessica A Waller, Elena Dale, Connie Sanchez

Front Neurosci· August 2015

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Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine.
Steven C Leiser, Yan Li, Alan L Pehrson, Elena Dale, Gennady Smagin

ACS Chem Neurosci· July 2015

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Corrigendum: Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease.
Linda Lee, Elena Dale, Agnes Staniszewski, Hong Zhang, Faisal Saeed

Sci Rep· July 2015

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Chemical biology of mGlu4 receptor activation: dogmas, challenges, strategies and opportunities.
Xinyan Huang, Elena Dale, Robbin M Brodbeck, Dario Doller

Curr Top Med Chem· June 2015

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Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs.
Elena Dale, Benny Bang-Andersen, Connie Sánchez

Biochem Pharmacol· May 2015

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Treatment of cognitive dysfunction in major depressive disorder--a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine.
Alan L Pehrson, Steven C Leiser, Maria Gulinello, Elena Dale, Yan Li

Eur J Pharmacol· April 2015

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Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease.
Linda Lee, Elena Dale, Agnes Staniszewski, Hong Zhang, Faisal Saeed

Sci Rep· December 2014

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Distinct effects of mGlu4 receptor positive allosteric modulators at corticostriatal vs. striatopallidal synapses may differentially contribute to their antiparkinsonian action.
Paolo Gubellini, Christophe Melon, Elena Dale, Dario Doller, Lydia Kerkerian-Le Goff

Neuropharmacology· October 2014

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Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
Elena Dale, Hong Zhang, Steven C Leiser, Yixin Xiao, Dunguo Lu

J Psychopharmacol· October 2014

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