Publications by authors named "Eric Hostetler"

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Alzheimer's Imaging Consortium.
Alexis Moscoso, Antoine Leuzy, Lars Lau Raket, Victor L Villemagne, Gregory Klein, Eric D Hostetler

Alzheimers Dement· December 2025

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Preclinical evaluation of MK-8189: A novel phosphodiesterase 10A inhibitor for the treatment of schizophrenia.
Sean M Smith, Dawn Toolan, Monika Kandebo, Joshua Vardigan, Izzat Raheem, Eric Hostetler

J Pharmacol Exp Ther· January 2025

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Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model.
Antoine Leuzy, Lars Lau Raket, Victor L Villemagne, Gregory Klein, Matteo Tonietto, Eric Hostetler

Alzheimers Dement· September 2024

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Discovery of [C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR Negative Allosteric Modulators.
James J Perkins, Paul McQuade, Christopher J Bungard, Tracy L Diamond, Liza T Gantert, Eric Hostetler

ACS Med Chem Lett· July 2023

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Training the next generation of radiopharmaceutical scientists.
Antony D Gee, Jan Andersson, Rajiv Bhalla, Yearn Seong Choe, David W Dick, Eric D Hostetler

Nucl Med Biol· February 2022

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The PET tracer [C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease.
Wenping Li, Yuchuan Wang, Talakad G Lohith, Zhizhen Zeng, Ling Tong, Eric D Hostetler

Sci Transl Med· January 2022

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A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [F]MK-6240.
Guilherme D Kolinger, David Vállez García, Talakad G Lohith, Eric D Hostetler, Cyrille Sur

EJNMMI Res· May 2021

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In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1.
Daniel J Rubins, Xiangjun Meng, Paul McQuade, Michael Klimas, Krista Getty, Eric D Hostetler

Mol Imaging Biol· April 2021

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PET/CT Imaging of Zr-N-sucDf-Pembrolizumab in Healthy Cynomolgus Monkeys.
Wenping Li, Yuchuan Wang, Daniel Rubins, Idriss Bennacef, Marie Holahan, Eric D Hostetler

Mol Imaging Biol· April 2021

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Preclinical evaluation of [ C]L-235 as a radioligand for Positron Emission Tomography cathepsin K imaging in bone.
Idriss Bennacef, Daniel Rubins, Kerry Riffel, Mangay Williams, Diane J Posavec, Eric D Hostetler

J Labelled Comp Radiopharm· April 2021

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Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery.
Robert W Pipal, Kenneth T Stout, Patricia Z Musacchio, Sumei Ren, Thomas J A Graham, Eric D Hostetler

Nature· January 2021

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MK-8719, a Novel and Selective -GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy.
Xiaohai Wang, Wenping Li, Jacob Marcus, Michelle Pearson, Lixin Song, Eric Hostetler

J Pharmacol Exp Ther· August 2020

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Discovery of [C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases.
Ling Tong, Wenping Li, Michael Man-Chu Lo, Xiaolei Gao, Jenny Miu-Chen Wai, Eric Hostetler

J Med Chem· March 2020

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Preclinical Safety Evaluation and Human Dosimetry of [F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles.
Michel Koole, Talakad G Lohith, John L Valentine, Idriss Bennacef, Ruben Declercq, Eric D Hostetler

Mol Imaging Biol· February 2020

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Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor.
Eric Moore, Mark E Fraley, Ian M Bell, Christopher S Burgey, Rebecca B White, Eric Hostetler

J Pharmacol Exp Ther· January 2020

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Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles.
Talakad G Lohith, Idriss Bennacef, Rik Vandenberghe, Mathieu Vandenbulcke, Cristian A Salinas, Eric D Hostetler

J Nucl Med· January 2019

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In Vivo Imaging of the Programmed Death Ligand 1 by F PET.
Dinko E González Trotter, Xiangjun Meng, Paul McQuade, Daniel Rubins, Michael Klimas, Eric D Hostetler

J Nucl Med· November 2017

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cGMP production of the radiopharmaceutical [ F]MK-6240 for PET imaging of human neurofibrillary tangles.
Thomas Lee Collier, Daniel L Yokell, Eli Livni, Peter A Rice, Sofie Celen, Eric D Hostetler

J Labelled Comp Radiopharm· May 2017

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fMRI study of the role of glutamate NMDA receptor in the olfactory adaptation in rats: Insights into cellular and molecular mechanisms of olfactory adaptation.
Fuqiang Zhao, Xiaohai Wang, Hatim A Zariwala, Jason M Uslaner, Andrea K Houghton, Eric Hostetler

Neuroimage· April 2017

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Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles.
Eric D Hostetler, Abbas M Walji, Zhizhen Zeng, Patricia Miller, Idriss Bennacef

J Nucl Med· October 2016

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Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [(11)C]MK-8193.
Eric D Hostetler, Hong Fan, Aniket D Joshi, Zhizhen Zeng, Waisi Eng

Mol Imaging Biol· August 2016

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Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs).
Abbas M Walji, Eric D Hostetler, Harold Selnick, Zhizhen Zeng, Patricia Miller

J Med Chem· May 2016

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Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Izzat T Raheem, John D Schreier, Joy Fuerst, Liza Gantert, Eric D Hostetler

Bioorg Med Chem Lett· January 2016

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Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors.
Christopher D Cox, Eric D Hostetler, Broc A Flores, Jeffrey L Evelhoch, Hong Fan

Bioorg Med Chem Lett· November 2015

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[(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor.
Ian M Bell, Steven N Gallicchio, Craig A Stump, Joseph G Bruno, Hong Fan, Eric D Hostetler

ACS Med Chem Lett· September 2013

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