Publications by authors named "David B Weiner"

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Safety and pharmacokinetics of SARS-CoV-2 DNA-encoded monoclonal antibodies in healthy adults: a phase 1 trial.
Pablo Tebas, Ami Patel, Joseph T Agnes, Elizabeth M Parzych, Amanda Baer, David B Weiner

Nat Med· December 2025

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Siglecs in immunotherapy: current clinical landscape and prospects.
Abhinav Purohit, Ishaan Joshi, Pratik S Bhojnagarwala, Jean D Boyer, J Joseph Kim, David B Weiner

Trends Pharmacol Sci· December 2025

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Synthetic DNA co-immunization with vaccine-aligned common consensus nucleoprotein and hemagglutinin protects mice against lethal influenza infection with a single immunization.
Ebony N Gary, Abigail R Trachtman, Dan Wang, Suman Bharti, Ying Ye, David B Weiner

Front Immunol· December 2025

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Novel enzymatic DNA produced from a text file achieves comparable immune responses as plasmid vaccine.
James Fuller, Erik Kvam, Sandrine Creton, Courtney Hall, Nicholas J Tursi, David B Weiner

NPJ Vaccines· December 2025

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Targeting LxCxE Cleft Pocket of Retinoblastoma Protein in Immunosuppressive Macrophages Inhibits Ovarian Cancer Progression.
Evgenii N Tcyganov, Taekyoung Kwak, Xue Yang, Adi Narayana Reddy Poli, Colin Hart, David B Weiner

Cancer Immunol Res· November 2025

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Electroporation and LNP-mediated delivery of plasmid DNA-encoded H5N1 influenza virus hemagglutinin support protection against highly pathogenic avian influenza.
Ebony N Gary, Nicholas J Tursi, Casey E Hojecki, Robert Vendramelli, Martina Tomirotti, David B Weiner

NPJ Vaccines· November 2025

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Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination.
Rumi Habib, Shahlo O Solieva, Zi Jie Lin, Sukanya Ghosh, Kelly Bayruns, David B Weiner

bioRxiv· November 2025

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Advances in molecular adjuvants for nucleic acid vaccines.
Casey E Hojecki, Nicholas J Tursi, Cory Livingston, David B Weiner, Ebony N Gary

Front Immunol· October 2025

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Notch2 signaling instructs viral and bacterial TLR responsiveness in B cells.
Jennifer Londregan, Isaiah Rozich, Brian T Gaudette, Nicholas J Tursi, David B Weiner

bioRxiv· October 2025

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Rapid elicitation of a new class of neutralizing N332-glycan independent V3-glycan antibodies against HIV-1 in nonhuman primates.
Ignacio Relano-Rodriguez, Jianqiu Du, Zi Jie Lin, Margaret Kerwin, Marta Tarquis-Medina, David B Weiner

bioRxiv· September 2025

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Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa.
Jillian Eisenhauer, Spencer Dublin, Jihae Choi, Abigail R Trachtman, Jacqueline D Chu, David B Weiner

Front Immunol· August 2025

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DNA-based immunotherapy for cancer: In vivo approaches for recalcitrant targets.
Pratik S Bhojnagarwala, Joshua Jose, Shushu Zhao, David B Weiner

Mol Ther· June 2025

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DNA co-delivery of seasonal H1 influenza hemagglutinin nanoparticle vaccines with chemokine adjuvant CTACK induces potent immunogenicity for heterologous protection in vivo.
Kevin Liaw, Kylie M Konrath, Abigail R Trachtman, Nicholas J Tursi, Ebony N Gary, David B Weiner

Vaccine· June 2025

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Targeting IL13Rα2 in melanoma with a bispecific T-cell engager: expression profiling and preclinical evaluation.
Shushu Zhao, Yeqing Chen, Pratik S Bhojnagarwala, Cory Livingston, Joshua Jose, David B Weiner

J Immunother Cancer· June 2025

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Structural engineering of stabilized, expanded epitope nanoparticle vaccines for HPV.
Michaela Helble, Xizhou Zhu, Pratik S Bhojnagarwala, Kevin Liaw, Yangcheng Gao, David B Weiner

Front Immunol· May 2025

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Convergence and divergence of B cell responses in two HIV-1 Env immunizations in Rhesus macaques.
Jenna M DeLuca, Maria Blasi, Taylor J McGee, Shalini Jha, Xiaoying Shen, David B Weiner

Commun Med (Lond)· May 2025

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Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.
Nicholas J Tursi, Sachchidanand Tiwari, Nicole Bedanova, Toshitha Kannan, Elizabeth Parzych, David B Weiner

Cell Rep Med· April 2025

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DNA immunotherapy for recurrent respiratory papillomatosis (RRP): phase 1/2 study assessing efficacy, safety, and immunogenicity of INO-3107.
Matthew P Morrow, Elisabeth Gillespie, Albert Sylvester, Milan R Amin, Peter C Belafsky, David B Weiner

Nat Commun· February 2025

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Structure and sequence engineering approaches to improve in vivo expression of nucleic acid-delivered antibodies.
Michaela Helble, Jacqueline Chu, Kaitlyn Flowers, Abigail R Trachtman, Alana Huynh, David B Weiner

Mol Ther· January 2025

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Safety and immunogenicity of an optimized self-replicating RNA platform for low dose or single dose vaccine applications: a randomized, open label Phase I study in healthy volunteers.
Christian J Maine, Shigeki J Miyake-Stoner, Darina S Spasova, Gaelle Picarda, Annie C Chou, David B Weiner

Nat Commun· January 2025

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In vivo delivery of engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis in non-human primates.
Ami Patel, Kyle Rosenke, Elizabeth M Parzych, Friederike Feldmann, Suman Bharti, David B Weiner

Emerg Microbes Infect· December 2024

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Novel tri-specific T-cell engager targeting IL-13Rα2 and EGFRvIII provides long-term survival in heterogeneous GBM challenge and promotes antitumor cytotoxicity with patient immune cells.
Daniel H Park, Pratik S Bhojnagarwala, Kevin Liaw, Devivasha Bordoloi, Nicholas J Tursi, David B Weiner

J Immunother Cancer· December 2024

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Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial.
Mark Yarchoan, Edward J Gane, Thomas U Marron, Renzo Perales-Linares, Jian Yan, David B Weiner

Nat Med· April 2024

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B cell immunofocusing and repriming in two HIV-1 Env immunization regimens.
Jenna M DeLuca, Maria Blasi, Shalini Jha, Xiaoying Shen, Justin Pollara, David B Weiner

Res Sq· April 2024

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Modified messenger-RNA components alter the encoded protein.
Nicholas J Tursi, David B Weiner

Nature· January 2024

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