Publications by authors named "Ellen A Cannady"

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Prediction of Transporter-Mediated Drug-Drug Interactions for Baricitinib.
Maria M Posada, Ellen A Cannady, Christopher D Payne, Xin Zhang, James A Bacon

Clin Transl Sci· November 2017

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Fertility and Embryo-Fetal Development Assessment in Rats and Rabbits with Evacetrapib: A Cholesteryl Ester Transfer Protein Inhibitor.
William J Breslin, Kim G Hilbish, Ellen A Cannady, Tammy L Edwards

Birth Defects Res· April 2017

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Prenatal and Postnatal Assessment in Rabbits with Evacetrapib: A Cholesteryl Ester Transfer Protein Inhibitor.
William J Breslin, Kim G Hilbish, Ellen A Cannady, Tammy L Edwards

Birth Defects Res· April 2017

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The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470).
Chafiq Hamdouchi, Steven D Kahl, Anjana Patel Lewis, Guemalli R Cardona, Richard W Zink, Ellen A Cannady

J Med Chem· December 2016

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Impact of Increased Gastric pH on the Pharmacokinetics of Evacetrapib in Healthy Subjects.
David S Small, Jane Royalty, Ellen A Cannady, Christine Hale, Ming-Dauh Wang

Pharmacotherapy· July 2016

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Absolute bioavailability of evacetrapib in healthy subjects determined by simultaneous administration of oral evacetrapib and intravenous [(13) C8 ]-evacetrapib as a tracer.
Ellen A Cannady, Aktham Aburub, Chris Ward, Chris Hinds, Boris Czeskis

J Labelled Comp Radiopharm· May 2016

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Effect of hepatic or renal impairment on the pharmacokinetics of evacetrapib.
David S Small, Wei Zhang, Jane Royalty, Ellen A Cannady, Delyn Downs

Eur J Clin Pharmacol· May 2016

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CYP-mediated drug-drug interactions with evacetrapib, an investigational CETP inhibitor: in vitro prediction and clinical outcome.
Ellen A Cannady, Jeffrey G Suico, Ming-Dauh Wang, Stuart Friedrich, Jessica R F Rehmel

Br J Clin Pharmacol· December 2015

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Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia.
Michael J Genin, Ana B Bueno, Javier Agejas Francisco, Peter R Manninen, Wayne P Bocchinfuso, Ellen A Cannady

J Med Chem· December 2015

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Evacetrapib: in vitro and clinical disposition, metabolism, excretion, and assessment of drug interaction potential with strong CYP3A and CYP2C8 inhibitors.
Ellen A Cannady, Ming-Dauh Wang, Stuart Friedrich, Jessica L F Rehmel, Ping Yi

Pharmacol Res Perspect· October 2015

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A Multidose Study to Examine the Effect of Food on Evacetrapib Exposure at Steady State.
David S Small, Wei Zhang, Jane Royalty, Ellen A Cannady, Delyn Downs

J Cardiovasc Pharmacol Ther· September 2015

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Effects of the cholesteryl ester transfer protein inhibitor evacetrapib on lipoproteins, apolipoproteins and 24-h ambulatory blood pressure in healthy adults.
Jeffrey G Suico, Ming-Dauh Wang, Stuart Friedrich, Ellen A Cannady, Christopher S Konkoy

J Pharm Pharmacol· November 2014

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Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors.
Ana Escribano, Ana I Mateo, Eva M Martin de la Nava, Daniel R Mayhugh, Sandra L Cockerham, Ellen A Cannady

Bioorg Med Chem Lett· June 2012

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Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors.
Maria-Carmen Fernandez, Ana Escribano, Ana I Mateo, Saravanan Parthasarathy, Eva M Martin de la Nava, Ellen A Cannady

Bioorg Med Chem Lett· May 2012

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Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure.
Guoqing Cao, Thomas P Beyer, Youyan Zhang, Robert J Schmidt, Yan Q Chen, Ellen A Cannady

J Lipid Res· December 2011

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Involvement of CYP 2E1 enzyme in ovotoxicity caused by 4-vinylcyclohexene and its metabolites.
Kathila S Rajapaksa, Ellen A Cannady, I Glenn Sipes, Patricia B Hoyer

Toxicol Appl Pharmacol· June 2007

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Expression and activity of cytochromes P450 2E1, 2A, and 2B in the mouse ovary: the effect of 4-vinylcyclohexene and its diepoxide metabolite.
Ellen A Cannady, Cheryl A Dyer, Patricia J Christian, I Glenn Sipes, Patricia B Hoyer

Toxicol Sci· June 2003

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Expression and activity of microsomal epoxide hydrolase in follicles isolated from mouse ovaries.
Ellen A Cannady, Cheryl A Dyer, Patricia J Christian, I Glenn Sipes, Patricia B Hoyer

Toxicol Sci· July 2002

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