Publications by authors named "Eric W Hewitt"

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Single molecule delivery into living cells.
Chalmers C Chau, Christopher M Maffeo, Aleksei Aksimentiev, Sheena E Radford, Eric W Hewitt

Nat Commun· May 2024

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Modulation of β-Amyloid Fibril Formation in Alzheimer's Disease by Microglia and Infection.
Madeleine R Brown, Sheena E Radford, Eric W Hewitt

Front Mol Neurosci· November 2020

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Macromolecular Crowding Enhances the Detection of DNA and Proteins by a Solid-State Nanopore.
Chalmers C Chau, Sheena E Radford, Eric W Hewitt, Paolo Actis

Nano Lett· July 2020

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Structural mapping of oligomeric intermediates in an amyloid assembly pathway.
Theodoros K Karamanos, Matthew P Jackson, Antonio N Calabrese, Sophia C Goodchild, Emma E Cawood, Eric W Hewitt

Elife· September 2019

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A new era for understanding amyloid structures and disease.
Matthew G Iadanza, Matthew P Jackson, Eric W Hewitt, Neil A Ranson, Sheena E Radford

Nat Rev Mol Cell Biol· December 2018

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Why are Functional Amyloids Non-Toxic in Humans?
Matthew P Jackson, Eric W Hewitt

Biomolecules· September 2017

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Cellular proteostasis: degradation of misfolded proteins by lysosomes.
Matthew P Jackson, Eric W Hewitt

Essays Biochem· October 2016

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Comparison of the aggregation of homologous β2-microglobulin variants reveals protein solubility as a key determinant of amyloid formation.
Clare L Pashley, Eric W Hewitt, Sheena E Radford

J Mol Biol· February 2016

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Amyloid Fibres: Inert End-Stage Aggregates or Key Players in Disease?
Kevin W Tipping, Patricija van Oosten-Hawle, Eric W Hewitt, Sheena E Radford

Trends Biochem Sci· December 2015

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β2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH.
Sophia C Goodchild, Tania Sheynis, Rebecca Thompson, Kevin W Tipping, Wei-Feng Xue, Eric W Hewitt

PLoS One· November 2015

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Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells.
Andrew L Hellewell, Ombretta Foresti, Nicola Gover, Morwenna Y Porter, Eric W Hewitt

PLoS One· June 2015

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pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers.
Kevin W Tipping, Theodoros K Karamanos, Toral Jakhria, Matthew G Iadanza, Sophia C Goodchild, Eric W Hewitt

Proc Natl Acad Sci U S A· May 2015

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β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes.
Toral Jakhria, Andrew L Hellewell, Morwenna Y Porter, Matthew P Jackson, Kevin W Tipping, Eric W Hewitt

J Biol Chem· December 2014

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Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils.
Tania Sheynis, Anat Friediger, Wei-Feng Xue, Andrew L Hellewell, Kevin W Tipping, Eric W Hewitt

Biophys J· August 2013

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Direct three-dimensional visualization of membrane disruption by amyloid fibrils.
Lilia Milanesi, Tania Sheynis, Wei-Feng Xue, Elena V Orlova, Andrew L Hellewell, Eric W Hewitt

Proc Natl Acad Sci U S A· December 2012

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Characterization of the response of primary cells relevant to dialysis-related amyloidosis to β2-microglobulin monomer and fibrils.
Morwenna Y Porter, Katy E Routledge, Sheena E Radford, Eric W Hewitt

PLoS One· April 2012

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Ligand binding to distinct states diverts aggregation of an amyloid-forming protein.
Lucy A Woods, Geoffrey W Platt, Andrew L Hellewell, Eric W Hewitt, Steve W Homans

Nat Chem Biol· August 2011

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Fibril fragmentation in amyloid assembly and cytotoxicity: when size matters.
Wei-Feng Xue, Andrew L Hellewell, Eric W Hewitt, Sheena E Radford

Prion· July 2010

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Fibril fragmentation enhances amyloid cytotoxicity.
Wei-Feng Xue, Andrew L Hellewell, Walraj S Gosal, Steve W Homans, Eric W Hewitt

J Biol Chem· December 2009

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Dependence of the localization and function of the human cytomegalovirus protein US6 on the transporter associated with antigen processing.
Gillian E Dugan, Eric W Hewitt

J Gen Virol· September 2009

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Natural killer cell cytotoxicity: how do they pull the trigger?
Nicola J Topham, Eric W Hewitt

Immunology· September 2009

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Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway.
Faye Gould, Sally M Harrison, Eric W Hewitt, Adrian Whitehouse

J Virol· July 2009

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Structural and Functional Dissection of the Human Cytomegalovirus Immune Evasion Protein US6.
Gillian E Dugan, Eric W Hewitt

J Virol· April 2008

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Investigation into the role of macrophages in the formation and degradation of beta2-microglobulin amyloid fibrils.
Isobel J Morten, Walraj S Gosal, Sheena E Radford, Eric W Hewitt

J Biol Chem· October 2007

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Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome.
Tammy M Casey, Josephine L Meade, Eric W Hewitt

Mol Cell Proteomics· May 2007

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