Publications by authors named "Eric B Harstad"

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The Vedotin Antibody-Drug Conjugate Payload Drives Platform-Based Nonclinical Safety and Pharmacokinetic Profiles.
Haley D Neff-LaFord, Sarah A Carratt, Christopher Carosino, Nancy Everds, Kristen A Cardinal, Eric B Harstad

Mol Cancer Ther· October 2024

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Gut-Selective Design of Orally Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species.
Rhiannon N Hardwick, Patrick Brassil, Ilaria Badagnani, Kimberly Perkins, Glenmar P Obedencio, Eric B Harstad

Toxicol Sci· March 2022

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Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.
Xiaojing Wang, Wesley Blackaby, Vivienne Allen, Grace Ka Yan Chan, Jae H Chang, Eric B Harstad

J Med Chem· February 2019

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DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues.
Eric B Harstad, Jonathan S Rosenblum, Mark D Gorrell, William E Achanzar, Lauro Minimo

Regul Pept· September 2013

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Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.
Dolores Diaz, Kevin A Ford, Dylan P Hartley, Eric B Harstad, Gary R Cain

Toxicol Appl Pharmacol· January 2013

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Preclinical stereoselective disposition and toxicokinetics of two novel MET inhibitors.
Bianca M Liederer, Xingrong Liu, Leonid M Berezhkovskiy, Gary Cain, Xiao Ding, Eric B Harstad

Xenobiotica· May 2012

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Liver deformation in Ahr-null mice: evidence for aberrant hepatic perfusion in early development.
Eric B Harstad, Christopher A Guite, Tami L Thomae, Christopher A Bradfield

Mol Pharmacol· May 2006

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Patent ductus venosus and dioxin resistance in mice harboring a hypomorphic Arnt allele.
Jacqueline A Walisser, Maureen K Bunger, Edward Glover, Eric B Harstad, Christopher A Bradfield

J Biol Chem· April 2004

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Analysis of strain difference in sensitivity to cadmium-induced hepatotoxicity in Fischer 344 and Sprague-Dawley rats.
Eric B Harstad, Curtis D Klaassen

Toxicol Sci· June 2002

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iNOS-null mice are not resistant to cadmium chloride-induced hepatotoxicity.
Eric B Harstad, Curtis D Klaassen

Toxicology· June 2002

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Gadolinium chloride pretreatment prevents cadmium chloride-induced liver damage in both wild-type and MT-null mice.
Eric B Harstad, Curtis D Klaassen

Toxicol Appl Pharmacol· May 2002

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Tumor necrosis factor-alpha-null mice are not resistant to cadmium chloride-induced hepatotoxicity.
Eric B Harstad, Curtis D Klaassen

Toxicol Appl Pharmacol· March 2002

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