Publications by authors named "Eric Morinello"

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Development of Duration-Based Non-Mutagenic Thresholds of Toxicological Concern (TTCs) Relevant to Parenteral Extractables and Leachables (E&Ls).
Melisa J Masuda-Herrera, Joel P Bercu, Thomas H Broschard, Anders Burild, Catrin Hasselgren, Eric Morinello

PDA J Pharm Sci Technol· October 2022

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Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats.
Jinze Li, Eric Morinello, Thomas Larsen, Denzil Frost, Ivor Caro

Regul Toxicol Pharmacol· February 2018

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Point of departure (PoD) selection for the derivation of acceptable daily exposures (ADEs) for active pharmaceutical ingredients (APIs).
Joel P Bercu, Eric J Morinello, Claudia Sehner, Bryan K Shipp, Patricia A Weideman

Regul Toxicol Pharmacol· August 2016

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Using default methodologies to derive an acceptable daily exposure (ADE).
Ellen C Faria, Joel P Bercu, David G Dolan, Eric J Morinello, Alison M Pecquet

Regul Toxicol Pharmacol· August 2016

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Determination of GDC-0980 (apitolisib), a small molecule dual phosphatidylinositide 3-kinase/mammalian target of rapamycin inhibitor in dog plasma by LC-MS/MS to support a GLP toxicology study.
Xiao Ding, Laurent Salphati, Amy Kim, Eric Morinello, Lisa Wong

Biomed Chromatogr· August 2015

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Embryofetal development study of vismodegib, a hedgehog pathway inhibitor, in rats.
Eric Morinello, Michael Pignatello, Loris Villabruna, Petra Goelzer, Heinrich Bürgin

Birth Defects Res B Dev Reprod Toxicol· April 2014

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Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling.
Harvey Wong, Frank-Peter Theil, Yong Cui, James C Marsters, S Cyrus Khojasteh, Eric J Morinello

Drug Metab Dispos· July 2010

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The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene.
Richard Albertini, Harvey Clewell, Matthew W Himmelstein, Eric Morinello, Stephen Olin

Regul Toxicol Pharmacol· February 2003

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Differential induction of N(2),3-ethenoguanine in rat brain and liver after exposure to vinyl chloride.
Eric J Morinello, Hasan Koc, Asoka Ranasinghe, James A Swenberg

Cancer Res· September 2002

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Molecular dosimetry and repair of N(2),3-ethenoguanine in rats exposed to vinyl chloride.
Eric J Morinello, Amy-Joan L Ham, Asoka Ranasinghe, Jun Nakamura, Patricia B Upton

Cancer Res· September 2002

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Methods for measuring DNA adducts and abasic sites I: isolation, purification, and analysis of DNA adducts in intact DNA.
James A Swenberg, Amy-Joan L Ham, Kevin S McDorman, Eric J Morinello, Jun Nakamura

Curr Protoc Toxicol· August 2002

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Methods for measuring DNA adducts and abasic sites II: methods for measurement of DNA adducts.
James A Swenberg, Amy-Joan L Ham, Hasan Koc, David K La, Eric J Morinello

Curr Protoc Toxicol· August 2002

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