Publications by authors named "Emmanuel Onua"

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Oral toxicity and pharmacokinetic studies of SHetA2, a new chemopreventive agent, in rats and dogs.
Kasim K Kabirov, Izet M Kapetanovic, Doris M Benbrook, Nancy Dinger, Irina Mankovskaya, Emmanuel Onua

Drug Chem Toxicol· July 2013

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1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists.
Nian Zhou, Alexandre M Polozov, Matthew O'Connell, James Burgeson, Peng Yu, Emmanuel Onua

Bioorg Med Chem Lett· April 2010

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Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.
Vincent Sandanayaka, Bjorn Mamat, Rama K Mishra, Jennifer Winger, Michael Krohn, Emmanuel Onua

J Med Chem· January 2010

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Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that does not prolong bleeding.
Jasbir Singh, Wayne Zeller, Nian Zhou, Georgeta Hategan, Rama K Mishra, Emmanuel Onua

J Med Chem· January 2010

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Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051.
Livia A Enache, Jun Zhang, David W Sullins, Isaac Kennedy, Emmanuel Onua

Bioorg Med Chem Lett· November 2009

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3-Acrylamide-4-aryloxyindoles: synthesis, biological evaluation and metabolic stability of potent and selective EP3 receptor antagonists.
Nian Zhou, Wayne Zeller, Jun Zhang, Emmanuel Onua, Alex S Kiselyov

Bioorg Med Chem Lett· March 2009

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Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding.
Jasbir Singh, Wayne Zeller, Nian Zhou, Georgeta Hategen, Rama Mishra, Emmanuel Onua

ACS Chem Biol· February 2009

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3,4-Disubstituted indole acylsulfonamides: a novel series of potent and selective human EP3 receptor antagonists.
Nian Zhou, Wayne Zeller, Michael Krohn, Herb Anderson, Jun Zhang, Emmanuel Onua

Bioorg Med Chem Lett· January 2009

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Hepatic clearance and drug metabolism using isolated perfused rat liver.
Yong Liu, Steven J Weber, Emmanuel T Onua

Curr Protoc Pharmacol· October 2004

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