Publications by authors named "Eric D Spear"

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Analysis of a degron-containing reporter protein GFP-CL1 reveals a role for SUMO1 in cytosolic protein quality control.
Wei Wang, Jian Lu, Wei-Chih Yang, Eric D Spear, Susan Michaelis

J Biol Chem· February 2023

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The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation.
Khurts Shilagardi, Eric D Spear, Rachy Abraham, Diane E Griffin, Susan Michaelis

mBio· October 2022

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Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice.
Yuexia Wang, Khurts Shilagardi, Trunee Hsu, Kamsi O Odinammadu, Takamitsu Maruyama, Eric D Spear

Proc Natl Acad Sci U S A· March 2022

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Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24.
Timothy D Babatz, Eric D Spear, Wenxin Xu, Olivia L Sun, Laiyin Nie

J Biol Chem· August 2021

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Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24.
Kaitlin M Wood, Eric D Spear, Otto W Mossberg, Kamsi O Odinammadu, Wenxin Xu

PLoS One· January 2021

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A humanized yeast system to analyze cleavage of prelamin A by ZMPSTE24.
Eric D Spear, Rebecca F Alford, Tim D Babatz, Kaitlin M Wood, Otto W Mossberg

Methods· March 2019

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missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability.
Eric D Spear, Erh-Ting Hsu, Laiyin Nie, Elisabeth P Carpenter, Christine A Hrycyna

Dis Model Mech· July 2018

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Degradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast.
Matthew J Maurer, Eric D Spear, Allen T Yu, Evan J Lee, Saba Shahzad

G3 (Bethesda)· July 2016

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Mapping the cellular response to small molecules using chemogenomic fitness signatures.
Anna Y Lee, Robert P St Onge, Michael J Proctor, Iain M Wallace, Aaron H Nile, Eric D Spear

Science· April 2014

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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Liron Bar-Peled, Lynne Chantranupong, Andrew D Cherniack, Walter W Chen, Kathleen A Ottina, Eric D Spear

Science· May 2013

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Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals.
Konstantin Kogan, Eric D Spear, Chris A Kaiser, Deborah Fass

J Mol Biol· September 2010

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The genetic landscape of a cell.
Michael Costanzo, Anastasia Baryshnikova, Jeremy Bellay, Yungil Kim, Eric D Spear

Science· January 2010

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Structural evidence for common ancestry of the nuclear pore complex and vesicle coats.
Stephen G Brohawn, Nina C Leksa, Eric D Spear, Kanagalaghatta R Rajashankar, Thomas U Schwartz

Science· November 2008

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Yos9p detects and targets misfolded glycoproteins for ER-associated degradation.
Woong Kim, Eric D Spear, Davis T W Ng

Mol Cell· September 2005

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Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation.
Eric D Spear, Davis T W Ng

J Cell Biol· April 2005

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Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradative pathways.
Eric D Spear, Davis T W Ng

Mol Biol Cell· July 2003

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