Publications by authors named "Shirin Modarai"

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Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer.
Chunlei Shao, Alexandra Indeglia, Maya Foster, Kaitlyn Casey, Jessica Leung, Shirin R Modarai

Genes Dev· November 2025

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CRISPR/Cas9 Targeting of Aldehyde Dehydrogenase 1A1 Reveals Heterogeneous Roles in Radiation Response and Redox Stress Across Clonal Lines in Triple-Negative Breast Cancer.
Grace O Ajayi, Aihui Ma, Shirin R Modarai, Lynn M Opdenaker, Jennifer Sims-Mourtada

Int J Mol Sci· March 2025

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B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer.
Nicole J Toney, Lynn M Opdenaker, Lisa Frerichs, Shirin R Modarai, Aihui Ma

Sci Rep· January 2025

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B cells enhance IL-1 beta driven invasiveness in triple-negative breast cancer.
Nicole J Toney, Lynn M Opdenaker, Lisa Frerichs, Shirin R Modarai, Aihui Ma

Res Sq· December 2024

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Beyond the Genetic Code:
Bruce M Boman, Thien-Nam Dinh, Keith Decker, Brooks Emerick, Shirin Modarai

bioRxiv· March 2023

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Exon skipping induced by CRISPR-directed gene editing regulates the response to chemotherapy in non-small cell lung carcinoma cells.
Kelly Banas, Shirin Modarai, Natalia Rivera-Torres, Byung-Chun Yoo, Pawel A Bialk

Gene Ther· June 2022

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Precise and error-prone CRISPR-directed gene editing activity in human CD34+ cells varies widely among patient samples.
Shirin R Modarai, Sambee Kanda, Kevin Bloh, Lynn M Opdenaker, Eric B Kmiec

Gene Ther· February 2021

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APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development.
Tao Zhang, Koree Ahn, Brooks Emerick, Shirin R Modarai, Lynn M Opdenaker

PLoS One· November 2020

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MicroRNA Expression Profiling of Normal and Malignant Human Colonic Stem Cells Identifies as a Regulator of the Stem Cell Gene.
Vignesh Viswanathan, Lynn Opdenaker, Shirin Modarai, Jeremy Z Fields, Gregory Gonye

Int J Mol Sci· April 2020

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The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells.
Shirin R Modarai, Anindita Gupta, Lynn M Opdenaker, Ryan Kowash, Gabriel Masters

Oncotarget· October 2018

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Increased Musashi-2 and Decreased NUMB Protein Levels Observed in Human Colorectal Cancer are reverted to Normal Levels by ATRA-Induced Cell Differentiation.
Lynn M Opdenaker, Ryan Kowash, Gabriel Masters, Bruce M Boman, Tao Zhang, Shirin R Modarai

Int J Cancer Res Ther· August 2018

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Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex.
Shirin R Modarai, Dula Man, Pawel Bialk, Natalia Rivera-Torres, Kevin Bloh

Mol Ther Nucleic Acids· June 2018

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An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia.
Vignesh Viswanathan, Shirish Damle, Tao Zhang, Lynn Opdenaker, Shirin Modarai

Cancer Res· July 2017

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Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells.
Shirin R Modarai, Lynn M Opdenaker, Vignesh Viswanathan, Jeremy Z Fields, Bruce M Boman

BMC Cancer· December 2016

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The Proportion of ALDEFLUOR-Positive Cancer Stem Cells Changes with Cell Culture Density Due to the Expression of Different ALDH Isoforms.
Lynn M Opdenaker, Shirin R Modarai, Bruce M Boman

Cancer Stud Mol Med· December 2015

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