Publications by authors named "Elisabeth Defossa"

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Molecular basis for inhibiting human glucose transporters by exofacial inhibitors.
Nan Wang, Shuo Zhang, Yafei Yuan, Hanwen Xu, Elisabeth Defossa

Nat Commun· May 2022

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Design, Synthesis, and Pharmacological Evaluation of Potent Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor (GLP-1R).
María Méndez, Hans Matter, Elisabeth Defossa, Michael Kurz, Sylvain Lebreton

J Med Chem· March 2020

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Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites.
Timothy Ackerson, Alexander Amberg, Jens Atzrodt, Catherine Arabeyre, Elisabeth Defossa

J Biochem Mol Toxicol· August 2019

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Recent developments in the discovery of FFA1 receptor agonists as novel oral treatment for type 2 diabetes mellitus.
Elisabeth Defossa, Michael Wagner

Bioorg Med Chem Lett· July 2014

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Drug design for G-protein-coupled receptors by a ligand-based NMR method.
Stefan Bartoschek, Thomas Klabunde, Elisabeth Defossa, Viktoria Dietrich, Siegfried Stengelin

Angew Chem Int Ed Engl· February 2010

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Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors.
Oliver Anderka, Petra Loenze, Thomas Klabunde, Matthias K Dreyer, Elisabeth Defossa

Biochemistry· April 2008

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Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes.
Thomas Klabunde, K Ulrich Wendt, Dieter Kadereit, Volker Brachvogel, Hans-Jörg Burger, Elisabeth Defossa

J Med Chem· October 2005

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Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs.
Nikos G Oikonomakos, Magda N Kosmopoulou, Evangelia D Chrysina, Demetres D Leonidas, Ioannis D Kostas, Elisabeth Defossa

Protein Sci· July 2005

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Design and quantitative structure-activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa.
Hans Matter, Elisabeth Defossa, Uwe Heinelt, Peter-Michael Blohm, Detlev Schneider

J Med Chem· June 2002

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