Publications by authors named "Steven C Leiser"

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Evaluation of variation in preclinical electroencephalographic (EEG) spectral power across multiple laboratories and experiments: An EQIPD study.
Tim P Ahuis, Magdalena K Smyk, Clément Laloux, Katharina Aulehner, Jack Bray, Steven C Leiser

PLoS One· October 2024

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Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex.
Lena H Nguyen, Steven C Leiser, Dekun Song, Daniela Brunner, Steven L Roberds

Epilepsy Res· March 2022

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Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex.
Wiebke Theilmann, Birthe Gericke, Alina Schidlitzki, Syed Muhammad Muneeb Anjum, Saskia Borsdorf, Steven C Leiser

Neuropharmacology· December 2020

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Aβ-accelerated neurodegeneration caused by Alzheimer's-associated variant R1279Q is rescued by angiotensin system inhibition in mice.
Leah K Cuddy, Dmitry Prokopenko, Eric P Cunningham, Ross Brimberry, Peter Song, Steven C Leiser

Sci Transl Med· September 2020

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Antisense oligonucleotides increase expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome.
Zhou Han, Chunling Chen, Anne Christiansen, Sophina Ji, Qian Lin, Steven C Leiser

Sci Transl Med· August 2020

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Acute dosing of vortioxetine strengthens event-related brain activity associated with engagement of attention and cognitive functioning in rats.
Bettina Laursen, Cecilie H Bundgaard, Carina Graversen, Morten Grupe, Connie Sanchez, Steven C Leiser

Brain Res· June 2017

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The 5-HT receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture.
Maria Amat-Foraster, Steven C Leiser, Kjartan F Herrik, Nelly Richard, Claus Agerskov

Neuropharmacology· February 2017

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Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function.
Elena Dale, Alan L Pehrson, Theepica Jeyarajah, Yan Li, Steven C Leiser

CNS Spectr· April 2016

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Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism.
Steven C Leiser, Deborah Iglesias-Bregna, Ligia Westrich, Alan L Pehrson, Connie Sanchez

J Psychopharmacol· October 2015

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Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine.
Steven C Leiser, Yan Li, Alan L Pehrson, Elena Dale, Gennady Smagin

ACS Chem Neurosci· July 2015

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Treatment of cognitive dysfunction in major depressive disorder--a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine.
Alan L Pehrson, Steven C Leiser, Maria Gulinello, Elena Dale, Yan Li

Eur J Pharmacol· April 2015

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Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
Elena Dale, Hong Zhang, Steven C Leiser, Yixin Xiao, Dunguo Lu

J Psychopharmacol· October 2014

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Can pharmaco-electroencephalography help improve survival of central nervous system drugs in early clinical development?
Frederick J Wilson, Steven C Leiser, Magnus Ivarsson, Søren R Christensen, Jesper F Bastlund

Drug Discov Today· March 2014

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Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials.
Robert E Featherstone, Jennifer M Phillips, Tony Thieu, Richard S Ehrlichman, Tobias B Halene, Steven C Leiser

PLoS One· April 2013

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Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease.
Brian F Corbett, Steven C Leiser, Huai-Ping Ling, Reka Nagy, Nathalie Breysse

J Neurosci· April 2013

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Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons.
Andre L Curtis, Steven C Leiser, Kevin Snyder, Rita J Valentino

Neuropharmacology· March 2012

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Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease.
Jon T Brown, Jeannie Chin, Steven C Leiser, Menelas N Pangalos, Andrew D Randall

Neurobiol Aging· November 2011

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Aligning strategies for using EEG as a surrogate biomarker: a review of preclinical and clinical research.
Steven C Leiser, John Dunlop, Mark R Bowlby, David M Devilbiss

Biochem Pharmacol· June 2011

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A cog in cognition: how the alpha 7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits.
Steven C Leiser, Mark R Bowlby, Thomas A Comery, John Dunlop

Pharmacol Ther· June 2009

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Impact of overactive bladder on the brain: central sequelae of a visceral pathology.
Elizabeth Rickenbacher, Madelyn A Baez, Lyman Hale, Steven C Leiser, Stephen A Zderic

Proc Natl Acad Sci U S A· July 2008

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Responses of trigeminal ganglion neurons during natural whisking behaviors in the awake rat.
Steven C Leiser, Karen A Moxon

Neuron· January 2007

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Impact of state of arousal and stress neuropeptides on urodynamic function in freely moving rats.
Darcie A Kiddoo, Rita J Valentino, Stephen Zderic, Arjunan Ganesh, Steven C Leiser

Am J Physiol Regul Integr Comp Physiol· June 2006

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Relationship between physiological response type (RA and SA) and vibrissal receptive field of neurons within the rat trigeminal ganglion.
Steven C Leiser, Karen A Moxon

J Neurophysiol· May 2006

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