Publications by authors named "Ryu Imamura"

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A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model.
Nichole Marcela Rojas-Chaverra, Ryu Imamura, Hiroki Sato, Toby Passioura, Emiko Mihara

iScience· August 2024

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Met receptor is essential for MAVS-mediated antiviral innate immunity in epithelial cells independent of its kinase activity.
Ryu Imamura, Hiroki Sato, Dominic Chih-Cheng Voon, Takayoshi Shirasaki, Masao Honda

Proc Natl Acad Sci U S A· October 2023

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Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions.
Katsuya Sakai, Nozomi Sugano-Nakamura, Emiko Mihara, Nichole Marcela Rojas-Chaverra, Sayako Watanabe, Ryu Imamura

Nat Biomed Eng· February 2023

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A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration.
Naoya Hino, Kimiya Matsuda, Yuya Jikko, Gembu Maryu, Katsuya Sakai, Ryu Imamura

Dev Cell· October 2022

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Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET.
Takayoshi Shirasaki, Satoshi Yamagoe, Tetsuro Shimakami, Kazuhisa Murai, Ryu Imamura

Nat Commun· June 2022

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Dimer Interface in Natural Variant NK1 Is Dispensable for HGF-Dependent Met Receptor Activation.
Yumiko Tahira, Katsuya Sakai, Hiroki Sato, Ryu Imamura, Kunio Matsumoto

Int J Mol Sci· August 2021

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Cyclic Peptide-Based Biologics Regulating HGF-MET.
Hiroki Sato, Ryu Imamura, Hiroaki Suga, Kunio Matsumoto, Katsuya Sakai

Int J Mol Sci· October 2020

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Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation.
Yasuharu Watanabe, Yoshinori Nagai, Hiroe Honda, Naoki Okamoto, Tsutomu Yanagibashi, Ryu Imamura

FASEB J· November 2019

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Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer.
Wenyu Miao, Katsuya Sakai, Hiroki Sato, Ryu Imamura, Nawaphat Jangphattananont

Cancer Sci· October 2019

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Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis.
Kosuke Dodo, Erika Kuboki, Tadashi Shimizu, Ryu Imamura, Megumi Magarisawa

ACS Med Chem Lett· September 2019

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Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach.
Nawaphat Jangphattananont, Hiroki Sato, Ryu Imamura, Katsuya Sakai, Yumi Terakado

Int J Mol Sci· June 2019

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MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner.
Wenyu Miao, Katsuya Sakai, Ryu Imamura, Kenichiro Ito, Hiroaki Suga

Int J Mol Sci· October 2018

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Involvement of p38MAPK in Impaired Neutrophil Bactericidal Activity of Hemodialysis Patients.
Yasutaka Kamikawa, Norihiko Sakai, Taito Miyake, Akihiro Sagara, Yasuyuki Shinozaki, Ryu Imamura

Ther Apher Dial· August 2018

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Characterization of Innate and Adaptive Immune Responses in PYNOD-Deficient Mice.
Shinsuke Nakajima, Ryu Imamura, Miya Yoshino, Mayumi Sakurai, Kohsuke Tsuchiya

Immunohorizons· April 2018

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Hepatocyte growth factor in physiology and infectious diseases.
Ryu Imamura, Kunio Matsumoto

Cytokine· October 2017

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Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma.
Eri Adachi, Katsuya Sakai, Takumi Nishiuchi, Ryu Imamura, Hiroki Sato

Oncotarget· October 2016

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NLRP3 mediates NF-κB activation and cytokine induction in microbially induced and sterile inflammation.
Takeshi Kinoshita, Ryu Imamura, Hiroko Kushiyama, Takashi Suda

PLoS One· November 2015

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Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells.
Nanae Harashima, Tohko Inao, Ryu Imamura, Shinji Okano, Takashi Suda

Cancer Immunol Immunother· May 2012

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Fas Ligand Has a Greater Impact than TNF-α on Apoptosis and Inflammation in Ischemic Acute Kidney Injury.
Kengo Furuichi, Satoshi Kokubo, Akinori Hara, Ryu Imamura, Qiang Wang

Nephron Extra· January 2012

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Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity.
Kou Motani, Hiroko Kushiyama, Ryu Imamura, Takeshi Kinoshita, Takumi Nishiuchi

J Biol Chem· September 2011

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Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication.
Kou Motani, Kouji Kawase, Ryu Imamura, Takeshi Kinoshita, Hiroko Kushiyama

Cancer Sci· August 2010

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Anti-inflammatory activity of PYNOD and its mechanism in humans and mice.
Ryu Imamura, Yetao Wang, Takeshi Kinoshita, Misao Suzuki, Tetsuo Noda

J Immunol· May 2010

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Mechanism and repertoire of ASC-mediated gene expression.
Mizuho Hasegawa, Ryu Imamura, Kou Motani, Takumi Nishiuchi, Norihiko Matsumoto

J Immunol· June 2009

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Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production.
Norihiko Matsumoto, Ryu Imamura, Takashi Suda

FEBS J· May 2007

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