Publications by authors named "Elke Valk"

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Pre-phase treatment with rituximab and high-dose methotrexate to re-evaluate eligibility for intensive induction treatment of frail patients with central nervous system lymphoma.
Julia Wendler, Richard I Lewis, Alexandra Kutilina, Markus Knott, Lisa Kristina Isbell, Elke Valk

Haematologica· June 2025

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Age-adjusted high-dose chemotherapy followed by autologous stem cell transplantation or conventional chemotherapy with R-MP as first-line treatment in elderly primary CNS lymphoma patients - the randomized phase III PRIMA-CNS trial.
Lisa K Isbell, Roswitha Uibeleisen, Alexander Friedl, Elvira Burger, Tatja Dopatka, Elke Valk

BMC Cancer· August 2023

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Optimizing MATRix as remission induction in PCNSL: de-escalated induction treatment in newly diagnosed primary CNS lymphoma.
Julia Wendler, Christopher P Fox, Elke Valk, Cora Steinheber, Heidi Fricker

BMC Cancer· September 2022

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High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial.
Gerald Illerhaus, Benjamin Kasenda, Gabriele Ihorst, Gerlinde Egerer, Monika Lamprecht, Elke Valk

Lancet Haematol· August 2016

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High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma--a randomized phase III trial (MATRix).
Elisabeth Schorb, Juergen Finke, Andrés J M Ferreri, Gabriele Ihorst, Kristina Mikesch, Elke Valk

BMC Cancer· April 2016

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Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression.
Matthew C Banton, Kerry L Inder, Elke Valk, Christopher E Rudd, Helga Schneider

Mol Cell Biol· April 2014

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CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death.
Helga Schneider, Elke Valk, Rufina Leung, Christopher E Rudd

PLoS One· February 2009

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CTLA-4 trafficking and surface expression.
Elke Valk, Christopher E Rudd, Helga Schneider

Trends Immunol· June 2008

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Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.
Helga Schneider, Hongyan Wang, Monika Raab, Elke Valk, Xin Smith

PLoS One· March 2008

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T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor.
Elke Valk, Rufina Leung, Hyun Kang, Kazuyo Kaneko, Christopher E Rudd

Immunity· November 2006

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CTLA-4 regulation of T cell function via RAP-1-mediated adhesion.
Helga Schneider, Elke Valk, Silvy da Rocha Dias, Bin Wei, Christopher E Rudd

Adv Exp Med Biol· October 2006

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CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function.
Helga Schneider, Elke Valk, Silvy da Rocha Dias, Bin Wei, Christopher E Rudd

Proc Natl Acad Sci U S A· September 2005

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Thiol antioxidants block the activation of antigen-presenting cells by contact sensitizers.
Stefanie Bruchhausen, Sabine Zahn, Elke Valk, Jürgen Knop, Detlef Becker

J Invest Dermatol· November 2003

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Coupling of contact sensitizers to thiol groups is a key event for the activation of monocytes and monocyte-derived dendritic cells.
Detlef Becker, Elke Valk, Sabine Zahn, Pia Brand, Jürgen Knop

J Invest Dermatol· February 2003

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JAK/STAT pathways are not involved in the direct activation of antigen-presenting cells by contact sensitizers.
Elke Valk, Sabine Zahn, Jürgen Knop, Detlef Becker

Arch Dermatol Res· July 2002

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Activation and translocation of p38 mitogen-activated protein kinase after stimulation of monocytes with contact sensitizers.
Pia Brand, Sibylle Plochmann, Elke Valk, Sabine Zahn, Joachim Saloga

J Invest Dermatol· July 2002

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