Publications by authors named "Eric J Woolf"

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Incorporating protein precipitation to resolve hybrid IP-LC-MS assay interference for ultrasensitive quantification of intact therapeutic insulin dimer in human plasma.
Li Sun, Yang Xu, Neal Dube, Melanie Anderson, Sheila Breidinger, Eric J Woolf

J Pharm Biomed Anal· April 2022

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Volumetric absorptive microsampling (VAMS®) in therapeutic protein quantification by LC-MS/MS: Investigation of anticoagulant impact on assay performance and recommendations for best practices in method development.
Xinliu Gao, Cindy Chen, Dong Geng, Kevin P Bateman, Shuangping Shi, Eric J Woolf

J Pharm Biomed Anal· March 2021

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Learning how to interpret 'dangerous' internal standard behaviors.
Eric J Woolf

Bioanalysis· September 2019

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Perspectives on the draft ICH-M10 guidance: an interview with Eric J Woolf.
Eric J Woolf

Bioanalysis· August 2019

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Toward highly sensitive and reproducible LC-MS/MS analysis of MK-8591 phosphorylated anabolites in human peripheral blood mononuclear cells.
Li Sun, Cynthia Chavez-Eng, Kerry L Fillgrove, Bing Lu, Iris Xie, Eric J Woolf

Bioanalysis· February 2019

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Strategy for peptide quantification using LC-MS in regulated bioanalysis: case study with a glucose-responsive insulin.
Yang Xu, Dina Goykhman, Ming Wang, Tonya Jackson, Iris Xie, Eric J Woolf

Bioanalysis· August 2018

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Novel Application of the Two-Period Microtracer Approach to Determine Absolute Oral Bioavailability and Fraction Absorbed of Ertugliflozin.
Sangeeta Raje, Ernesto Callegari, Vaishali Sahasrabudhe, Alfin Vaz, Haihong Shi, Eric J Woolf

Clin Transl Sci· July 2018

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Extractability-mediated stability bias and hematocrit impact: High extraction recovery is critical to feasibility of volumetric adsorptive microsampling (VAMS) in regulated bioanalysis.
Iris Xie, Yang Xu, Melanie Anderson, Ming Wang, Lingling Xue, Eric J Woolf

J Pharm Biomed Anal· July 2018

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Insulin glargine and its two active metabolites: A sensitive (16pM) and robust simultaneous hybrid assay coupling immunoaffinity purification with LC-MS/MS to support biosimilar clinical studies.
Yang Xu, Li Sun, Melanie Anderson, Philippe Bélanger, Vincent Trinh, Eric J Woolf

J Chromatogr B Analyt Technol Biomed Life Sci· September 2017

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A device for dried blood microsampling in quantitative bioanalysis: overcoming the issues associated blood hematocrit.
Neil Spooner, Philip Denniff, Luc Michielsen, Ronald De Vries, Qin C Ji, Eric J Woolf

Bioanalysis· January 2016

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Direct comparison of radioimmunoassay and LC-MS/MS for PK assessment of insulin glargine in clinical development.
Yang Xu, Marita Prohn, Xiaoyan Cai, Michael Crutchlow, Sudha S Shankar, Eric J Woolf

Bioanalysis· August 2015

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Small molecule specific run acceptance, specific assay operation, and chromatographic run quality assessment: recommendation for best practices and harmonization from the global bioanalysis consortium harmonization teams.
Eric J Woolf, Stuart McDougall, Douglas M Fast, Maristela Andraus, Matthew Barfield

AAPS J· September 2014

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Merck's perspective on the implementation of dried blood spot technology in clinical drug development - why, when and how.
Yang Xu, Eric J Woolf, Nancy Gb Agrawal, Prajakti Kothare, Vincenzo Pucci

Bioanalysis· February 2013

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Evaluation of dried blood spot (DBS) technology versus plasma analysis for the determination of MK-1775 by HILIC-MS/MS in support of clinical studies.
Yang Xu, Wei Fang, Wei Zeng, Suzanne Leijen, Eric J Woolf

Anal Bioanal Chem· December 2012

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Ultrasensitive liquid chromatography-tandem mass spectrometric methodologies for quantification of five HIV-1 integrase inhibitors in plasma for a microdose clinical trial.
Li Sun, Hankun Li, Kenneth Willson, Sheila Breidinger, Matthew L Rizk, Eric J Woolf

Anal Chem· October 2012

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Quantitative determination of odanacatib in human plasma using liquid-liquid extraction followed by liquid chromatography-tandem mass spectrometry analysis.
Li Sun, Sabrina Forni, Michael S Schwartz, Sheila Breidinger, Eric J Woolf

J Chromatogr B Analyt Technol Biomed Life Sci· February 2012

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Immunoaffinity purification using anti-PEG antibody followed by two-dimensional liquid chromatography/tandem mass spectrometry for the quantification of a PEGylated therapeutic peptide in human plasma.
Yang Xu, John T Mehl, Ray Bakhtiar, Eric J Woolf

Anal Chem· August 2010

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Determination of sitagliptinin human plasma using protein precipitation and tandem mass spectrometry.
Wei Zeng, Yang Xu, Marvin Constanzer, Eric J Woolf

J Chromatogr B Analyt Technol Biomed Life Sci· July 2010

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Hydrophilic interaction chromatography/tandem mass spectrometry for the simultaneous determination of three polar non-structurally related compounds, imipenem, cilastatin and an investigational beta-lactamase inhibitor, MK-4698, in biological matrices.
Yang Xu, Wei Xie, Cynthia M Miller-Stein, Eric J Woolf

Rapid Commun Mass Spectrom· July 2009

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Elimination of diastereomer interference to determine Telcagepant (MK-0974) in human plasma using on-line turbulent-flow technology and off-line solid-phase extraction coupled with liquid chromatography/tandem mass spectrometry.
Yang Xu, Kenneth J Willson, Melanie D G Anderson, Donald G Musson, Cynthia M Miller-Stein, Eric J Woolf

J Chromatogr B Analyt Technol Biomed Life Sci· June 2009

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A flexible and high throughput liquid chromatography-tandem mass spectrometric assay for the quantitation of telcagepant in human plasma.
Lihong Du, Cynthia M Miller-Stein, Robert J Valesky, Ashley N Martucci, Eric J Woolf

J Chromatogr B Analyt Technol Biomed Life Sci· May 2009

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Determination of sitagliptin in human urine and hemodialysate using turbulent flow online extraction and tandem mass spectrometry.
Wei Zeng, Donald G Musson, Alison L Fisher, Li Chen, Michael S Schwartz, Eric J Woolf

J Pharm Biomed Anal· February 2008

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Determination of a novel gamma-secretase inhibitor in human plasma and cerebrospinal fluid using automated 96 well solid phase extraction and liquid chromatography/tandem mass spectrometry.
Catherine Z Matthews, Eric J Woolf

J Chromatogr B Analyt Technol Biomed Life Sci· February 2008

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Concerns in the development of an assay for determination of a highly conjugated adsorption-prone compound in human urine.
Yang Xu, Lihong Du, Mark J Rose, Irong Fu, Eric J Woolf

J Chromatogr B Analyt Technol Biomed Life Sci· April 2005

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The effects of modifying in vivo cytochrome P450 3A (CYP3A) activity on etoricoxib pharmacokinetics and of etoricoxib administration on CYP3A activity.
Nancy G B Agrawal, Catherine Z Matthews, Ralph S Mazenko, Eric J Woolf, Arturo G Porras

J Clin Pharmacol· October 2004

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