Publications by authors named "Elliot Offman"

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Physiologically Based Pharmacokinetic Modeling and Simulation to Support a Change in the FDA-Labeled Dosing Frequency of RHB-105 Low-Dose Rifabutin Triple Therapy for Helicobacter pylori Eradication.
Nimish Vakil, Colin W Howden, Shailja C Shah, Kuan-Fu Chen, Elliot Offman

J Clin Pharmacol· June 2025

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First-in-human phase I trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein, SL-172154 in patients with platinum-resistant ovarian cancer.
Nehal J Lakhani, Daphne Stewart, Debra L Richardson, Lauren E Dockery, Linda Van Le, Elliot Offman

J Immunother Cancer· January 2025

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Triple-Antibiotic Combination Exerts Effective Activity against subsp. Biofilm and Airway Infection in an In Vivo Murine Model.
Elliot M Offman, Amy Leestemaker-Palmer, Reza Fathi, Bailey Keefe, Aida Bibliowicz

Antibiotics (Basel)· May 2024

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The Novel GlycoPEGylated FGF21 Analog Pegozafermin Activates Human FGF Receptors and Improves Metabolic and Liver Outcomes in Diabetic Monkeys and Healthy Human Volunteers.
Moti Rosenstock, Leo Tseng, Andrew Pierce, Elliot Offman, Chao-Yin Chen

J Pharmacol Exp Ther· November 2023

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Physiologically-based pharmacokinetic modelling to predict intragastric rifabutin concentrations in the treatment of Helicobacter pylori infection.
Colin W Howden, Shailja Shah, Salil N Pendse, Elliot Offman, June S Almenoff

Aliment Pharmacol Ther· July 2023

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Leveraging and pharmacokinetic models to support bench to bedside investigation of XTMAB-16 as a novel pulmonary sarcoidosis treatment.
Elliot Offman, Noopur Singh, Mark W Julian, Landon W Locke, Sabahattin Bicer

Front Pharmacol· March 2023

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Population Pharmacokinetics of Brigatinib in Healthy Volunteers and Patients With Cancer.
Neeraj Gupta, Xiaohui Wang, Elliot Offman, Marita Prohn, Narayana Narasimhan

Clin Pharmacokinet· February 2021

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Brigatinib Dose Rationale in Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer: Exposure-Response Analyses of Pivotal ALTA Study.
Neeraj Gupta, Xiaohui Wang, Elliot Offman, Benjamin Rich, David Kerstein

CPT Pharmacometrics Syst Pharmacol· December 2020

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A Randomized Comparison of the Pharmacokinetics and Bioavailability of Fluticasone Propionate Delivered via Xhance Exhalation Delivery System Versus Flonase Nasal Spray and Flovent HFA Inhalational Aerosol.
John C Messina, Elliot Offman, Jennifer L Carothers, Ramy A Mahmoud

Clin Ther· November 2019

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Assessment of pharmacokinetic interaction between omega-3 carboxylic acids and the statins rosuvastatin and simvastatin: Results of 2 phase I studies in healthy volunteers.
Elliot Offman, Michael Davidson, Catarina Nilsson

J Clin Lipidol· December 2017

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Systemic Bioavailability and Dose Proportionality of Omega-3 Administered in Free Fatty Acid Form Compared With Ethyl Ester Form: Results of a Phase 1 Study in Healthy Volunteers.
Elliot Offman, Michael Davidson, Mohammad Abu-Rashid, Peng Chai, Catarina Nilsson

Eur J Drug Metab Pharmacokinet· October 2017

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Evaluation of the Potential for Drug Interactions With Patiromer in Healthy Volunteers.
Lawrence J Lesko, Elliot Offman, Christine Taylor Brew, Dahlia Garza, Wade Benton

J Cardiovasc Pharmacol Ther· September 2017

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No Effect of Omega-3 Carboxylic Acids on Pharmacokinetics/Pharmacodynamics of Warfarin or on Platelet Function When Co-administered with Acetylsalicylic Acid: Results of Two Phase I Studies in Healthy Volunteers.
Elliot Offman, Michael Davidson, Catarina Nilsson

Am J Cardiovasc Drugs· June 2017

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A Novel NF-κB Inhibitor, Edasalonexent (CAT-1004), in Development as a Disease-Modifying Treatment for Patients With Duchenne Muscular Dystrophy: Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics in Adult Subjects.
Joanne M Donovan, Michael Zimmer, Elliot Offman, Toni Grant, Michael Jirousek

J Clin Pharmacol· May 2017

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Update and trends on pharmacokinetic studies in patients with impaired renal function: practical insight into application of the FDA and EMA guidelines.
Sabina Paglialunga, Elliot Offman, Nita Ichhpurani, Thomas C Marbury, Bruce H Morimoto

Expert Rev Clin Pharmacol· March 2017

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Pharmacokinetic Time Course Scaling of a Subcutaneously Administered Pegylated Peptide Conjugate for a First-in-Human Investigation.
Elliot Offman, Andrea N Edginton

Eur J Drug Metab Pharmacokinet· February 2017

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Population physiologically-based pharmacokinetic model incorporating lymphatic uptake for a subcutaneously administered pegylated peptide.
Elliot Offman, Colin Phipps, Andrea N Edginton

In Silico Pharmacol· December 2016

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A Randomized Trial Comparing the Pharmacokinetics, Safety, and Tolerability of DFN-02, an Intranasal Sumatriptan Spray Containing a Permeation Enhancer, With Intranasal and Subcutaneous Sumatriptan in Healthy Adults.
Sagar Munjal, Anirudh Gautam, Elliot Offman, Elimor Brand-Schieber, Kent Allenby

Headache· October 2016

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Pharmacokinetics of cabozantinib tablet and capsule formulations in healthy adults.
Linh Nguyen, Natacha Benrimoh, Yuli Xie, Elliot Offman, Steven Lacy

Anticancer Drugs· August 2016

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A PBPK workflow for first-in-human dose selection of a subcutaneously administered pegylated peptide.
Elliot Offman, Andrea N Edginton

J Pharmacokinet Pharmacodyn· April 2015

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Steady-state bioavailability of prescription omega-3 on a low-fat diet is significantly improved with a free fatty acid formulation compared with an ethyl ester formulation: the ECLIPSE II study.
Elliot Offman, Ted Marenco, Sandy Ferber, Judith Johnson, Douglas Kling

Vasc Health Risk Manag· March 2014

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Improved pharmacokinetics of sumatriptan with Breath Powered™ nasal delivery of sumatriptan powder.
Mohammad Obaidi, Elliot Offman, John Messina, Jennifer Carothers, Per G Djupesland

Headache· September 2013

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Contrasting toxicokinetic evaluations and interspecies pharmacokinetic scaling approaches for small molecules and biologics: applicability to biosimilar development.
Elliot Offman, Andrea N Edginton

Xenobiotica· June 2013

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Pharmacokinetics and pharmacodynamics of the antiplatelet combination aspirin (acetylsalicylic acid) plus extended-release dipyridamole are not altered by coadministration with the potent CYP2C19 inhibitor omeprazole.
Elliot Offman, Michael J Schobelock, Rolf Brickl, Cam P VanderMaelen, Jerome Ehrlich

Am J Cardiovasc Drugs· April 2013

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Formation of a Global Contract Research Organization Council for Bioanalysis.
Noel Premkumar, Stephen Lowes, James Jersey, Fabio Garofolo, Isabelle Dumont, Elliot Offman

Bioanalysis· November 2010

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