Publications by authors named "Simon Osborne"

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Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs.
David A Baker, Alexios N Matralis, Simon A Osborne, Jonathan M Large, Maria Penzo

Front Microbiol· December 2020

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Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.
Jonathan M Large, Kristian Birchall, Nathalie S Bouloc, Andy T Merritt, Ela Smiljanic-Hurley, Simon A Osborne

Bioorg Med Chem Lett· October 2019

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Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Malaria Parasites.
Alexios N Matralis, Adnan Malik, Maria Penzo, Inmaculada Moreno, Maria J Almela, Simon A Osborne

J Med Chem· October 2019

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Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.
Jonathan M Large, Kristian Birchall, Nathalie S Bouloc, Andy T Merritt, Ela Smiljanic-Hurley, Simon A Osborne

Bioorg Med Chem Lett· February 2019

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Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).
Denise J Tsagris, Kristian Birchall, Nathalie Bouloc, Jonathan M Large, Andy Merritt, Simon A Osborne

Bioorg Med Chem Lett· October 2018

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Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.
Elena Redondo-Castro, Dorte Faust, Simon Fox, Alex G Baldwin, Simon Osborne

Sci Rep· April 2018

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A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
David A Baker, Lindsay B Stewart, Jonathan M Large, Paul W Bowyer, Keith H Ansell, Simon A Osborne

Nat Commun· September 2017

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Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.
Judith L Green, Robert W Moon, David Whalley, Paul W Bowyer, Claire Wallace, Simon A Osborne

Antimicrob Agents Chemother· December 2015

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Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.
Katy J Petherick, Owen J L Conway, Chido Mpamhanga, Simon A Osborne, Ahmad Kamal

J Biol Chem· November 2015

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Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.
Katy J Petherick, Owen J L Conway, Chido Mpamhanga, Simon A Osborne, Ahmad Kamal

J Biol Chem· May 2015

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Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1.
Keith H Ansell, Hayley M Jones, David Whalley, Alisdair Hearn, Debra L Taylor, Simon A Osborne

Antimicrob Agents Chemother· October 2014

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Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
Timothy M Chapman, Simon A Osborne, Claire Wallace, Kristian Birchall, Nathalie Bouloc

J Med Chem· April 2014

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Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues.
Jonathan M Large, Simon A Osborne, Ela Smiljanic-Hurley, Keith H Ansell, Hayley M Jones

Bioorg Med Chem Lett· November 2013

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Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
Timothy M Chapman, Simon A Osborne, Nathalie Bouloc, Jonathan M Large, Claire Wallace

Bioorg Med Chem Lett· May 2013

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Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis.
Timothy M Chapman, Nathalie Bouloc, Roger S Buxton, Jasveen Chugh, Kathryn E A Lougheed, Simon A Osborne

Bioorg Med Chem Lett· May 2012

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Design of waveguide-integrated semiconductor laser sources for optical frequency comb generation.
David Bitauld, Simon Osborne, Stephen O'Brien

Opt Lett· August 2011

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Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents.
Kathryn E A Lougheed, Simon A Osborne, Barbara Saxty, David Whalley, Tim Chapman

Tuberculosis (Edinb)· July 2011

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Timing characterization of 100 GHz passively mode-locked discrete mode laser diodes.
David Bitauld, Simon Osborne, Stephen O'Brien

Opt Express· July 2011

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Passive harmonic mode locking by mode selection in Fabry-Perot diode lasers with patterned effective index.
David Bitauld, Simon Osborne, Stephen O'Brien

Opt Lett· July 2010

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Synthesis and in vivo evaluation of 3-substituted gababutins.
David C Blakemore, Justin S Bryans, Pauline Carnell, Nicola E A Chessum, Mark J Field, Simon A Osborne

Bioorg Med Chem Lett· January 2010

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Synthesis and in vivo evaluation of 3,4-disubstituted gababutins.
David C Blakemore, Justin S Bryans, Pauline Carnell, Mark J Field, Natasha Kinsella, Simon A Osborne

Bioorg Med Chem Lett· January 2010

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Synthesis and in vivo evaluation of bicyclic gababutins.
David C Blakemore, Justin S Bryans, Pauline Carnell, Christopher L Carr, Nicola E A Chessum, Simon A Osborne

Bioorg Med Chem Lett· January 2010

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New anti-tuberculosis agents amongst known drugs.
Kathryn E A Lougheed, Debra L Taylor, Simon A Osborne, Justin S Bryans, Roger S Buxton

Tuberculosis (Edinb)· September 2009

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In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists.
Simon J Mantell, Karl R Gibson, Simon A Osborne, Graham N Maw, Huw Rees

Bioorg Med Chem Lett· April 2009

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Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes.
Sharon Yeoh, Rebecca A O'Donnell, Konstantinos Koussis, Anton R Dluzewski, Keith H Ansell, Simon A Osborne

Cell· December 2007

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