Publications by authors named "Eric Lechman"

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FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells.
Joana L Araújo, Elvin Wagenblast, Veronique Voisin, Jessica McLeod, Olga I Gan, Eric Lechman

Blood· May 2025

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KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition.
Liberalis Debraj Boila, Subhadeep Ghosh, Subham K Bandyopadhyay, Liqing Jin, Alex Murison, Eric R Lechman

Leukemia· April 2023

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PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal.
Ava Keyvani Chahi, Muluken S Belew, Joshua Xu, He Tian Tony Chen, Stefan Rentas, Eric Lechman

Blood· September 2022

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Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML.
Gabriela Krivdova, Veronique Voisin, Erwin M Schoof, Sajid A Marhon, Alex Murison, Eric R Lechman

Cell Rep· March 2022

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Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis.
Amit Subedi, Qiang Liu, Dhanoop M Ayyathan, David Sharon, Severine Cathelin, Eric R Lechman

Cell Stem Cell· October 2021

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Mapping the cellular origin and early evolution of leukemia in Down syndrome.
Elvin Wagenblast, Joana Araújo, Olga I Gan, Sarah K Cutting, Alex Murison, Eric R Lechman

Science· July 2021

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Quantitative single-cell proteomics as a tool to characterize cellular hierarchies.
Erwin M Schoof, Benjamin Furtwängler, Nil Üresin, Nicolas Rapin, Simonas Savickas, Eric Lechman

Nat Commun· June 2021

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Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells.
Elvin Wagenblast, Maria Azkanaz, Sabrina A Smith, Lorien Shakib, Jessica L McLeod, Eric R Lechman

Nat Commun· October 2019

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A novel method for detecting the cellular stemness state in normal and leukemic human hematopoietic cells can predict disease outcome and drug sensitivity.
Muhammad Yassin, Nasma Aqaqe, Abed Alkader Yassin, Peter van Galen, Eitan Kugler, Eric R Lechman

Leukemia· August 2019

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An Enhancer-Based Reporter Identifies Leukemia Cells with Elevated Leukemogenic Potential Driven by ERG-USP9X Feed-Forward Regulation.
Nasma Aqaqe, Muhammad Yassin, Abed Alkader Yassin, Nour Ershaid, Chen Katz-Even, Eric R Lechman

Cancer Res· August 2019

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A stemness screen reveals as a promoter of human leukemia stem cell latency.
Kerstin B Kaufmann, Laura Garcia-Prat, Qiang Liu, Stanley W K Ng, Shin-Ichiro Takayanagi, Eric R Lechman

Blood· May 2019

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Global proteomics dataset of miR-126 overexpression in acute myeloid leukemia.
Erwin M Schoof, Eric R Lechman, John E Dick

Data Brief· December 2016

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Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors.
Edyta E Wojtowicz, Eric R Lechman, Karin G Hermans, Erwin M Schoof, Erno Wienholds

Cell Stem Cell· September 2016

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miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia.
Silvia Nucera, Alice Giustacchini, Francesco Boccalatte, Andrea Calabria, Cristiana Fanciullo, Eric R Lechman

Cancer Cell· June 2016

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miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.
Eric R Lechman, Bernhard Gentner, Stanley W K Ng, Erwin M Schoof, Peter van Galen

Cancer Cell· April 2016

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miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.
Eric R Lechman, Bernhard Gentner, Stanley W K Ng, Erwin M Schoof, Peter van Galen

Cancer Cell· February 2016

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Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion.
Peter van Galen, Antonija Kreso, Erno Wienholds, Elisa Laurenti, Kolja Eppert, Eric R Lechman

Cell Stem Cell· January 2014

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Attenuation of miR-126 activity expands HSC in vivo without exhaustion.
Eric R Lechman, Bernhard Gentner, Peter van Galen, Alice Giustacchini, Massimo Saini

Cell Stem Cell· December 2012

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Stem cell gene expression programs influence clinical outcome in human leukemia.
Kolja Eppert, Katsuto Takenaka, Eric R Lechman, Levi Waldron, Björn Nilsson

Nat Med· August 2011

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Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy.
Bernhard Gentner, Ilaria Visigalli, Hidefumi Hiramatsu, Eric Lechman, Silvia Ungari

Sci Transl Med· November 2010

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A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.
Michael Milyavsky, Olga I Gan, Magan Trottier, Martin Komosa, Ofer Tabach, Eric Lechman

Cell Stem Cell· August 2010

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Comparison of human cord blood engraftment between immunocompromised mouse strains.
Sean P McDermott, Kolja Eppert, Eric R Lechman, Monica Doedens, John E Dick

Blood· July 2010

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Element-tagged immunoassay with ICP-MS detection: evaluation and comparison to conventional immunoassays.
Eva Razumienko, Olga Ornatsky, Robert Kinach, Michael Milyavsky, Eric Lechman

J Immunol Methods· July 2008

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Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis.
Annahita Keravala, Eric R Lechman, Joan Nash, Zhibao Mi, Paul D Robbins

Arthritis Res Ther· February 2007

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Hyperactive Himar1 transposase mediates transposition in cell culture and enhances gene expression in vivo.
Annahita Keravala, Dexi Liu, Eric R Lechman, Darren Wolfe, Joan A Nash

Hum Gene Ther· October 2006

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