Publications by authors named "Emma Lendy"

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Author Correction: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Laura Riva, Shuofeng Yuan, Xin Yin, Laura Martin-Sancho, Naoko Matsunaga, Emma K Lendy

Nature· July 2024

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A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes.
Ramya Visvanathan, Tadanobu Utsuki, Daniel E Beck, W Brent Clayton, Emma Lendy

PLoS One· April 2024

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Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors.
Arun K Ghosh, Monika Yadav, Satyanarayana Iddum, Somayeh Ghazi, Emma K Lendy

Eur J Med Chem· March 2024

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Development of a sensitive microplate assay for characterizing RNA methyltransferase activity: Implications for epitranscriptomics and drug development.
Isaiah K Mensah, Allison B Norvil, Ming He, Emma Lendy, Nicole Hjortland

J Biol Chem· October 2023

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Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.
Andy P Tsai, Chuanpeng Dong, Peter Bor-Chian Lin, Adrian L Oblak, Gonzalo Viana Di Prisco, Emma K Lendy

Immunity· September 2023

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A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer's disease.
Ramya Visvanathan, Tadanobu Utsuki, Daniel E Beck, Emma Lendy, Kuai-Lin Sun

SLAS Discov· June 2023

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Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies.
Arun K Ghosh, Jakka Raghavaiah, Dana Shahabi, Monika Yadav, Brandon J Anson, Emma K Lendy

J Med Chem· October 2021

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Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Britton Boras, Rhys M Jones, Brandon J Anson, Dan Arenson, Lisa Aschenbrenner, Emma K Lendy

Nat Commun· October 2021

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Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors.
Arun K Ghosh, Dana Shahabi, Monika Yadav, Satish Kovela, Brandon J Anson, Emma K Lendy

Molecules· September 2021

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Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.
Britton Boras, Rhys M Jones, Brandon J Anson, Dan Arenson, Lisa Aschenbrenner, Emma K Lendy

bioRxiv· February 2021

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A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication.
Shin-Ichiro Hattori, Nobuyo Higashi-Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Emma K Lendy

Nat Commun· January 2021

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Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Laura Riva, Shuofeng Yuan, Xin Yin, Laura Martin-Sancho, Naoko Matsunaga, Emma K Lendy

Nature· October 2020

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Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies.
Arun K Ghosh, Margherita Brindisi, Yu-Chen Yen, Emma K Lendy, Satish Kovela

ChemMedChem· March 2019

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Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.
Arun K Ghosh, Koena Ghosh, Margherita Brindisi, Emma K Lendy, Yu-Chen Yen

Bioorg Med Chem Lett· August 2018

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Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction.
Aamir Mir, Ji Chen, Kyle Robinson, Emma Lendy, Jaclyn Goodman

Biochemistry· October 2015

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