Publications by authors named "Eric Tien"

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Inhibition of immune response reduces pathology in dorsal root ganglia and peripheral nerves in cynomolgus macaques following AAV gene therapy.
Branka Grubor, Kate L Henry, Su Jing Chan, Mark Sheehan, Anumeha Shah, Eric Tien

Mol Ther Methods Clin Dev· December 2025

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Comprehensive extractables and leachables sensitization analysis and practical application of a risk-based approach to sensitization assessment for parenteral drug products.
Patricia Parris, Geraldine Whelan, Martyn L Chilton, Claire Beaumont, Anders Burild, Eric Tien

Regul Toxicol Pharmacol· March 2025

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Adeno-Associated Virus-Mediated Dorsal Root Ganglion Toxicity in the New Zealand White Rabbit.
Eric Tien, Branka Grubor, Melissa Kirkland, Su Jing Chan, Nick van der Munnik

Toxicol Pathol· January 2024

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Framework for sensitization assessment of extractables and leachables in pharmaceuticals.
Patricia Parris, Geraldine Whelan, Anders Burild, Jessica Whritenour, Uma Bruen, Eric Tien

Crit Rev Toxicol· February 2022

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Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
Brian T Hopkins, Eris Bame, Bekim Bajrami, Cheryl Black, Tonika Bohnert, Eric Tien

J Med Chem· January 2022

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Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.
Bin Ma, Tonika Bohnert, Kevin L Otipoby, Eric Tien, Million Arefayene

J Med Chem· November 2020

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Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394.
Paul J Dransfield, Vatee Pattaropong, Sujen Lai, Zice Fu, Todd J Kohn, Eric Tien

ACS Med Chem Lett· July 2016

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RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation.
Steven Haney, Juan Zhao, Shiwani Tiwari, Kurt Eng, Lin T Guey, Eric Tien

PLoS One· February 2014

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Assessment of hepatotoxicity potential of drug candidate molecules including kinase inhibitors by hepatocyte imaging assay technology and bile flux imaging assay technology.
Jinghai J Xu, Margaret C Dunn, Arthur R Smith, Eric S Tien

Methods Mol Biol· January 2012

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Examination of Ligand-Dependent Coactivator Recruitment by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha).
Eric S Tien, Daniel B Hannon, Jerry T Thompson, John P Vanden Heuvel

PPAR Res· July 2011

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The nuclear receptor constitutively active/androstane receptor regulates type 1 deiodinase and thyroid hormone activity in the regenerating mouse liver.
Eric S Tien, Kenji Matsui, Rick Moore, Masahiko Negishi

J Pharmacol Exp Ther· January 2007

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Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator.
Eric S Tien, John W Davis, John P Vanden Heuvel

J Biol Chem· June 2004

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Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity.
Wasana K Sumanasekera, Eric S Tien, John W Davis, Rex Turpey, Gary H Perdew

Biochemistry· September 2003

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Comprehensive gene expression analysis of peroxisome proliferator-treated immortalized hepatocytes: identification of peroxisome proliferator-activated receptor alpha-dependent growth regulatory genes.
Eric S Tien, Joshua P Gray, Jeffrey M Peters, John P Vanden Heuvel

Cancer Res· September 2003

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Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2.
Wasana K Sumanasekera, Eric S Tien, Rex Turpey, John P Vanden Heuvel, Gary H Perdew

J Biol Chem· February 2003

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