Publications by authors named "Emily M Stocking"

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Structure based design, synthesis and identification of novel covalent reversible dual TLR2/TLR9 small molecule antagonists.
Srinivasa Reddy Natala, Agata Habas, Emily M Stocking, Andrew Orry, Ruben Abagyan

Bioorg Med Chem Lett· August 2025

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NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation.
Agata Habas, Srinivasa Reddy Natala, Jon K Bowden-Verhoek, Emily M Stocking, Diana L Price

Int J Inflam· February 2022

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NPT520-34 improves neuropathology and motor deficits in a transgenic mouse model of Parkinson's disease.
Asma Khan, Robert Johnson, Carrie Wittmer, Michelle Maile, Keith Tatsukawa, Emily M Stocking

Brain· December 2021

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Structure based design and synthesis of novel Toll-like Receptor 2 (TLR 2) lipid antagonists.
Srinivasa Reddy Natala, Agata Habas, Emily M Stocking, Andrew Orry, Diana L Price

Bioorg Med Chem Lett· May 2021

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Exploration of structure-activity relationships for dual serotonin transporter reuptake inhibitors-histamine H3 receptor antagonists.
Emily M Stocking, Michael A Letavic, Pascal Bonaventure, Nicholas I Carruthers

Curr Top Med Chem· September 2010

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Synthesis of a histamine H(3) receptor antagonist-manipulation of hydroxyproline stereochemistry, desymmetrization of homopiperazine, and nonextractive sodium triacetoxyborohydride reaction workup.
Daniel J Pippel, Lana K Young, Michael A Letavic, Kiev S Ly, Bita Naderi, Emily M Stocking

J Org Chem· July 2010

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Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.
Emily M Stocking, Leah Aluisio, John R Atack, Pascal Bonaventure, Nicholas I Carruthers

Bioorg Med Chem Lett· May 2010

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Histamine H3 antagonists as wake-promoting and pro-cognitive agents.
Emily M Stocking, Michael A Letavic

Curr Top Med Chem· October 2008

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Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.
Kiev S Ly, Michael A Letavic, John M Keith, Jennifer M Miller, Emily M Stocking

Bioorg Med Chem Lett· January 2008

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Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.
Michael A Letavic, Emily M Stocking, Ann J Barbier, Pascal Bonaventure, Jamin D Boggs

Bioorg Med Chem Lett· September 2007

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Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity.
Emily M Stocking, Jennifer M Miller, Ann J Barbier, Sandy J Wilson, Jamin D Boggs

Bioorg Med Chem Lett· June 2007

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Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.
Michael A Letavic, John M Keith, Jill A Jablonowski, Emily M Stocking, Leslie A Gomez

Bioorg Med Chem Lett· February 2007

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Identification of novel inhibitors of bacterial translation elongation factors.
Maithri M K Jayasekera, Keysha Onheiber, John Keith, Hariharan Venkatesan, Alejandro Santillan, Emily M Stocking

Antimicrob Agents Chemother· January 2005

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Chemistry and biology of biosynthetic Diels-Alder reactions.
Emily M Stocking, Robert M Williams

Angew Chem Int Ed Engl· July 2003

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Studies on the Biosynthesis of Paraherquamide: Synthesis and Incorporation of a Hexacyclic Indole Derivative as an Advanced Metabolite This work was supported by the National Institutes of Health (Grant no. CA70375 to R.M.W.). We wish to acknowledge the American Chemical Society Division of Organic Chemistry Fellowship (sponsored by SmithKline Beecham) and the Pharmacia-Upjohn Company for financial support (to E.M.S.). Mass spectra were obtained on instruments supported by the National Institutes of Health Shared Instrumentation Grant (No. GM49631). We also wish to thank Professor Dean Crick of the Department of Microbiology at Colorado State University for helpful discussions. J.F.S.-C. thanks the DGICYT of Spain for a research grant (project no. PB98-1438).
Emily M. Stocking, Juan F. Sanz-Cervera, Robert M. Williams

Angew Chem Int Ed Engl· April 2001

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Reverse versus Normal Prenyl Transferases in Paraherquamide Biosynthesis Exhibit Distinct Facial Selectivities.
Emily M Stocking, Juan F Sanz-Cervera, Robert M Williams

Angew Chem Int Ed Engl· March 1999

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