Publications by authors named "Kevin L Otipoby"

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Therapeutic IgG- and IgM-specific proteases disarm the acetylcholine receptor autoantibodies that drive myasthenia gravis pathology.
Alexandra C Bayer, Liliana M Sanmarco, Alex Pellerin, Gianvito Masi, Agustin Plasencia, Kevin L Otipoby

Proc Natl Acad Sci U S A· October 2025

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Safety, pharmacokinetics, and pharmacodynamics of MK-6194, an IL-2 mutein designed to selectively activate regulatory T cells: single ascending dose and multiple ascending dose trial data.
Johannes F Scheid, Kiki Cunningham-Bussel, Nancy Kim, Shiuli Agarwal, Garrett Nieddu, Kevin L Otipoby

Immunohorizons· March 2025

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Author Correction: Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.
Neal N Iwakoshi, Ann-Hwee Lee, Prasanth Vallabhajosyula, Kevin L Otipoby, Klaus Rajewsky

Nat Immunol· May 2024

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Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
Brian T Hopkins, Eris Bame, Bekim Bajrami, Cheryl Black, Tonika Bohnert, Kevin L Otipoby

J Med Chem· January 2022

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HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice.
Rajeev K Tyagi, Justin Jacobse, Jing Li, Margret M Allaman, Kevin L Otipoby

Front Immunol· September 2021

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Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.
Bin Ma, Tonika Bohnert, Kevin L Otipoby, Eric Tien, Million Arefayene

J Med Chem· November 2020

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Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.
Brian T Hopkins, Eris Bame, Noah Bell, Tonika Bohnert, Jon K Bowden-Verhoek, Kevin L Otipoby

Bioorg Med Chem· July 2019

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BCR-dependent lineage plasticity in mature B cells.
Robin Graf, Jane Seagal, Kevin L Otipoby, Kong-Peng Lam, Salah Ayoub

Science· February 2019

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CD62L is not a reliable biomarker for predicting PML risk in natalizumab-treated R-MS patients.
Linda A Lieberman, Wanyong Zeng, Carol Singh, Wenting Wang, Kevin L Otipoby

Neurology· January 2016

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The B-cell antigen receptor integrates adaptive and innate immune signals.
Kevin L Otipoby, Ari Waisman, Emmanuel Derudder, Lakshmi Srinivasan, Andrew Franklin

Proc Natl Acad Sci U S A· September 2015

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Anti-BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fc-independent mechanisms.
Alex Pellerin, Karel Otero, Julie M Czerkowicz, Hannah M Kerns, Renée I Shapiro, Kevin L Otipoby

EMBO Mol Med· April 2015

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The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling.
Pieta K Mattila, Christoph Feest, David Depoil, Bebhinn Treanor, Beatriz Montaner, Kevin L Otipoby

Immunity· March 2013

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Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation.
Heide Christine Patterson, Manfred Kraus, Donghai Wang, Aliakbar Shahsafaei, Joel M Henderson, Kevin L Otipoby

J Immunol· September 2011

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PI3 kinase signals BCR-dependent mature B cell survival.
Lakshmi Srinivasan, Yoshiteru Sasaki, Dinis Pedro Calado, Baochun Zhang, Ji Hye Paik, Kevin L Otipoby

Cell· October 2009

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BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Kevin L Otipoby, Yoshiteru Sasaki, Marc Schmidt-Supprian, Alina Patke, Ralph Gareus

Proc Natl Acad Sci U S A· August 2008

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Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells.
J Rodrigo Mora, Makoto Iwata, Bertus Eksteen, Si-Young Song, Tobias Junt, Kevin L Otipoby

Science· November 2006

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Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.
Lina E Tze, Brian R Schram, Kong-Peng Lam, Kristin A Hogquist, Keli L Hippen, Kevin L Otipoby

PLoS Biol· March 2005

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B cell receptor signal strength determines B cell fate.
Stefano Casola, Kevin L Otipoby, Marat Alimzhanov, Sibille Humme, Nathalie Uyttersprot

Nat Immunol· March 2004

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Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71.
Philipp Oberdoerffer, Kevin L Otipoby, Mitsuo Maruyama, Klaus Rajewsky

Nucleic Acids Res· November 2003

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Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.
Neal N Iwakoshi, Ann-Hwee Lee, Prasanth Vallabhajosyula, Kevin L Otipoby, Klaus Rajewsky

Nat Immunol· April 2003

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