Publications by authors named "Elizabeth Parzych"

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Safety and pharmacokinetics of SARS-CoV-2 DNA-encoded monoclonal antibodies in healthy adults: a phase 1 trial.
Pablo Tebas, Ami Patel, Joseph T Agnes, Elizabeth M Parzych, Amanda Baer

Nat Med· December 2025

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Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa.
Jillian Eisenhauer, Spencer Dublin, Jihae Choi, Abigail R Trachtman, Jacqueline D Chu, Elizabeth M Parzych

Front Immunol· August 2025

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Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.
Nicholas J Tursi, Sachchidanand Tiwari, Nicole Bedanova, Toshitha Kannan, Elizabeth Parzych

Cell Rep Med· April 2025

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Structure and sequence engineering approaches to improve in vivo expression of nucleic acid-delivered antibodies.
Michaela Helble, Jacqueline Chu, Kaitlyn Flowers, Abigail R Trachtman, Alana Huynh, Elizabeth M Parzych

Mol Ther· January 2025

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In vivo delivery of engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis in non-human primates.
Ami Patel, Kyle Rosenke, Elizabeth M Parzych, Friederike Feldmann, Suman Bharti

Emerg Microbes Infect· December 2024

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Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity against ovarian cancers.
Devivasha Bordoloi, Abhijeet J Kulkarni, Opeyemi S Adeniji, M Betina Pampena, Pratik S Bhojnagarwala, Elizabeth M Parzych

Sci Adv· November 2023

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Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge.
Ebony N Gary, Nicholas J Tursi, Bryce M Warner, Gina Cuismano, Jennifer Connors, Elizabeth M Parzych

Front Immunol· April 2023

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DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2.
Elizabeth M Parzych, Jianqiu Du, Ali R Ali, Katherine Schultheis, Drew Frase

Nat Commun· October 2022

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Mucosal chemokine adjuvant enhances synDNA vaccine-mediated responses to SARS-CoV-2 and provides heterologous protection in vivo.
Ebony N Gary, Nicholas J Tursi, Bryce Warner, Elizabeth M Parzych, Ali R Ali

Cell Rep Med· July 2022

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Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates.
Jewell N Walters, Blake Schouest, Ami Patel, Emma L Reuschel, Katherine Schultheis, Elizabeth Parzych

Vaccine· May 2022

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Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model.
Ami Patel, Jewell N Walters, Emma L Reuschel, Katherine Schultheis, Elizabeth Parzych

Cell Rep Med· October 2021

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A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens.
Ebony N Gary, Bryce M Warner, Elizabeth M Parzych, Bryan D Griffin, Xizhou Zhu

iScience· July 2021

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Inclusion of an Optimized Merozoite Surface Protein 2-Based Antigen in a Trivalent, Multistage Malaria Vaccine.
Jacqueline S Eacret, Elizabeth M Parzych, Donna M Gonzales, James M Burns

J Immunol· April 2021

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Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection.
Elizabeth M Parzych, Sunita Gulati, Bo Zheng, Mamadou A Bah, Sarah T C Elliott

mBio· March 2021

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Nucleic acid approaches to antibody-based therapeutics for COVID-19: A perspective.
Elizabeth Parzych, David B Weiner

J Allergy Clin Immunol· September 2020

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Maintaining immunogenicity of blood stage and sexual stage subunit malaria vaccines when formulated in combination.
Elizabeth M Parzych, Kazutoyo Miura, Carole A Long, James M Burns

PLoS One· July 2020

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Evaluation of a Plasmodium-Specific Carrier Protein To Enhance Production of Recombinant s25, a Leading Transmission-Blocking Vaccine Candidate.
Elizabeth M Parzych, Kazutoyo Miura, Aarti Ramanathan, Carole A Long, James M Burns

Infect Immun· January 2018

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Age-related changes in the gene expression profile of antigen-specific mouse CD8+ T cells can be partially reversed by blockade of the BTLA/CD160 pathways during vaccination.
Noor Dawany, Elizabeth M Parzych, Louise C Showe, Hildegund Cj Ertl

Aging (Albany NY)· November 2016

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Effects of immunosuppression on circulating adeno-associated virus capsid-specific T cells in humans.
Elizabeth M Parzych, Hua Li, Xiangfan Yin, Qin Liu, Te-Lang Wu

Hum Gene Ther· April 2013

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Vaccine-induced T cells provide partial protection against high-dose rectal SIVmac239 challenge of rhesus macaques.
Marcio O Lasaro, Larissa H Haut, Xiangyang Zhou, Zhiquan Xiang, Dongming Zhou, Elizabeth M Parzych

Mol Ther· February 2011

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A universal influenza A vaccine based on adenovirus expressing matrix-2 ectodomain and nucleoprotein protects mice from lethal challenge.
Dongming Zhou, Te-Lang Wu, Marcio O Lasaro, Brian P Latimer, Elizabeth M Parzych

Mol Ther· December 2010

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Augmentation of primary influenza A virus-specific CD8+ T cell responses in aged mice through blockade of an immunoinhibitory pathway.
Lauren DiMenna, Brian Latimer, Elizabeth Parzych, Larissa H Haut, Katrin Töpfer

J Immunol· May 2010

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