Publications by authors named "Eric Karran"

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Development of a robust, physiologically relevant neuronal tau aggregation assay for tau-related drug discovery.
Jessica W Wu, Katherine Titterton, Rebecca Sebastian, Nandini Romanul, Kiran Yanamandra, Eric Karran

J Biol Chem· October 2025

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Cell-death pathways and tau-associated neuronal vulnerability in Alzheimer's disease.
Gen Lin, Sarah E Chancellor, Taekyung Kwon, Maya E Woodbury, Astrid Doering, Eric H Karran

Cell Rep· June 2025

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Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis.
Fan Liao, Maria Calvo-Rodriguez, Meha Chhaya, Julian P Sefrin, Erik I Charych, Eric Karran

Acta Neuropathol· June 2025

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Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease.
Alberto Serrano-Pozo, Huan Li, Zhaozhi Li, Clara Muñoz-Castro, Methasit Jaisa-Aad, Eric H Karran

Nat Neurosci· December 2024

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Broad proteomics analysis of seeding-induced aggregation of α-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinson's disease pathogenesis.
Casey J Lumpkin, Hiral Patel, Gregory K Potts, Shilpi Chaurasia, Lauren Gibilisco, Eric Karran

Mol Brain· May 2024

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Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau.
Astrid Wachter, Maya E Woodbury, Sylvia Lombardo, Aicha Abdourahman, Carolin Wuest, Eric H Karran

Acta Neuropathol· April 2024

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New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases.
Bart De Strooper, Eric Karran

EMBO J· March 2024

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Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease.
Sudeshna Das, Zhaozhi Li, Astrid Wachter, Srinija Alla, Ayush Noori, Eric H Karran

Alzheimers Dement· January 2024

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Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease.
Annie Bryant, Zhaozhi Li, Rojashree Jayakumar, Alberto Serrano-Pozo, Benjamin Woost, Eric H Karran

J Neurosci· June 2023

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Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and in Alzheimer's Disease.
Sudeshna Das, Zhaozhi Li, Astrid Wachter, Srinija Alla, Ayush Noori, Eric H Karran

bioRxiv· March 2023

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Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer's Disease.
Annie Bryant, Zhaozhi Li, Rojashree Jayakumar, Alberto Serrano-Pozo, Benjamin Woost, Eric H Karran

bioRxiv· February 2023

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The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics.
Eric Karran, Bart De Strooper

Nat Rev Drug Discov· April 2022

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Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model.
Justine D Manos, Christina N Preiss, Nandini Venkat, Joseph Tamm, Peter Reinhardt, Eric Karran

iScience· January 2022

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MEK1/2 activity modulates TREM2 cell surface recruitment.
Jason Schapansky, Yelena Y Grinberg, David M Osiecki, Emily A Freeman, Stephen G Walker, Eric Karran

J Biol Chem· August 2021

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Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration.
Juliane Obst, Emilie Simon, Maria Martin-Estebane, Elena Pipi, Liana M Barkwill, Eric Karran

Front Immunol· June 2021

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Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer's disease model.
Lishu Duan, Mufeng Hu, Joseph A Tamm, Yelena Y Grinberg, Fang Shen, Eric Karran

Sci Rep· February 2021

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Author Correction: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
Farah H Siddiqi, Fiona M Menzies, Ana Lopez, Eleanna Stamatakou, Cansu Karabiyik, Eric Karran

Nat Commun· June 2019

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Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
Farah H Siddiqi, Fiona M Menzies, Ana Lopez, Eleanna Stamatakou, Cansu Karabiyik, Eric Karran

Nat Commun· April 2019

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The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.
Carlo Sala Frigerio, Leen Wolfs, Nicola Fattorelli, Nicola Thrupp, Iryna Voytyuk, Eric Karran

Cell Rep· April 2019

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Precision pharmacology for Alzheimer's disease.
Harald Hampel, Andrea Vergallo, Lisi Flores Aguilar, Norbert Benda, Karl Broich, Eric Karran

Pharmacol Res· April 2018

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Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.
Elena Redondo-Castro, Dorte Faust, Simon Fox, Alex G Baldwin, Simon Osborne, Eric Karran

Sci Rep· April 2018

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The amyloid cascade hypothesis: are we poised for success or failure?
Eric Karran, Bart De Strooper

J Neurochem· October 2016

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The Cellular Phase of Alzheimer's Disease.
Bart De Strooper, Eric Karran

Cell· February 2016

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Recent trial shows that solanezumab has disease modifying effects.
Eric Karran

BMJ· August 2015

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Eric Karran.
Eric Karran, Asher Mullard

Nat Rev Drug Discov· April 2015

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