Publications by authors named "Eric B Kmiec"

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Functional characterization of tumor-specific CRISPR-directed gene editing as a combinatorial therapy for the treatment of solid tumors.
Kelly H Banas, Pawel A Bialk, Natalia Rivera-Torres, Katelynn Owens, Tori N Reiner, Eric B Kmiec

Mol Ther Oncol· December 2025

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Editor's Corner: Interallelic Gene Conversion.
Eric B Kmiec

Gene· September 2025

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CRISPR-directed exon skipping; friend or foe (opportunity or warning sign)?
Kelly H Banas, Eric B Kmiec

Mol Ther Nucleic Acids· June 2025

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CRISPR-directed gene-editing induces genetic rearrangement within the human globin gene locus.
Olivia Tharp, Brett M Sansbury, Eric B Kmiec

Gene· December 2024

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Mutation-Specific CRISPR Targeting with SaCas9 and AsCas12a Restores Therapeutic Sensitivity in Treatment-Resistant Melanoma.
Brett M Sansbury, Sophia B Masciarelli, Salma Kaouser, Olivia M Tharp, Kelly H Banas, Eric B Kmiec

CRISPR J· December 2024

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CRISPR-Directed Gene Editing as a Method to Reduce Chemoresistance in Lung Cancer Cells.
Natalia Rivera-Torres, Pawel Bialk, Eric B Kmiec

Methods Mol Biol· May 2023

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Genome editing before CRISPR: The gnostic bible.
Eric B Kmiec

Mol Ther Nucleic Acids· March 2023

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Exon skipping induced by CRISPR-directed gene editing regulates the response to chemotherapy in non-small cell lung carcinoma cells.
Kelly Banas, Shirin Modarai, Natalia Rivera-Torres, Byung-Chun Yoo, Pawel A Bialk, Eric B Kmiec

Gene Ther· June 2022

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Homology directed correction, a new pathway model for point mutation repair catalyzed by CRISPR-Cas.
Brett M Sansbury, Amanda M Hewes, Olivia M Tharp, Sophia B Masciarelli, Salma Kaouser, Eric B Kmiec

Sci Rep· May 2022

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From the Guest Editor.
Eric B Kmiec

Dela J Public Health· December 2021

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A toolmaker's perspective on CRISPR-directed gene editing as a therapeutic strategy for leukemia and beyond.
Eric B Kmiec, Kevin Bloh

Expert Rev Hematol· July 2021

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On the Origins of Homology Directed Repair in Mammalian Cells.
Brett M Sansbury, Eric B Kmiec

Int J Mol Sci· March 2021

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Precise and error-prone CRISPR-directed gene editing activity in human CD34+ cells varies widely among patient samples.
Shirin R Modarai, Sambee Kanda, Kevin Bloh, Lynn M Opdenaker, Eric B Kmiec

Gene Ther· February 2021

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Deconvolution of Complex DNA Repair (DECODR): Establishing a Novel Deconvolution Algorithm for Comprehensive Analysis of CRISPR-Edited Sanger Sequencing Data.
Kevin Bloh, Rohan Kanchana, Pawel Bialk, Kelly Banas, Zugui Zhang, Eric B Kmiec

CRISPR J· February 2021

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Modeling pediatric AML FLT3 mutations using CRISPR/Cas12a- mediated gene editing.
Natalia Rivera-Torres, Kelly Banas, Eric B Kmiec

Leuk Lymphoma· December 2020

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The Diversity of Genetic Outcomes from CRISPR/Cas Gene Editing is Regulated by the Length of the Symmetrical Donor DNA Template.
Amanda M Hewes, Brett M Sansbury, Eric B Kmiec

Genes (Basel)· September 2020

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Understanding the diversity of genetic outcomes from CRISPR-Cas generated homology-directed repair.
Brett M Sansbury, Amanda M Hewes, Eric B Kmiec

Commun Biol· July 2020

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Perspectives on Molecular Diagnostic Testing for the COVID-19 Pandemic in Delaware.
Erin L Crowgey, Mary M Lee, Brett Sansbury, Eric B Kmiec

Dela J Public Health· July 2020

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Kinetics of Nuclear Uptake and Site-Specific DNA Cleavage during CRISPR-Directed Gene Editing in Solid Tumor Cells.
Kelly Banas, Natalia Rivera-Torres, Pawel Bialk, Byung-Chun Yoo, Eric B Kmiec

Mol Cancer Res· June 2020

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gRNA Sequence Heterology Tolerance Catalyzed by CRISPR/Cas in an In Vitro Homology-Directed Repair Reaction.
Amanda M Hewes, Brett M Sansbury, Shaul Barth, Gabi Tarcic, Eric B Kmiec

Mol Ther Nucleic Acids· June 2020

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CRISPR-Directed Gene Editing Catalyzes Precise Gene Segment Replacement Enabling a Novel Method for Multiplex Site-Directed Mutagenesis.
Brett M Sansbury, Amanda M Wagner, Gabi Tarcic, Shaul Barth, Erez Nitzan, Eric B Kmiec

CRISPR J· April 2019

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Functional Gene Knockout of Increases Chemosensitivity of Human Lung Cancer A549 Cells and in a Xenograft Mouse Model.
Pawel Bialk, Yichen Wang, Kelly Banas, Eric B Kmiec

Mol Ther Oncolytics· December 2018

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Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex.
Shirin R Modarai, Dula Man, Pawel Bialk, Natalia Rivera-Torres, Kevin Bloh, Eric B Kmiec

Mol Ther Nucleic Acids· June 2018

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CRISPR-Directed Gene Editing of Plasmid DNA Catalyzed by Cpf1 (Cas12a) Nuclease and a Mammalian Cell-Free Extract.
Brett M Sansbury, Amanda M Wagner, Erez Nitzan, Gabi Tarcic, Eric B Kmiec

CRISPR J· April 2018

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A Standard Methodology to Examine On-site Mutagenicity As a Function of Point Mutation Repair Catalyzed by CRISPR/Cas9 and SsODN in Human Cells.
Natalia Rivera-Torres, Eric B Kmiec

J Vis Exp· August 2017

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