Publications by authors named "Emre Isin"

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Mass Spectrometry Imaging Reveals the Distribution of a GABRG2 Targeting Antisense Oligonucleotide and Its Functional Effect in Rat Brain.
Laura van der Vloet, Ronny Mohren, Christophe Bouillod, Georges Da Violante, Emre M Isin

ACS Chem Neurosci· October 2025

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How can MSI enhance our understanding of ASO distribution?
Laura van der Vloet, Pierre Barbier Saint Hilaire, Christophe Bouillod, Emre M Isin, Ron M A Heeren

Drug Discov Today· January 2025

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Unusual Biotransformation Reactions of Drugs and Drug Candidates.
Emre M Isin

Drug Metab Dispos· April 2023

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Meeting report of the 3rd European Biotransformation Workshop.
Markus Walles, Axel Pähler, Emre M Isin, Marie M Ahlqvist

Xenobiotica· February 2023

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Multimodal molecular imaging in drug discovery and development.
Isabeau Vermeulen, Emre M Isin, Patrick Barton, Berta Cillero-Pastor, Ron M A Heeren

Drug Discov Today· August 2022

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Setup of human liver-chips integrating 3D models, microwells and a standardized microfluidic platform as proof-of-concept study to support drug evaluation.
Benoit Cox, Patrick Barton, Reiner Class, Hannah Coxhead, Claude Delatour, Emre M Isin

Biomater Biosyst· August 2022

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The effect of ketoconazole on praziquantel pharmacokinetics and the role of CYP3A4 in the formation of X-OH-praziquantel and not 4-OH-praziquantel.
Lovejoy Nleya, Roslyn Thelingwani, Xue-Qing Li, Erika Cavallin, Emre Isin

Eur J Clin Pharmacol· August 2019

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Human hepatocytes and cytochrome P450-selective inhibitors predict variability in human drug exposure more accurately than human recombinant P450s.
Bo Lindmark, Anna Lundahl, Kajsa P Kanebratt, Tommy B Andersson, Emre M Isin

Br J Pharmacol· June 2018

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Introduction: Mass Spectrometry and Emerging Technologies for Biomarker Discovery in the Assessment of Human Health and Disease.
Emre M Isin, Robert J Turesky

Chem Res Toxicol· December 2016

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Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data.
Jessica Iegre, Martin A Hayes, Richard A Thompson, Lars Weidolf, Emre M Isin

Drug Metab Dispos· May 2016

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Reactive Metabolites: Current and Emerging Risk and Hazard Assessments.
Richard A Thompson, Emre M Isin, Monday O Ogese, Jerome T Mettetal, Dominic P Williams

Chem Res Toxicol· April 2016

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Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes.
Malin Darnell, Katarina Breitholtz, Emre M Isin, Ulrik Jurva, Lars Weidolf

Chem Res Toxicol· May 2015

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Use of electrochemical oxidation and model peptides to study nucleophilic biological targets of reactive metabolites: the case of rimonabant.
Annika Thorsell, Emre M Isin, Ulrik Jurva

Chem Res Toxicol· October 2014

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Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite.
Alison J Foster, Lucy H Prime, Frida Gustafsson, David G Temesi, Emre M Isin

Chem Res Toxicol· January 2013

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In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.
Richard A Thompson, Emre M Isin, Yan Li, Lars Weidolf, Ken Page

Chem Res Toxicol· August 2012

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Use of radiolabeled compounds in drug metabolism and pharmacokinetic studies.
Emre M Isin, Charles S Elmore, Göran N Nilsson, Richard A Thompson, Lars Weidolf

Chem Res Toxicol· March 2012

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Bioactivation pathways of the cannabinoid receptor 1 antagonist rimonabant.
Moa Andresen Bergström, Emre M Isin, Neal Castagnoli, Claire E Milne

Drug Metab Dispos· October 2011

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Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development.
Richard A Thompson, Emre M Isin, Yan Li, Richard Weaver, Lars Weidolf

Chem Biol Interact· June 2011

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Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
Christoffer Bengtsson, Stefan Blaho, David Blomberg Saitton, Kay Brickmann, Johan Broddefalk, Emre Isin

Bioorg Med Chem· May 2011

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Substrate binding to cytochromes P450.
Emre M Isin, F Peter Guengerich

Anal Bioanal Chem· November 2008

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The tert-butoxyl radical mediated hydrogen atom transfer reactions of the Parkinsonian proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and selected tertiary amines.
N Kamrudin Suleman, Joey Flores, James M Tanko, Emre Mehmet Isin, Neal Castagnoli

Bioorg Med Chem· September 2008

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Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene.
Emre M Isin, Christal D Sohl, Robert L Eoff, F Peter Guengerich

Arch Biochem Biophys· May 2008

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Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding.
Christal D Sohl, Emre M Isin, Robert L Eoff, Glenn A Marsch, Donald F Stec

J Biol Chem· March 2008

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Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli.
Dong-Hyun Kim, Keon-Hee Kim, Emre M Isin, F Peter Guengerich, Ho Zoon Chae

Protein Expr Purif· February 2008

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Complex reactions catalyzed by cytochrome P450 enzymes.
Emre M Isin, F Peter Guengerich

Biochim Biophys Acta· March 2007

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