Publications by authors named "Elizabeth Jaffee"

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A phase 2 trial of CXCR4 antagonism and PD1 inhibition in metastatic pancreatic adenocarcinoma reveals recruitment of T cells but also immunosuppressive macrophages.
Katherine M Bever, Sarah M Shin, Jennifer N Durham, Hanfei Qi, Alexei Hernandez, Elizabeth M Jaffee

Oncoimmunology· December 2025

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A therapeutic peptide vaccine for fibrolamellar hepatocellular carcinoma: a phase 1 trial.
Marina Baretti, Allison M Kirk, Brian H Ladle, Zeal Kamdar, Kayla J Bendinelli, Elizabeth Jaffee

Nat Med· December 2025

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Correction: Nivolumab and Relatlimab for the Treatment of Patients with Unresectable or Metastatic Mismatch Repair-Proficient Colorectal Cancer.
Eric S Christenson, Won Jin Ho, Daniel Shu, Jennifer N Durham, Madelena Brancati, Elizabeth M Jaffee

Clin Cancer Res· December 2025

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Neoadjuvant Immunotherapy Promotes the Formation of Mature Tertiary Lymphoid Structures in a Remodeled Pancreatic Tumor Microenvironment.
Dimitrios N Sidiropoulos, Sarah M Shin, Meredith Wetzel, Alexander A Girgis, Daniel Bergman, Elizabeth M Jaffee

Cancer Immunol Res· November 2025

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PASS-01: Randomized Phase II Trial of Modified FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel and Molecular Correlatives for Previously Untreated Metastatic Pancreatic Cancer.
Jennifer J Knox, Grainne O'Kane, Daniel King, Daniel Laheru, Amber N Habowski, Elizabeth M Jaffee

J Clin Oncol· November 2025

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BIWT: a bioinformatics walkthrough for embedding spatial multiomics in agent-based models for virtual cells.
Daniel R Bergman, Jeanette A I Johnson, Marwa Naji, Max Booth, Heber Lima da Rocha, Elizabeth M Jaffee

Bioinformatics· November 2025

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DNAJ-PKAc induces metabolic rewiring and enhanced glutamine flux in fibrolamellar HCC.
Zeal Kamdar, Ethan Neumann, Kathryn Howe, Donald Long, Waqar Arif, Elizabeth M Jaffee

J Hepatol· November 2025

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Comparative assessment of physiochemical metrics for the clustering of adaptive immune receptor repertoires.
Alexander A Girgis, Amanda L Huff, Emily Davis-Marcisak, Theron Palmer, Hanzhi Wang, Elizabeth M Jaffee

Nucleic Acids Res· November 2025

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Quantitative Calibration of a Spatial QSP Model Identifies Fibroblast Impact on HCC Immunotherapy.
Shuming Zhang, Hanwen Wang, Yeonju Cho, Wendy Wong, Mark Yarchoan, Elizabeth M Jaffee

bioRxiv· November 2025

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Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy.
Howard L Li, Soren Charmsaz, Mari Nakazawa, Stephanie L Alden, Madelena Brancati, Elizabeth M Jaffee

Cancer Res Commun· October 2025

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Erratum: PASS-01: Randomized Phase II Trial of Modified FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel and Molecular Correlatives for Previously Untreated Metastatic Pancreatic Cancer.
Jennifer J Knox, Grainne O'Kane, Daniel King, Daniel Laheru, Amber N Habowski, Elizabeth M Jaffee

J Clin Oncol· October 2025

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Nivolumab and Relatlimab for the Treatment of Patients with Unresectable or Metastatic Mismatch Repair-Proficient Colorectal Cancer.
Eric S Christenson, Won Jin Ho, Daniel Shu, Jennifer N Durham, Madelena Brancati, Elizabeth M Jaffee

Clin Cancer Res· August 2025

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A Phase II Study of Neoadjuvant GVAX and Cyclophosphamide Combined with Nivolumab and SBRT Followed by Surgery in Borderline Resectable Pancreatic Adenocarcinoma.
Parul Agarwal, Matthew Guo, Kabeer Munjal, Hanfei Qi, Rose Parkinson, Elizabeth M Jaffee

Clin Cancer Res· August 2025

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Spatial proteomics and transcriptomics reveal early immune cell organization in pancreatic intraepithelial neoplasia.
Melissa R Lyman, Jacob T Mitchell, Sidharth Raghavan, Luciane T Kagohara, Amanda L Huff, Elizabeth M Jaffee

JCI Insight· August 2025

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Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories.
Jeanette A I Johnson, Daniel R Bergman, Heber L Rocha, David L Zhou, Eric Cramer, Elizabeth M Jaffee

Cell· August 2025

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Recent advances in therapeutic cancer vaccines.
Neeha Zaidi, Elizabeth M Jaffee, Mark Yarchoan

Nat Rev Cancer· July 2025

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Anti-CTLA4 Therapy Leads to Early Expansion of a Peripheral Th17 Population and Induction of Th1 Cytokines.
Mari Nakazawa, Soren Charmsaz, Elsa Hallab, Mike Fang, Chester Kao, Elizabeth M Jaffee

Cancer Immunol Res· June 2025

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Modeling cellular influence delineates functionally relevant cellular neighborhoods in primary and metastatic pancreatic ductal adenocarcinoma.
Yeonju Cho, Jae W Lee, Sarah M Shin, Alexei G Hernandez, Xuan Yuan, Elizabeth M Jaffee

bioRxiv· June 2025

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Differential cell signaling testing for cell-cell communication inference from single-cell data by dominoSignal.
Jacob T Mitchell, Orian Stapleton, Kavita Krishnan, Sushma Nagaraj, Dmitrijs Lvovs, Elizabeth M Jaffee

bioRxiv· May 2025

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EphA2-targeted alpha-particle theranostics for enhancing PDAC treatment.
Ajay Kumar Sharma, Kuldeep Gupta, Akhilesh Mishra, Gabriela Lofland, Sophia Y Chen, Elizabeth M Jaffee

Theranostics· April 2025

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Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially control regulatory T cell phenotype and function via CXCL9 and CCL22.
Saumya Y Maru, Meredith Wetzel, Jacob T Mitchell, Nicole E Gross, Lalitya Andaloori, Elizabeth M Jaffee

bioRxiv· April 2025

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Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors.
Chester Kao, Soren Charmsaz, Hua-Ling Tsai, Khaled Aziz, Daniel H Shu, Elizabeth M Jaffee

Nat Commun· April 2025

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Immune-related events in individuals with solid tumors on immunotherapy associate with Th17 and Th2 signatures.
Chester J Kao, Soren Charmsaz, Stephanie L Alden, Madelena Brancati, Howard L Li, Elizabeth M Jaffee

J Clin Invest· March 2025

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Author Correction: Stromal changes in the aged lung induce an emergence from melanoma dormancy.
Mitchell E Fane, Yash Chhabra, Gretchen M Alicea, Devon A Maranto, Stephen M Douglass, Elizabeth M Jaffee

Nature· February 2025

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Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade.
Stephanie L Alden, Soren Charmsaz, Howard L Li, Hua-Ling Tsai, Ludmila Danilova, Elizabeth M Jaffee

J Immunother Cancer· January 2025

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