Publications by authors named "Elizabeth A Winzeler"

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Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum.
Henrico Langeveld, Keletso Maepa, Marché Maree, Jessica L Thibaud, Nicolaas Salomane, Elizabeth A Winzeler

Angew Chem Int Ed Engl· December 2025

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Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
Nobutaka Kato, Eamon Comer, Tomoyo Sakata-Kato, Arvind Sharma, Manmohan Sharma, Elizabeth A Winzeler

Nature· December 2025

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Mechanistic insights into dual-active liver and blood-stage antiplasmodials.
Mukul Rawat, Nonlawat Boonyalai, Cindy Smidt, Madeline R Luth, Daisy Chen, Elizabeth A Winzeler

mBio· November 2025

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Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in HSP90 Inhibitors.
Fu-Hsuan Ko, Amanda K Lukens, Mariana Laureano de Souza, Alex Foy, Jason Hsiao, Elizabeth A Winzeler

bioRxiv· November 2025

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Disruption of P. falciparum amino acid transporter elevates intracellular proline and induces resistance to Prolyl-tRNA synthetase inhibitors.
Selina Bopp, Lọla Fagbami, Amy Deik, Claudia Taccheri, Akansha Pant, Elizabeth A Winzeler

Cell Chem Biol· October 2025

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Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance.
John Okombo, Tolla Ndiaye, Tarrick Qahash, Igor M R Moura, Eva Gil-Iturbe, Elizabeth A Winzeler

Res Sq· October 2025

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Exploration of Fluorinated Peptoid-Based Histone Deacetylase Inhibitors as Dual-Stage Antiplasmodial Agents.
Nina Reßing, Daniel Stopper, Thomas Martin Schäfer, Lais Pessanha de Carvalho, Elizabeth A Winzeler

Arch Pharm (Weinheim)· August 2025

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Mechanistic Insights into Dual-Active Liver and Blood-Stage Antiplasmodials.
Mukul Rawat, Nonlawat Boonyalai, Cindy Smidt, Madeline R Luth, Daisy Chen, Elizabeth A Winzeler

bioRxiv· August 2025

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In vivo screen of Plasmodium targets for mosquito-based malaria control.
Alexandra S Probst, Douglas G Paton, Federico Appetecchia, Selina Bopp, Kelsey L Adams, Elizabeth A Winzeler

Nature· July 2025

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Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity.
Flore Nardella, Tiantian Jiang, Lushun Wang, Monica J Bohmer, Subhoja Chakraborty, Elizabeth A Winzeler

Cell Chem Biol· July 2025

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The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against via Dual Inhibition of Ark1 and Hemozoin Formation.
Kathryn J Wicht, John G Woodland, Larnelle F Garnie, Henrico Langeveld, Dale Taylor, Elizabeth A Winzeler

bioRxiv· July 2025

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Plasma Lipid Metabolites, Clinical Glycemic Predictors, and Incident Type 2 Diabetes.
Arjana Begzati, Karla P Godinez-Macias, Tao Long, Jeramie D Watrous, Rafael Moranchel, Elizabeth A Winzeler

Diabetes Care· March 2025

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Revisiting the druggable genome using predicted structures and data mining.
Karla P Godinez-Macias, Daisy Chen, J Lincoln Wallis, Miles G Siegel, Anna Adam, Elizabeth A Winzeler

NPJ Drug Discov· March 2025

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Fungal-derived methyldeoxaphomins target segregation through the inhibition of PfActin1.
Tiantian Jiang, Jin Woo Lee, Jennifer E Collins, Samuel Schaefer, Daisy Chen, Elizabeth A Winzeler

Proc Natl Acad Sci U S A· February 2025

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Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b.
Jon Kyle Awalt, Wenyin Su, William Nguyen, Katie Loi, Kate E Jarman, Elizabeth A Winzeler

Eur J Med Chem· December 2024

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Tambjamines as Fast-Acting Multistage Antimalarials.
Amrendra Kumar, Yuexin Li, Rozalia A Dodean, Alison Roth, Diana Caridha, Elizabeth A Winzeler

ACS Infect Dis· December 2024

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Transforming the Health Research Workforce in Mozambique: Achievements of the Mozambique Institute for Health Education and Research (MIHER) over a 13‑Year Journey.
Emília Virgínia Noormahomed, Sérgio Noormahomed, Matchecane Cossa, Nicole Joyce, Regina Daniel Miambo, Elizabeth A Winzeler

Ann Glob Health· December 2024

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Development of peptoid-based heteroaryl-decorated histone deacetylase (HDAC) inhibitors with dual-stage antiplasmodial activity.
Daniel Stopper, Lais Pessanha de Carvalho, Mariana Laureano de Souza, Cindy-Esther Kponomaizoun, Elizabeth A Winzeler

Eur J Med Chem· November 2024

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Author Correction: Antimalarial drug discovery: progress and approaches.
Jair L Siqueira-Neto, Kathryn J Wicht, Kelly Chibale, Jeremy N Burrows, David A Fidock, Elizabeth A Winzeler

Nat Rev Drug Discov· November 2024

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Systematic in vitro evolution in reveals key determinants of drug resistance.
Madeline R Luth, Karla P Godinez-Macias, Daisy Chen, John Okombo, Vandana Thathy, Elizabeth A Winzeler

Science· November 2024

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Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining.
Karla P Godinez-Macias, Daisy Chen, J Lincoln Wallis, Miles G Siegel, Anna Adam, Elizabeth A Winzeler

Res Sq· November 2024

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CACTI: an in silico chemical analysis tool through the integration of chemogenomic data and clustering analysis.
Karla P Godinez-Macias, Elizabeth A Winzeler

J Cheminform· July 2024

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Understanding the Antiplasmodial Action of Resistance-Refractory Xanthoquinodin A1.
Jennifer E Collins, Tiantian Jiang, Jin Woo Lee, Karen Wendt, Flore Nardella, Elizabeth A Winzeler

ACS Infect Dis· June 2024

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In vitro evolution and whole genome analysis to study chemotherapy drug resistance in haploid human cells.
Juan Carlos Jado, Michelle Dow, Krypton Carolino, Adam Klie, Gregory J Fonseca, Elizabeth A Winzeler

Sci Rep· June 2024

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Identification of fungal natural products with potent inhibition in .
Tiantian Jiang, Karla P Godinez-Macias, Jennifer E Collins, Jin Woo Lee, Karen L Wendt, Elizabeth A Winzeler

Microbiol Spectr· April 2024

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