Publications by authors named "Emiko Mihara"

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Muscle-specific tyrosine kinase activation by a peptide-based dimerizer is orientation dependent.
Fumiya Mizutani, Kyoko Matoba, Hayden Peacock, Mitsuhiro Yamada, Emiko Mihara

Structure· November 2025

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Impact of mechanotransduction on gene expression changes in periodontal ligament during orthodontic tooth movement.
Suzu Chida, Tomoki Chiba, Yutaro Uchida, Takahide Matsushima, Ryota Kurimoto, Emiko Mihara

J Bone Miner Metab· May 2025

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PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination.
Giulia Franzolin, Serena Brundu, Carina F Cojocaru, Aurora Curatolo, Matteo Ponzo, Emiko Mihara

Cancer Immunol Res· September 2024

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A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model.
Nichole Marcela Rojas-Chaverra, Ryu Imamura, Hiroki Sato, Toby Passioura, Emiko Mihara

iScience· August 2024

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Locally misfolded HER2 expressed on cancer cells is a promising target for development of cancer-specific antibodies.
Takao Arimori, Emiko Mihara, Hiroyuki Suzuki, Tomokazu Ohishi, Tomohiro Tanaka

Structure· May 2024

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Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions.
Katsuya Sakai, Nozomi Sugano-Nakamura, Emiko Mihara, Nichole Marcela Rojas-Chaverra, Sayako Watanabe

Nat Biomed Eng· February 2023

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Hybrid in vitro/in silico analysis of low-affinity protein-protein interactions that regulate signal transduction by Sema6D.
Tsubasa Tanaka, Toru Ekimoto, Meri Nagatomo, Makiko Neyazaki, Erena Shimoji, Emiko Mihara

Protein Sci· November 2022

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Functional role of the Frizzled linker domain in the Wnt signaling pathway.
Seung-Bum Ko, Emiko Mihara, Yedarm Park, Kyeonghwan Roh, Chanhee Kang

Commun Biol· May 2022

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Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.
Kana Hasegawa, Shunya Ikeda, Moto Yaga, Kouki Watanabe, Rika Urakawa, Emiko Mihara

Sci Transl Med· February 2022

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De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist.
Yamato Komatsu, Naohiro Terasaka, Katsuya Sakai, Emiko Mihara, Risa Wakabayashi

iScience· November 2021

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Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2.
Yusuke Higuchi, Tatsuya Suzuki, Takao Arimori, Nariko Ikemura, Emiko Mihara

Nat Commun· June 2021

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Structural mechanism of laminin recognition by integrin.
Takao Arimori, Naoyuki Miyazaki, Emiko Mihara, Mamoru Takizawa, Yukimasa Taniguchi

Nat Commun· June 2021

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Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins.
Emiko Mihara, Satoshi Watanabe, Nasir K Bashiruddin, Nozomi Nakamura, Kyoko Matoba

Nat Commun· March 2021

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Macrocyclic peptides that inhibit Wnt signalling interaction with Wnt3a.
Manuel E Otero-Ramirez, Kyoko Matoba, Emiko Mihara, Toby Passioura, Junichi Takagi

RSC Chem Biol· April 2020

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Crystal structure of a mammalian Wnt-frizzled complex.
Hidenori Hirai, Kyoko Matoba, Emiko Mihara, Takao Arimori, Junichi Takagi

Nat Struct Mol Biol· May 2019

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Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V.
Masamichi Nagae, Yasuhiko Kizuka, Emiko Mihara, Yu Kitago, Shinya Hanashima

Nat Commun· August 2018

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An anti-peptide monoclonal antibody recognizing the tobacco etch virus protease-cleavage sequence and its application to a tandem tagging system.
Sanae Tabata, Yu Kitago, Yuki Fujii, Emiko Mihara, Keiko Tamura-Kawakami

Protein Expr Purif· July 2018

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Immunoaffinity Purification of the Glycosylated Extracellular Fragment of Mouse Plexin A2 Produced in a Mammalian Expression System.
Terukazu Nogi, Emiko Mihara, Norihisa Yasui, Junichi Takagi

Methods Mol Biol· February 2018

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Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation.
Kyoko Shirakabe, Takuya Omura, Yoshio Shibagaki, Emiko Mihara, Keiichi Homma

Sci Rep· April 2017

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Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1.
Kyoko Matoba, Emiko Mihara, Keiko Tamura-Kawakami, Naoyuki Miyazaki, Shintaro Maeda

Cell Rep· January 2017

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Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase.
Junko Morita, Kuniyuki Kano, Kazuki Kato, Hiroyuki Takita, Hideki Sakagami, Emiko Mihara

Sci Rep· February 2016

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Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.
Emiko Mihara, Hidenori Hirai, Hideki Yamamoto, Keiko Tamura-Kawakami, Mami Matano

Elife· February 2016

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Structural basis for amyloidogenic peptide recognition by sorLA.
Yu Kitago, Masamichi Nagae, Zenzaburo Nakata, Maho Yagi-Utsumi, Shizuka Takagi-Niidome, Emiko Mihara

Nat Struct Mol Biol· March 2015

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Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp6.
Junko Morita, Kazuki Kato, Emiko Mihara, Ryuichiro Ishitani, Junichi Takagi

Acta Crystallogr F Struct Biol Commun· June 2014

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Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Kazuki Kato, Hiroshi Nishimasu, Shinichi Okudaira, Emiko Mihara, Ryuichiro Ishitani

Proc Natl Acad Sci U S A· October 2012

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