Publications by authors named "Elliot Goodfellow"

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The PLK4 inhibitor RP-1664 demonstrates potent single-agent efficacy in neuroblastoma models through a dual mechanism of sensitivity.
John Maris, Isabel Soria-Bretones, Matias Casás-Selves, Minu Samanta, David Groff, Elliot Goodfellow Goodfellow

Res Sq· July 2025

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Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor.
Frédéric Vallée, Matias Casás-Selves, Monica Bubenik, Martin Duplessis, Boubacar Sow, Elliot Goodfellow

J Med Chem· June 2025

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MICAL2 Promotes Pancreatic Cancer Growth and Metastasis.
Bharti Garg, Sohini Khan, Asimina S Courelli, Ponmathi Panneerpandian, Deepa Sheik Pran Babu, Elliot Goodfellow

Cancer Res· March 2025

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MICAL2 Is a Super Enhancer Associated Gene that Promotes Pancreatic Cancer Growth and Metastasis.
Bharti Garg, Sohini Khan, Deepa Sheikh Babu, Evangeline Mose, Kevin Gulay, Elliot Goodfellow

bioRxiv· June 2024

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Design and Synthesis of a Trifunctional Molecular System "Programmed" to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-ribose) Polymerase) in Prostate Cancer Cells.
Julie Schmitt, Shanlong Huang, Elliot Goodfellow, Christopher Williams, Bertrand J Jean-Claude

J Med Chem· June 2020

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Comparative analysis of the dual EGFR-DNA targeting and growth inhibitory properties of 6-mono-alkylamino- and 6,6-dialkylaminoquinazoline-based type II combi-molecules.
Julie Schmitt, Elliot Goodfellow, Shanlong Huang, Christopher Williams, Izabela N F Gomes

Eur J Med Chem· April 2020

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A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells.
Zhor Senhaji Mouhri, Elliot Goodfellow, Bertrand Jean-Claude

BMC Cancer· August 2017

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N-, C- and ¹H-NMR Spectroscopy Characterization and Growth Inhibitory Potency of a Combi-Molecule Synthesized by Acetylation of an Unstable Monoalkyltriazene.
Zhor Senhaji Mouhri, Elliot Goodfellow, Steven P Kelley, Robin S Stein, Robin D Rogers

Molecules· July 2017

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Design, synthesis and biological activity of novel molecules designed to target PARP and DNA.
Elliot Goodfellow, Zhor Senhaji Mouhri, Christopher Williams, Bertrand J Jean-Claude

Bioorg Med Chem Lett· February 2017

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